Animal models for COVID-19.


Journal

Nature
ISSN: 1476-4687
Titre abrégé: Nature
Pays: England
ID NLM: 0410462

Informations de publication

Date de publication:
10 2020
Historique:
received: 22 06 2020
accepted: 15 09 2020
pubmed: 24 9 2020
medline: 30 10 2020
entrez: 23 9 2020
Statut: ppublish

Résumé

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the aetiological agent of coronavirus disease 2019 (COVID-19), an emerging respiratory infection caused by the introduction of a novel coronavirus into humans late in 2019 (first detected in Hubei province, China). As of 18 September 2020, SARS-CoV-2 has spread to 215 countries, has infected more than 30 million people and has caused more than 950,000 deaths. As humans do not have pre-existing immunity to SARS-CoV-2, there is an urgent need to develop therapeutic agents and vaccines to mitigate the current pandemic and to prevent the re-emergence of COVID-19. In February 2020, the World Health Organization (WHO) assembled an international panel to develop animal models for COVID-19 to accelerate the testing of vaccines and therapeutic agents. Here we summarize the findings to date and provides relevant information for preclinical testing of vaccine candidates and therapeutic agents for COVID-19.

Identifiants

pubmed: 32967005
doi: 10.1038/s41586-020-2787-6
pii: 10.1038/s41586-020-2787-6
pmc: PMC8136862
mid: NIHMS1700241
doi:

Substances chimiques

COVID-19 Vaccines 0
Viral Vaccines 0

Types de publication

Journal Article Review

Langues

eng

Sous-ensembles de citation

IM

Pagination

509-515

Subventions

Organisme : NIAID NIH HHS
ID : R01 AI157155
Pays : United States
Organisme : NIH HHS
ID : P51 OD011104
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI148166
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI129269
Pays : United States
Organisme : NIAID NIH HHS
ID : P01 AI060699
Pays : United States
Organisme : World Health Organization
ID : 001
Pays : International

Commentaires et corrections

Type : CommentIn

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Auteurs

César Muñoz-Fontela (C)

Bernhard Nocht Institute for Tropical Medicine, Hamburg, Germany.
German Center for Infection Research (DZIF), Partner site Hamburg-Lübeck-Borstel-Riems, Hamburg, Germany.

William E Dowling (WE)

Centre for Epidemic Preparedness Innovations (CEPI), Washington, DC, USA.

Simon G P Funnell (SGP)

National Infection Service, Public Health England, Salisbury, UK.

Pierre-S Gsell (PS)

World Health Organization, Geneva, Switzerland.

A Ximena Riveros-Balta (AX)

World Health Organization, Geneva, Switzerland.

Randy A Albrecht (RA)

Department of Microbiology, Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.

Hanne Andersen (H)

Bioqual Inc, Rockville, MD, USA.

Ralph S Baric (RS)

Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.

Miles W Carroll (MW)

National Infection Service, Public Health England, Salisbury, UK.

Marco Cavaleri (M)

European Medicines Agency, Amsterdam, The Netherlands.

Chuan Qin (C)

Institute of Laboratory Animal Sciences, Chinese Academy of Medical Sciences and Peking Union Medical College, Peking, China.

Ian Crozier (I)

Clinical Monitoring Research Program Directorate, Frederick National Laboratory for Cancer Research, Frederick, MD, USA.

Kai Dallmeier (K)

KU Leuven Department of Microbiology, Immunology and Transplantation, Rega Institute, Laboratory of Virology and Chemotherapy, Leuven, Belgium.

Leon de Waal (L)

Viroclinics Xplore, Schaijk, The Netherlands.

Emmie de Wit (E)

Laboratory of Virology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT, USA.

Leen Delang (L)

KU Leuven Department of Microbiology, Immunology and Transplantation, Rega Institute, Laboratory of Virology and Chemotherapy, Leuven, Belgium.

Erik Dohm (E)

Animal Resources Program, University of Alabama at Birmingham, Birmingham, AL, USA.

W Paul Duprex (WP)

Department of Microbiology and Molecular Genetics, Center for Vaccine Research, University of Pittsburgh, Pittsburgh, PA, USA.

Darryl Falzarano (D)

VIDO-Intervac, University of Saskatchewan, Saskatoon, Saskatchewan, Canada.

Courtney L Finch (CL)

Integrated Research Facility at Fort Detrick, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Frederick, MD, USA.

Matthew B Frieman (MB)

Department of Microbiology and Immunology, University of Maryland School of Medicine, Baltimore, MD, USA.

Barney S Graham (BS)

Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.

Lisa E Gralinski (LE)

Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.

Kate Guilfoyle (K)

Viroclinics Xplore, Schaijk, The Netherlands.

Bart L Haagmans (BL)

Department of Viroscience, Erasmus University Medical Center, Rotterdam, The Netherlands.

Geraldine A Hamilton (GA)

Emulate Inc, Boston, MA, USA.

Amy L Hartman (AL)

Department of Microbiology and Molecular Genetics, Center for Vaccine Research, University of Pittsburgh, Pittsburgh, PA, USA.

Sander Herfst (S)

Department of Viroscience, Erasmus University Medical Center, Rotterdam, The Netherlands.

Suzanne J F Kaptein (SJF)

KU Leuven Department of Microbiology, Immunology and Transplantation, Rega Institute, Laboratory of Virology and Chemotherapy, Leuven, Belgium.

William B Klimstra (WB)

Department of Immunology, Center for Vaccine Research, University of Pittsburgh, Pittsburgh, PA, USA.

Ivana Knezevic (I)

World Health Organization, Geneva, Switzerland.

Philip R Krause (PR)

Center for Biologics Evaluation and Research, FDA, Silver Spring, MD, USA.

Jens H Kuhn (JH)

Integrated Research Facility at Fort Detrick, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Frederick, MD, USA.

Roger Le Grand (R)

Center for Immunology of Viral, Auto-immune, Hematological and Bacterial diseases (IMVA-HB/IDMIT), Inserm, CEA, Université Paris-Saclay, Paris, France.

Mark G Lewis (MG)

Bioqual Inc, Rockville, MD, USA.

Wen-Chun Liu (WC)

Department of Microbiology, Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.

Pauline Maisonnasse (P)

Center for Immunology of Viral, Auto-immune, Hematological and Bacterial diseases (IMVA-HB/IDMIT), Inserm, CEA, Université Paris-Saclay, Paris, France.

Anita K McElroy (AK)

Division of Pediatric Infectious Diseases, Center for Vaccine Research, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.

Vincent Munster (V)

Laboratory of Virology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT, USA.

Nadia Oreshkova (N)

Wageningen Bioveterinary Research (WBVR), Wageningen University and Research, Lelystad, The Netherlands.

Angela L Rasmussen (AL)

Center for Infection and Immunity, Columbia Mailman |School of Public Health, New York, NY, USA.

Joana Rocha-Pereira (J)

KU Leuven Department of Microbiology, Immunology and Transplantation, Rega Institute, Laboratory of Virology and Chemotherapy, Leuven, Belgium.

Barry Rockx (B)

Department of Viroscience, Erasmus University Medical Center, Rotterdam, The Netherlands.

Estefanía Rodríguez (E)

Bernhard Nocht Institute for Tropical Medicine, Hamburg, Germany.
German Center for Infection Research (DZIF), Partner site Hamburg-Lübeck-Borstel-Riems, Hamburg, Germany.

Thomas F Rogers (TF)

Division of Infectious Diseases, University of California San Diego, San Diego, CA, USA.

Francisco J Salguero (FJ)

National Infection Service, Public Health England, Salisbury, UK.

Michael Schotsaert (M)

Department of Microbiology, Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.

Koert J Stittelaar (KJ)

Viroclinics Xplore, Schaijk, The Netherlands.

Hendrik Jan Thibaut (HJ)

KU Leuven Department of Microbiology, Immunology and Transplantation, Rega Institute, Laboratory of Virology and Chemotherapy, Leuven, Belgium.

Chien-Te Tseng (CT)

Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, TX, USA.

Júlia Vergara-Alert (J)

Centre de Recerca en Sanitat Animal (CReSA, IRTA-UAB), Campus Universitat Autònoma de Barcelona, Bellaterra, Spain.

Martin Beer (M)

Institute of Diagnostic Virology, Friedrich-Loeffler-Institut, Greifswald-Insel Riems, Germany.

Trevor Brasel (T)

Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, TX, USA.

Jasper F W Chan (JFW)

Carol Yu Centre for Infection, Department of Microbiology, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong, China.

Adolfo García-Sastre (A)

Department of Microbiology, Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.

Johan Neyts (J)

KU Leuven Department of Microbiology, Immunology and Transplantation, Rega Institute, Laboratory of Virology and Chemotherapy, Leuven, Belgium.

Stanley Perlman (S)

Department of Microbiology and Immunology, University of Iowa, Iowa City, IA, USA.

Douglas S Reed (DS)

Department of Immunology, Center for Vaccine Research, University of Pittsburgh, Pittsburgh, PA, USA.

Juergen A Richt (JA)

College of Veterinary Medicine, Kansas State University, Manhattan, KS, USA.

Chad J Roy (CJ)

Tulane National Primate Research Center, Covington, LA, USA.

Joaquim Segalés (J)

Centre de Recerca en Sanitat Animal (CReSA, IRTA-UAB), Campus Universitat Autònoma de Barcelona, Bellaterra, Spain.
Departament de Sanitat i Anatomia Animals, Facultat de Veterinària, UAB, Bellaterra, Spain.

Seshadri S Vasan (SS)

Australian Centre for Disease Preparedness, CSIRO, Geelong, Victoria, Australia.
Department of Health Sciences, University of York, York, UK.

Ana María Henao-Restrepo (AM)

World Health Organization, Geneva, Switzerland. henaorestrepoa@who.int.

Dan H Barouch (DH)

Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA. dbarouch@bidmc.harvard.edu.

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