An overview of tecovirimat for smallpox treatment and expanded anti-orthopoxvirus applications.
Animal Rule
ST-246
Smallpox
biodefense
health security
monkeypox
tecovirimat
vaccinia
variola
Journal
Expert review of anti-infective therapy
ISSN: 1744-8336
Titre abrégé: Expert Rev Anti Infect Ther
Pays: England
ID NLM: 101181284
Informations de publication
Date de publication:
03 2021
03 2021
Historique:
pubmed:
4
9
2020
medline:
28
9
2021
entrez:
4
9
2020
Statut:
ppublish
Résumé
Tecovirimat (TPOXX®; ST-246) was approved for the treatment of symptomatic smallpox by the USFDA in July of 2018 and has been stockpiled by the US government for use in a smallpox outbreak. While there has not been a reported case of smallpox since 1978 it is still considered a serious bioterrorism threat. A brief history of smallpox from its proposed origins as a human disease through its eradication in the late 20th century is presented. The current smallpox threat and the current public health response plans are described. The discovery, and development of tecovirimat through NDA submission and subsequent approval for treatment of smallpox are discussed. Google Scholar and PubMed were searched over all available dates for relevant publications. Approval of tecovirimat to treat smallpox represents an important milestone in biosecurity preparedness. Incorporating tecovirimat into the CDC smallpox response plan, development of pediatric liquid and intravenous formulations, and approval for post-exposure prophylaxis would provide additional health security benefit.Tecovirimat shows broad efficacy against orthopoxviruses in vitro and in vivo and could be developed for use against emerging orthopoxvirus diseases such as monkeypox, vaccination-associated adverse events, and side effects of vaccinia oncolytic virus therapy.
Identifiants
pubmed: 32882158
doi: 10.1080/14787210.2020.1819791
pmc: PMC9491074
doi:
Substances chimiques
Antiviral Agents
0
Benzamides
0
Isoindoles
0
tecovirimat
F925RR824R
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
331-344Références
Curr Opin Infect Dis. 2008 Apr;21(2):153-6
pubmed: 18317038
Clin Infect Dis. 2008 May 15;46(10):1555-61
pubmed: 18419490
Curr Opin Infect Dis. 2004 Apr;17(2):81-9
pubmed: 15021045
PLoS One. 2018 Jan 19;13(1):e0188453
pubmed: 29351298
Vaccine. 2020 Jan 16;38(3):644-654
pubmed: 31677948
Emerg Infect Dis. 2018 Apr;24(4):646-653
pubmed: 29553311
Proc Natl Acad Sci U S A. 2010 Jan 12;107(2):838-43
pubmed: 20080762
Clin Infect Dis. 2008 Mar 15;46 Suppl 3:S157-67
pubmed: 18284355
Indian J Virol. 2012 Jun;23(1):1-11
pubmed: 23729995
Lancet Infect Dis. 2019 Nov;19(11):1166
pubmed: 31657773
Antiviral Res. 2012 Apr;94(1):44-53
pubmed: 22381921
Antimicrob Agents Chemother. 2009 Jun;53(6):2620-5
pubmed: 19349521
MMWR Morb Mortal Wkly Rep. 2009 May 22;58(19):532-6
pubmed: 19478722
MMWR Recomm Rep. 2001 Jun 22;50(RR-10):1-25; quiz CE1-7
pubmed: 15580803
Antimicrob Agents Chemother. 2012 Sep;56(9):4900-5
pubmed: 22777041
Euro Surveill. 2018 Sep;23(38):
pubmed: 30255836
JAMA. 1978 Oct 27;240(18):1991-2
pubmed: 691227
N Engl J Med. 2018 Jul 5;379(1):44-53
pubmed: 29972742
Zoonoses Public Health. 2010 Dec;57(7-8):e149-55
pubmed: 20042058
Antimicrob Agents Chemother. 2013 Mar;57(3):1136-43
pubmed: 23254433
J Immunother Cancer. 2019 Jan 9;7(1):6
pubmed: 30626434
J Virol. 2012 Dec;86(24):13501-7
pubmed: 23035222
Expert Rev Anti Infect Ther. 2019 Feb;17(2):129-139
pubmed: 30625020
N Engl J Med. 1980 Nov 27;303(22):1263-73
pubmed: 6252467
Arch Dermatol. 2010 Jun;146(6):656-61
pubmed: 20566929
Science. 2014 Jul 18;345(6194):247-8
pubmed: 25035464
Front Cell Infect Microbiol. 2018 Oct 05;8:356
pubmed: 30345258
Antimicrob Agents Chemother. 2009 May;53(5):1817-22
pubmed: 19223621
Antimicrob Agents Chemother. 2007 Feb;51(2):689-95
pubmed: 17116683
J Virol. 1991 Nov;65(11):5910-20
pubmed: 1920620
Antimicrob Agents Chemother. 2009 Mar;53(3):1007-12
pubmed: 19075062
Microbiol Rev. 1983 Dec;47(4):455-509
pubmed: 6319980
Expert Opin Biol Ther. 2020 Sep;20(9):1083-1097
pubmed: 32297534
Antimicrob Agents Chemother. 2012 Jul;56(7):3582-6
pubmed: 22526314
Antimicrob Agents Chemother. 2015 Jul;59(7):4296-300
pubmed: 25896687
Viruses. 2010 Nov;2(11):2409-2435
pubmed: 21994624
MMWR Recomm Rep. 2003 Apr 4;52(RR-7):1-16
pubmed: 12710832
J Med Chem. 2007 Apr 5;50(7):1442-4
pubmed: 17335190
Future Virol. 2011 May;6(5):653-671
pubmed: 21837250
Antivir Ther. 2007;12(8):1205-16
pubmed: 18240860
PLoS Negl Trop Dis. 2019 Oct 16;13(10):e0007791
pubmed: 31618206
Vaccine. 2013 Oct 25;31(45):5192-201
pubmed: 23994378
Antimicrob Agents Chemother. 2009 Dec;53(12):4999-5009
pubmed: 19752270
PLoS Pathog. 2013;9(12):e1003756
pubmed: 24339772
J Infect Dev Ctries. 2008 Jun 01;2(3):156-73
pubmed: 19738346
Expert Opin Biol Ther. 2019 Jun;19(6):561-573
pubmed: 30919708
J Virol. 2005 Oct;79(20):13139-49
pubmed: 16189015
Biosecur Bioterror. 2013 Mar;11(1):59-72
pubmed: 23530860
Adv Prev Med. 2012;2012:507571
pubmed: 21991452
Antimicrob Agents Chemother. 2010 Jun;54(6):2560-6
pubmed: 20385870
MMWR Morb Mortal Wkly Rep. 2016 Mar 18;65(10):257-62
pubmed: 26985679
Emerg Infect Dis. 2019 May;25(5):980-983
pubmed: 30848724
Int J Infect Dis. 2019 Jan;78:78-84
pubmed: 30453097
Proc Natl Acad Sci U S A. 2004 Oct 19;101(42):15196-200
pubmed: 15477589
Adv Virol. 2012;2012:524743
pubmed: 22899927
Environ Health Prev Med. 2011 Sep;16(5):281-9
pubmed: 21431786
Vopr Virusol. 2013 Jul-Aug;58(4):39-43
pubmed: 24354064
MMWR Morb Mortal Wkly Rep. 2009 Nov 6;58(43):1204-7
pubmed: 19893480
Vet Pathol. 2010 Sep;47(5):774-8
pubmed: 20551476
Fed Regist. 2002 May 31;67(105):37988-98
pubmed: 12049094
Vet Pathol. 2010 Sep;47(5):852-70
pubmed: 20682806
EMBO J. 1997 Aug 1;16(15):4519-30
pubmed: 9303296
Vaccines (Basel). 2018 Jan 29;6(1):
pubmed: 29382130
J Infect Dis. 2018 Sep 22;218(9):1490-1499
pubmed: 29982575
JAMA. 1999 Jun 9;281(22):2127-37
pubmed: 10367824
MMWR Morb Mortal Wkly Rep. 2018 Mar 16;67(10):306-310
pubmed: 29543790
J Gen Virol. 1980 Sep;50(1):89-100
pubmed: 7441216
J Antimicrob Chemother. 2015 May;70(5):1367-80
pubmed: 25630650
Clin Infect Dis. 2019 Nov 27;69(12):2205-2207
pubmed: 30959520
J Virol. 2011 Sep;85(17):9176-87
pubmed: 21697474
J Infect Dis. 2012 Nov;206(9):1372-85
pubmed: 22904336
Arch Pediatr Adolesc Med. 2005 Nov;159(11):1022-5
pubmed: 16275790
MMWR Morb Mortal Wkly Rep. 2019 Oct 25;68(42):943-946
pubmed: 31647789
Antimicrob Agents Chemother. 2008 May;52(5):1721-7
pubmed: 18316519
Public Health Rep. 1980 Sep-Oct;95(5):422-6
pubmed: 7422808
Am J Trop Med Hyg. 2007 Apr;76(4):768-73
pubmed: 17426185
J Virol. 1999 Feb;73(2):1108-17
pubmed: 9882312
J Gen Virol. 2002 Dec;83(Pt 12):2915-2931
pubmed: 12466468
Vaccine. 2014 Aug 20;32(37):4758-65
pubmed: 24951868
Antiviral Res. 2019 Aug;168:168-174
pubmed: 31181284
Ann Intern Med. 1997 Oct 15;127(8 Pt 1):635-42
pubmed: 9341063
Antimicrob Agents Chemother. 2013 Dec;57(12):6246-53
pubmed: 24100494
Antiviral Res. 2012 Jan;93(1):160-6
pubmed: 22138484
J Am Osteopath Assoc. 2005 Sep;105(9):417-24
pubmed: 16239492
Clin Microbiol Infect. 2014 Mar;20(3):210-8
pubmed: 24438205
J Infect Dis. 2003 Oct 1;188(7):973-6
pubmed: 14513416
Viruses. 2018 Jan 18;10(1):
pubmed: 29346277
Immunotherapy. 2015;7(12):1249-58
pubmed: 26595180
Bull World Health Organ. 1980;58(2):279-83
pubmed: 6967365
MMWR Recomm Rep. 2015 Feb 20;64(RR-02):1-26
pubmed: 25695372