Improved antimicrobial properties of methylene blue attached to silver nanoparticles.
Bacteria deactivation
Methylene blue
Photodynamic therapy
Silver nanoparticles
Journal
Photodiagnosis and photodynamic therapy
ISSN: 1873-1597
Titre abrégé: Photodiagnosis Photodyn Ther
Pays: Netherlands
ID NLM: 101226123
Informations de publication
Date de publication:
Dec 2020
Dec 2020
Historique:
received:
01
07
2020
revised:
20
08
2020
accepted:
11
09
2020
pubmed:
19
9
2020
medline:
15
5
2021
entrez:
18
9
2020
Statut:
ppublish
Résumé
Photosensitizing agents are the cornerstone of Photodynamic Therapy (PDT). They play an essential role in deactivation process of multidrug resistant pathogens and tumor treatments. In this work, we studied a photosensitizing agent made from mixture of Silver Nanoparticles (Ag NPs) and Methylene Blue (MB) which possess improved important characteristics like high photostability and high singlet oxygen yield. Ag NPs were synthesized by pulsed laser ablation technique in different aqueous solutions like polyvinylpyrrolidone (PVP), citrate and Deionized (DI) water. The synthesized AgNPs were characterized in depth using with transmission electron microscopy (TEM), UV-vis (UV-vis), and photoluminescence (PL) spectra. These Ag NPs were combined with MB and used to eradicate the Gram-negative bacteria, Escherichia coli (E. coli), and Gram-positive bacteria, Staphylococcus aureus (S. aureus). MB and Ag NPs mixture was found to possess higher antimicrobial activity and thus were more effective in killing both Gram -positive and Gram-negative bacteria in comparison to individual exposure of MB and Ag NPs. Additionally, the antimicrobial effects varied with respect to the size of nanoparticles as well as the medium used for their synthesis. The data from this study supports the potential use of the proposed method in PDT where standard photosensitizers have limitations.
Identifiants
pubmed: 32947029
pii: S1572-1000(20)30366-5
doi: 10.1016/j.pdpdt.2020.102012
pmc: PMC8579323
mid: NIHMS1637887
pii:
doi:
Substances chimiques
Anti-Bacterial Agents
0
Anti-Infective Agents
0
Photosensitizing Agents
0
Silver
3M4G523W1G
Methylene Blue
T42P99266K
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
102012Subventions
Organisme : NIGMS NIH HHS
ID : P20 GM103436
Pays : United States
Informations de copyright
Copyright © 2020 Elsevier B.V. All rights reserved.
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