Computational design of transmembrane pores.

Cell Line Computer Simulation Cryoelectron Microscopy Crystallography, X-Ray Electric Conductivity Escherichia coli / genetics Genes, Synthetic / genetics Hydrazines Ion Channels / chemistry Ion Transport Liposomes / metabolism Models, Molecular Patch-Clamp Techniques Porins / chemistry Protein Engineering Protein Structure, Secondary Solubility Synthetic Biology Water / chemistry

Journal

Nature
ISSN: 1476-4687
Titre abrégé: Nature
Pays: England
ID NLM: 0410462

Informations de publication

Date de publication:
09 2020
Historique:
received: 24 08 2019
accepted: 29 05 2020
pubmed: 28 8 2020
medline: 21 10 2020
entrez: 28 8 2020
Statut: ppublish

Résumé

Transmembrane channels and pores have key roles in fundamental biological processes

Identifiants

DOI: 10.1038/s41586-020-2646-5 PMID: 32848250 PMC: PMC7483984
pubmed: 32848250
doi: 10.1038/s41586-020-2646-5
pii: 10.1038/s41586-020-2646-5
pmc: PMC7483984
mid: NIHMS1599393
doi:

Substances chimiques

Alexa 488 hydrazide 0
Hydrazines 0
Ion Channels 0
Liposomes 0
Porins 0
Water 059QF0KO0R

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, Non-P.H.S.

Langues

eng

Sous-ensembles de citation

IM

Pagination

129-134

Subventions

Organisme : NIGMS NIH HHS
ID : P30 GM124169
Pays : United States
Organisme : NINDS NIH HHS
ID : R35 NS111573
Pays : United States
Organisme : Wellcome Trust
ID : 200873/Z/16/Z
Pays : United Kingdom
Organisme : Wellcome Trust
Pays : United Kingdom
Organisme : Howard Hughes Medical Institute
Pays : United States
Organisme : NIGMS NIH HHS
ID : P30 GM124169-01
Pays : United States

Références

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Auteurs

Chunfu Xu (C)

Institute for Protein Design, University of Washington, Seattle, WA, USA.
Department of Biochemistry, University of Washington, Seattle, WA, USA.
Howard Hughes Medical Institute, University of Washington, Seattle, WA, USA.
ORCID: 0000-0002-8668-0566

Peilong Lu (P)

Institute for Protein Design, University of Washington, Seattle, WA, USA. lupeilong@westlake.edu.cn.
Department of Biochemistry, University of Washington, Seattle, WA, USA. lupeilong@westlake.edu.cn.
Zhejiang Provincial Laboratory of Life Sciences and Biomedicine, Key Laboratory of Structural Biology of Zhejiang Province, School of Life Sciences, Westlake University, Hangzhou, China. lupeilong@westlake.edu.cn.
Institute of Biology, Westlake Institute for Advanced Study, Hangzhou, China. lupeilong@westlake.edu.cn.
ORCID: 0000-0001-5894-9268

Tamer M Gamal El-Din (TM)

Department of Pharmacology, University of Washington, Seattle, WA, USA.

Xue Y Pei (XY)

Department of Biochemistry, University of Cambridge, Cambridge, UK.

Matthew C Johnson (MC)

Department of Biochemistry, University of Washington, Seattle, WA, USA.

Atsuko Uyeda (A)

Department of Biotechnology, Graduate School of Engineering, Osaka University, Suita, Japan.

Matthew J Bick (MJ)

Institute for Protein Design, University of Washington, Seattle, WA, USA.
Department of Biochemistry, University of Washington, Seattle, WA, USA.
Lyell Immunopharma, Inc., Seattle, WA, USA.

Qi Xu (Q)

Zhejiang Provincial Laboratory of Life Sciences and Biomedicine, Key Laboratory of Structural Biology of Zhejiang Province, School of Life Sciences, Westlake University, Hangzhou, China.
Institute of Biology, Westlake Institute for Advanced Study, Hangzhou, China.
ORCID: 0000-0002-9480-4776

Daohua Jiang (D)

Department of Pharmacology, University of Washington, Seattle, WA, USA.

Hua Bai (H)

Institute for Protein Design, University of Washington, Seattle, WA, USA.
Department of Biochemistry, University of Washington, Seattle, WA, USA.
ORCID: 0000-0002-0448-4052

Gabriella Reggiano (G)

Institute for Protein Design, University of Washington, Seattle, WA, USA.
Department of Biochemistry, University of Washington, Seattle, WA, USA.

Yang Hsia (Y)

Institute for Protein Design, University of Washington, Seattle, WA, USA.
Department of Biochemistry, University of Washington, Seattle, WA, USA.
ORCID: 0000-0001-7467-8373

T J Brunette (TJ)

Institute for Protein Design, University of Washington, Seattle, WA, USA.
Department of Biochemistry, University of Washington, Seattle, WA, USA.
ORCID: 0000-0003-0748-8224

Jiayi Dou (J)

Institute for Protein Design, University of Washington, Seattle, WA, USA.
Department of Biochemistry, University of Washington, Seattle, WA, USA.
Department of Bioengineering, Stanford University, Stanford, CA, USA.

Dan Ma (D)

Zhejiang Provincial Laboratory of Life Sciences and Biomedicine, Key Laboratory of Structural Biology of Zhejiang Province, School of Life Sciences, Westlake University, Hangzhou, China.
Institute of Biology, Westlake Institute for Advanced Study, Hangzhou, China.
Department of Biological Structure, University of Washington, Seattle, WA, USA.

Eric M Lynch (EM)

Department of Biochemistry, University of Washington, Seattle, WA, USA.
ORCID: 0000-0001-5897-5167

Scott E Boyken (SE)

Institute for Protein Design, University of Washington, Seattle, WA, USA.
Department of Biochemistry, University of Washington, Seattle, WA, USA.
Lyell Immunopharma, Inc., Seattle, WA, USA.
ORCID: 0000-0002-5378-0632

Po-Ssu Huang (PS)

Institute for Protein Design, University of Washington, Seattle, WA, USA.
Department of Biochemistry, University of Washington, Seattle, WA, USA.
Department of Bioengineering, Stanford University, Stanford, CA, USA.
ORCID: 0000-0002-7948-2895

Lance Stewart (L)

Institute for Protein Design, University of Washington, Seattle, WA, USA.
ORCID: 0000-0003-4264-5125

Frank DiMaio (F)

Institute for Protein Design, University of Washington, Seattle, WA, USA.
Department of Biochemistry, University of Washington, Seattle, WA, USA.

Justin M Kollman (JM)

Department of Biochemistry, University of Washington, Seattle, WA, USA.
ORCID: 0000-0002-0350-5827

Ben F Luisi (BF)

Department of Biochemistry, University of Cambridge, Cambridge, UK.
ORCID: 0000-0003-1144-9877

Tomoaki Matsuura (T)

Department of Biotechnology, Graduate School of Engineering, Osaka University, Suita, Japan.
ORCID: 0000-0003-1015-6781

William A Catterall (WA)

Department of Pharmacology, University of Washington, Seattle, WA, USA. wcatt@uw.edu.

David Baker (D)

Institute for Protein Design, University of Washington, Seattle, WA, USA. dabaker@uw.edu.
Department of Biochemistry, University of Washington, Seattle, WA, USA. dabaker@uw.edu.
Howard Hughes Medical Institute, University of Washington, Seattle, WA, USA. dabaker@uw.edu.
ORCID: 0000-0001-7896-6217

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Classifications MeSH

Recherchemedicale.com › Cellules › Cellules cultivées › Lignée cellulaire › Computational design of transmembrane pores.
Recherchemedicale.com › Sciences de l'information › Méthodologies informatiques › Simulation numérique › Computational design of transmembrane pores.
Recherchemedicale.com › Techniques d'investigation › Microscopie électronique › Cryomicroscopie électronique › Computational design of transmembrane pores.
Recherchemedicale.com › Techniques d'investigation › Techniques de chimie analytique › Cristallographie aux rayons X › Computational design of transmembrane pores.
Recherchemedicale.com › Phénomènes physiques › Phénomènes magnétiques › Phénomènes électromagnétiques › Électricité › Conductivité électrique › Computational design of transmembrane pores.
Recherchemedicale.com › Bactéries › Proteobacteria › Gammaproteobacteria › Enterobacteriaceae › Escherichia › Escherichia coli › Computational design of transmembrane pores.
Recherchemedicale.com › Phénomènes génétiques › Structures génétiques › Génome › Composants de génome › Gènes › Gènes de synthèse › Computational design of transmembrane pores.
Recherchemedicale.com › Composés chimiques organiques › Hydrazines › Computational design of transmembrane pores.
Recherchemedicale.com › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Protéines de transport membranaire › Canaux ioniques › Computational design of transmembrane pores.
Recherchemedicale.com › Métabolisme › Transport biologique › Transport des ions › Computational design of transmembrane pores.
Recherchemedicale.com › Technologie, industrie et agriculture › Produits manufacturés › Matériaux biomimétiques › Membrane artificielle › Liposomes › Computational design of transmembrane pores.
Recherchemedicale.com › Techniques d'investigation › Modèles théoriques › Modèles moléculaires › Computational design of transmembrane pores.
Recherchemedicale.com › Techniques d'investigation › Techniques cytologiques › Techniques de patch-clamp › Computational design of transmembrane pores.
Recherchemedicale.com › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Protéines de transport membranaire › Canaux ioniques › Porines › Computational design of transmembrane pores.
Recherchemedicale.com › Techniques d'investigation › Techniques génétiques › Génie génétique › Ingénierie des protéines › Computational design of transmembrane pores.
Recherchemedicale.com › Phénomènes chimiques › Phénomènes biochimiques › Conformation moléculaire › Conformation des protéines › Structure secondaire des protéines › Computational design of transmembrane pores.
Recherchemedicale.com › Phénomènes chimiques › Solubilité › Computational design of transmembrane pores.
Recherchemedicale.com › Technologie, industrie et agriculture › Ingénierie › Bioingénierie › Biologie synthétique › Computational design of transmembrane pores.
Recherchemedicale.com › Produits chimiques inorganiques › Composés de l'oxygène › Oxydes › Eau › Computational design of transmembrane pores.