Neural correlates of polygenic risk score for autism spectrum disorders in general population.

autism spectrum disorders cortical thickness genetics polygenic risk score structural connectivity

Journal

Brain communications
ISSN: 2632-1297
Titre abrégé: Brain Commun
Pays: England
ID NLM: 101755125

Informations de publication

Date de publication:
2020
Historique:
received: 24 07 2019
revised: 06 05 2020
accepted: 04 06 2020
entrez: 21 9 2020
pubmed: 22 9 2020
medline: 22 9 2020
Statut: epublish

Résumé

Autism spectrum disorder is a highly prevalent and highly heritable neurodevelopmental condition, but studies have mostly taken traditional categorical diagnosis approach (yes/no for autism spectrum disorder). In contrast, an emerging notion suggests a continuum model of autism spectrum disorder with a normal distribution of autistic tendencies in the general population, where a full diagnosis is at the severe tail of the distribution. We set out to investigate such a viewpoint by investigating the interaction of polygenic risk scores for autism spectrum disorder and Age

Identifiants

pubmed: 32954337
doi: 10.1093/braincomms/fcaa092
pii: fcaa092
pmc: PMC7475696
doi:

Types de publication

Journal Article

Langues

eng

Pagination

fcaa092

Informations de copyright

© The Author(s) (2020). Published by Oxford University Press on behalf of the Guarantors of Brain.

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Auteurs

Budhachandra Khundrakpam (B)

McGill Centre for Integrative Neuroscience, Montreal Neurological Institute, McGill University, Montreal, QC H3A 2B4, Canada.
Ludmer Centre for Neuroinformatics and Mental Health, McGill University, Montreal, QC H3A 2B4, Canada.

Uku Vainik (U)

Montreal Neurological Institute, McGill University, Montreal, QC H3A 2B4, Canada.
Faculty of Social Sciences, Institute of Psychology, University of Tartu, Tartu 50090, Estonia.

Jinnan Gong (J)

Montreal Neurological Institute, McGill University, Montreal, QC H3A 2B4, Canada.
Clinical Hospital of Chengdu Brain Science Institute, MOE Ley Lab for Neuroinformation, Center for Information in Medicine, University of Electronic Science and Technology of China, Chengdu, Sichuan 611731, China.

Noor Al-Sharif (N)

McGill Centre for Integrative Neuroscience, Montreal Neurological Institute, McGill University, Montreal, QC H3A 2B4, Canada.

Neha Bhutani (N)

McGill Centre for Integrative Neuroscience, Montreal Neurological Institute, McGill University, Montreal, QC H3A 2B4, Canada.

Gregory Kiar (G)

McGill Centre for Integrative Neuroscience, Montreal Neurological Institute, McGill University, Montreal, QC H3A 2B4, Canada.

Yashar Zeighami (Y)

McGill Centre for Integrative Neuroscience, Montreal Neurological Institute, McGill University, Montreal, QC H3A 2B4, Canada.

Matthias Kirschner (M)

Montreal Neurological Institute, McGill University, Montreal, QC H3A 2B4, Canada.
Department of Psychiatry, Psychotherapy and Psychosomatics, Psychiatric Hospital, University of Zurich, Zurich 8032, Switzerland.

Cheng Luo (C)

Clinical Hospital of Chengdu Brain Science Institute, MOE Ley Lab for Neuroinformation, Center for Information in Medicine, University of Electronic Science and Technology of China, Chengdu, Sichuan 611731, China.

Alain Dagher (A)

Montreal Neurological Institute, McGill University, Montreal, QC H3A 2B4, Canada.

Alan Evans (A)

McGill Centre for Integrative Neuroscience, Montreal Neurological Institute, McGill University, Montreal, QC H3A 2B4, Canada.
Ludmer Centre for Neuroinformatics and Mental Health, McGill University, Montreal, QC H3A 2B4, Canada.

Classifications MeSH