Evaluation of diuretic efficacy and antiurolithiatic potential of ethanolic leaf extract of
Animals
Annona
/ chemistry
Disease Models, Animal
Diuresis
/ drug effects
Diuretics
/ isolation & purification
Ethylene Glycol
Female
Kidney
/ drug effects
Male
Plant Extracts
/ isolation & purification
Plant Leaves
/ chemistry
Rats, Wistar
Urodynamics
/ drug effects
Urolithiasis
/ chemically induced
Antiurolithiatic
diuretic
ethylene glycol
triterpenes
Journal
Indian journal of pharmacology
ISSN: 1998-3751
Titre abrégé: Indian J Pharmacol
Pays: India
ID NLM: 7902477
Informations de publication
Date de publication:
Historique:
received:
15
02
2018
revised:
08
08
2019
accepted:
13
07
2020
entrez:
3
9
2020
pubmed:
3
9
2020
medline:
14
7
2021
Statut:
ppublish
Résumé
The study is to investigate the diuretic and antiurolithiatic activities of ethanolic leaf extract of For both studies, Wistar albino rats and two doses of extract (250 and 500 mg/kg) were used. Diuretic activity was evaluated by Lipschitz model. Urine volume and urine pH were noted, the concentration of sodium and potassium was estimated by flame photometry, and diuretic index, natriuretic index, and Lipschitz values were calculated from the results. Furosemide was used as a positive control. Ethylene glycol-induced urolithiasis model was used for antiurolithiatic study. Urine volume, urine pH, body weight, and biochemical parameters such as calcium, urea, uric acid, and creatine both from serum and urine were estimated. Antioxidant parameters and histopathological analysis of the kidney were evaluated. Cystone was used as a positive control in this study. Results were expressed as mean ± standard error of mean. Statistical analysis was carried out using one-way analysis of variance, followed by Dunnett's multiple comparison tests. In both diuretic and antiurolithiatic studies, both doses of the extract showed efficacy, and the dose of 500 mg/kg has shown a significant effect compared to positive control and negative control. The dose of 500 mg/kg showed a promising diuretic and antiurolithiatic activity.
Identifiants
pubmed: 32874002
doi: 10.4103/ijp.IJP_92_18
pii: IJPharm-52-196
pmc: PMC7446677
doi:
Substances chimiques
Diuretics
0
Plant Extracts
0
Ethylene Glycol
FC72KVT52F
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
196-202Informations de copyright
Copyright: © 2020 Indian Journal of Pharmacology.
Déclaration de conflit d'intérêts
There are no conflicts of interest.
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