Carotenoids in Cancer Apoptosis-The Road
ROS
anti-cancer therapy
apoptosis
bioavailability
cancer cells
carotenoids
chemoprevention
complementary medicine
extrinsic pathway
individualized patient profiling
intrinsic pathway
nanotechnology
nutritional supplement
patient stratification
phytochemicals
plant substances
predictive preventive personalized medicine (PPPM/3PM)
programmed cell death
sensitizers
solubility
targeted treatment
vitamins
Journal
Cancers
ISSN: 2072-6694
Titre abrégé: Cancers (Basel)
Pays: Switzerland
ID NLM: 101526829
Informations de publication
Date de publication:
26 Aug 2020
26 Aug 2020
Historique:
received:
29
06
2020
revised:
21
08
2020
accepted:
23
08
2020
entrez:
30
8
2020
pubmed:
30
8
2020
medline:
30
8
2020
Statut:
epublish
Résumé
An incidence and mortality of cancer are rapidly growing worldwide, especially due to heterogeneous character of the disease that is associated with irreversible impairment of cellular homeostasis and function. Targeting apoptosis, one of cancer hallmarks, represents a potent cancer treatment strategy. Carotenoids are phytochemicals represented by carotenes, xanthophylls, and derived compounds such as apocarotenoids that demonstrate a broad spectrum of anti-cancer effects involving pro-apoptotic signaling through extrinsic and intrinsic pathways. As demonstrated in preclinical oncology research, the apoptotic modulation is performed at post-genomic levels. Further, carotenoids demonstrate additive/synergistic action in combination with conventional oncostatic agents. In addition, a sensitization of tumor cells to anti-cancer conventional treatment can be achieved by carotenoids. The disadvantage of anti-cancer application of carotenoids is associated with their low solubility and, therefore, poor bioavailability. However, this deficiency can be improved by using nanotechnological approaches, solid dispersions, microemulsions or biofortification that significantly increase the anti-cancer and pro-apoptotic efficacy of carotenoids. Only limited number of studies dealing with apoptotic potential of carotenoids has been published in clinical sphere. Pro-apoptotic effects of carotenoids should be beneficial for individuals at high risk of cancer development. The article considers the utility of carotenoids in the framework of 3P medicine.
Identifiants
pubmed: 32859058
pii: cancers12092425
doi: 10.3390/cancers12092425
pmc: PMC7563597
pii:
doi:
Types de publication
Journal Article
Review
Langues
eng
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