Hormonal determinants of mammographic density and density change.

Adrenal Cortex Hormones / blood Breast / diagnostic imaging Breast Density Breast Neoplasms / diagnostic imaging Estrogens / blood Female Hormones / blood Humans Mammography / methods Middle Aged Postmenopause Premenopause Progesterone / blood Prolactin / blood Prospective Studies Risk Factors Testosterone / blood
Mammographic density Mammographic density change Plasma hormones

Journal

Breast cancer research : BCR
ISSN: 1465-542X
Titre abrégé: Breast Cancer Res
Pays: England
ID NLM: 100927353

Informations de publication

Date de publication:
26 08 2020
Historique:
received: 14 01 2020
accepted: 13 08 2020
entrez: 28 8 2020
pubmed: 28 8 2020
medline: 14 1 2021
Statut: epublish

Résumé

Mammographic density (MD) is a strong risk factor for breast cancer. We examined how endogenous plasma hormones are associated with average MD area (cm This study within the prospective KARMA cohort included analyses of plasma hormones of 1040 women. Hormones from the progestogen (n = 3), androgen (n = 7), oestrogen (n = 2) and corticoid (n = 5) pathways were analysed by ultra-performance supercritical fluid chromatography-tandem mass spectrometry (UPSFC-MS/MS), as well as peptide hormones and proteins (n = 2). MD was measured as a dense area using the STRATUS method (mean over the left and right breasts) and mean annual MD change over time. Greater baseline mean MD was associated with overall higher concentrations of progesterone (average + 1.29 cm Our results suggest that, whereas hormones from the progestogen, oestrogen and corticoid pathways drive baseline MD, MD change over time is mainly driven by androgens. This study emphasises the complexity of risk factors for breast cancer and their mechanisms of action.

Sections du résumé

BACKGROUND
Mammographic density (MD) is a strong risk factor for breast cancer. We examined how endogenous plasma hormones are associated with average MD area (cm
METHODS
This study within the prospective KARMA cohort included analyses of plasma hormones of 1040 women. Hormones from the progestogen (n = 3), androgen (n = 7), oestrogen (n = 2) and corticoid (n = 5) pathways were analysed by ultra-performance supercritical fluid chromatography-tandem mass spectrometry (UPSFC-MS/MS), as well as peptide hormones and proteins (n = 2). MD was measured as a dense area using the STRATUS method (mean over the left and right breasts) and mean annual MD change over time.
RESULTS
Greater baseline mean MD was associated with overall higher concentrations of progesterone (average + 1.29 cm
CONCLUSIONS
Our results suggest that, whereas hormones from the progestogen, oestrogen and corticoid pathways drive baseline MD, MD change over time is mainly driven by androgens. This study emphasises the complexity of risk factors for breast cancer and their mechanisms of action.

Identifiants

DOI: 10.1186/s13058-020-01332-4 PMID: 32847607 PMC: PMC7449090
pubmed: 32847607
doi: 10.1186/s13058-020-01332-4
pii: 10.1186/s13058-020-01332-4
pmc: PMC7449090
doi:

Substances chimiques

Adrenal Cortex Hormones 0
Estrogens 0
Hormones 0
Testosterone 3XMK78S47O
Progesterone 4G7DS2Q64Y
Prolactin 9002-62-4

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

95

Subventions

Organisme : Vetenskapsrådet
ID : 2015-4870
Pays : International
Organisme : Vetenskapsrådet
ID : C820013143
Pays : International
Organisme : Märit and Hans Raussing Initiative Against Breast Cancer
ID : n.a.
Pays : International
Organisme : Familjen Kamprads Stiftelse (SE)
ID : n.a.
Pays : International

Références

Cancer Epidemiol Biomarkers Prev. 2005 Jun;14(6):1411-7
pubmed: 15941949
Cancer Epidemiol Biomarkers Prev. 2005 Nov;14(11 Pt 1):2641-7
pubmed: 16284390
Cancer Epidemiol Biomarkers Prev. 2006 Apr;15(4):732-9
pubmed: 16614116
Int J Cancer. 2007 Dec 1;121(11):2506-11
pubmed: 17657735
Eur J Cancer Prev. 2016 Jan;25(1):9-18
pubmed: 25714648
Cancer Epidemiol Biomarkers Prev. 2006 Jun;15(6):1159-69
pubmed: 16775176
Cancer Epidemiol Biomarkers Prev. 2019 Jan;28(1):41-50
pubmed: 30068518
J Natl Cancer Inst. 2005 Sep 21;97(18):1366-76
pubmed: 16174858
Climacteric. 2005 Jun;8(2):185-92
pubmed: 16096175
Ann Intern Med. 1999 Feb 16;130(4 Pt 1):262-9
pubmed: 10068383
J Natl Cancer Inst. 2007 Aug 1;99(15):1178-87
pubmed: 17652278
JNCI Cancer Spectr. 2018 Dec 04;2(4):pky055
pubmed: 31360875
J Clin Oncol. 2009 Dec 20;27(36):6135-43
pubmed: 19901118
Breast Cancer Res. 2007;9(4):R53
pubmed: 17692133
Cancer Epidemiol Biomarkers Prev. 2018 Dec;27(12):1500-1508
pubmed: 30228153
J Natl Cancer Inst. 2003 Jan 1;95(1):30-7
pubmed: 12509398
J Natl Cancer Inst. 2002 Apr 17;94(8):606-16
pubmed: 11959894
J Natl Cancer Inst. 1995 May 3;87(9):670-5
pubmed: 7752271
Breast Cancer Res Treat. 2008 Mar;108(1):57-67
pubmed: 17468953
Best Pract Res Clin Endocrinol Metab. 2015 Oct;29(5):749-60
pubmed: 26522459
JNCI Cancer Spectr. 2019 Feb 04;3(1):pkz004
pubmed: 31360892
Horm Cancer. 2018 Apr;9(2):117-127
pubmed: 29330698
Int J Epidemiol. 2019 Jun 1;48(3):807-816
pubmed: 31143958
Br J Cancer. 2014 Apr 2;110(7):1898-907
pubmed: 24518596
Br J Cancer. 2002 Oct 7;87(8):876-82
pubmed: 12373602
J Mol Endocrinol. 2015 Apr;54(2):R31-53
pubmed: 25587053
Am J Epidemiol. 2005 Nov 1;162(9):826-34
pubmed: 16177147
Breast Cancer Res. 2017 Mar 14;19(1):29
pubmed: 28288659
Cancer Epidemiol Biomarkers Prev. 2020 Mar;29(3):574-581
pubmed: 31948996
J Natl Cancer Inst. 2006 Oct 4;98(19):1406-15
pubmed: 17018787
Cancer Epidemiol Biomarkers Prev. 2009 Jan;18(1):102-12
pubmed: 19124487
AJR Am J Roentgenol. 2012 Mar;198(3):W292-5
pubmed: 22358028
N Engl J Med. 2007 Jan 18;356(3):227-36
pubmed: 17229950
JAMA. 2003 Jun 25;289(24):3243-53
pubmed: 12824205
Breast Cancer Res Treat. 2007 Nov;105(3):337-46
pubmed: 17260098
Horm Metab Res. 2015 Jun;47(7):485-90
pubmed: 25565095
Am J Epidemiol. 2008 May 1;167(9):1027-36
pubmed: 18385204
Int J Cancer. 2004 Nov 1;112(2):312-8
pubmed: 15352045
J Natl Cancer Inst. 1995 Nov 1;87(21):1622-9
pubmed: 7563205
Int J Epidemiol. 2017 Dec 1;46(6):1740-1741g
pubmed: 28180256
Cancer Epidemiol Biomarkers Prev. 2010 Apr;19(4):1112-21
pubmed: 20332266
J Natl Cancer Inst. 2004 Apr 21;96(8):621-8
pubmed: 15100340
J Natl Cancer Inst. 2005 May 18;97(10):755-65
pubmed: 15900045
Cancer Epidemiol Biomarkers Prev. 2008 Jul;17(7):1674-81
pubmed: 18628419
Sci Rep. 2018 Nov 19;8(1):16993
pubmed: 30451874
Cancer Epidemiol Biomarkers Prev. 2005 Jan;14(1):33-40
pubmed: 15668473
Breast. 2006 Feb;15(1):20-8
pubmed: 16000251
JAMA. 2001 Jan 10;285(2):171-6
pubmed: 11176809

Auteurs

Marike Gabrielson (M)

Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Nobels väg 12A, SE-171 77, Stockholm, Sweden. marike.gabrielson@ki.se.
ORCID: 0000-0002-3171-1556

Shadi Azam (S)

Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Nobels väg 12A, SE-171 77, Stockholm, Sweden.

Elina Hardell (E)

Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Nobels väg 12A, SE-171 77, Stockholm, Sweden.

Madeleine Holm (M)

Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Nobels väg 12A, SE-171 77, Stockholm, Sweden.

Kumari A Ubhayasekera (KA)

Analytical Chemistry and Neurochemistry, Department of Chemistry - BMC, Uppsala University, Uppsala, Sweden.

Mikael Eriksson (M)

Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Nobels väg 12A, SE-171 77, Stockholm, Sweden.

Magnus Bäcklund (M)

Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Nobels väg 12A, SE-171 77, Stockholm, Sweden.

Jonas Bergquist (J)

Analytical Chemistry and Neurochemistry, Department of Chemistry - BMC, Uppsala University, Uppsala, Sweden.

Kamila Czene (K)

Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Nobels väg 12A, SE-171 77, Stockholm, Sweden.

Per Hall (P)

Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Nobels väg 12A, SE-171 77, Stockholm, Sweden.
Department of Oncology, South General Hospital, Stockholm, Sweden.

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Classifications MeSH

Recherchemedicale.com › Hormones corticosurrénaliennes › Hormonal determinants of mammographic density...
Recherchemedicale.com › Régions du corps › Région mammaire › Hormonal determinants of mammographic density...
Recherchemedicale.com › Phénomènes physiologiques › Constitution physique › Densité mammaire › Hormonal determinants of mammographic density...
Recherchemedicale.com › Maladies de la peau et du tissu conjonctif › Maladies de la peau › Maladies du sein › Tumeurs du sein › Hormonal determinants of mammographic density...
Recherchemedicale.com › Actions chimiques et utilisations › Actions pharmacologiques › Effets physiologiques des médicaments › Hormones, substituts d'hormones et antagonistes d'hormones › Hormones › Oestrogènes › Hormonal determinants of mammographic density...
Recherchemedicale.com › Actions chimiques et utilisations › Actions pharmacologiques › Effets physiologiques des médicaments › Hormones, substituts d'hormones et antagonistes d'hormones › Hormones › Hormonal determinants of mammographic density...
Recherchemedicale.com › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Hormonal determinants of mammographic density...
Recherchemedicale.com › Diagnostic › Techniques et procédures diagnostiques › Imagerie diagnostique › Radiographie › Mammographie › Hormonal determinants of mammographic density...
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Recherchemedicale.com › Phénomènes physiologiques des appareils urinaire et reproducteur › Phénomènes physiologiques de la reproduction › Développement sexuel › Climatère › Ménopause › Post-ménopause › Hormonal determinants of mammographic density...
Recherchemedicale.com › Phénomènes physiologiques des appareils urinaire et reproducteur › Phénomènes physiologiques de la reproduction › Développement sexuel › Climatère › Ménopause › Préménopause › Hormonal determinants of mammographic density...
Recherchemedicale.com › Hormones gonadiques › Hormones sexuelles stéroïdiennes › Congénères de la progestérone › Progestérone › Hormonal determinants of mammographic density...
Recherchemedicale.com › Acides aminés, peptides et protéines › Peptides › Hormones peptidiques › Hormones hypophysaires › Hormones antéhypophysaires › Prolactine › Hormonal determinants of mammographic density...
Recherchemedicale.com › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Caractéristiques des études épidémiologiques › Études épidémiologiques › Études de cohortes › Études prospectives › Hormonal determinants of mammographic density...
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Recherchemedicale.com › Hormones gonadiques › Hormones sexuelles stéroïdiennes › Congénères de la testostérone › Testostérone › Hormonal determinants of mammographic density...