Colchicine as a Potential Therapeutic Agent Against Cardiovascular Complications of COVID-19: an Exploratory Review.
COVID-19
CVD
Cardiovascular disease
Colchicine
Coronavirus
Virus
Journal
SN comprehensive clinical medicine
ISSN: 2523-8973
Titre abrégé: SN Compr Clin Med
Pays: Switzerland
ID NLM: 101740833
Informations de publication
Date de publication:
2020
2020
Historique:
accepted:
17
07
2020
pubmed:
25
8
2020
medline:
25
8
2020
entrez:
25
8
2020
Statut:
ppublish
Résumé
Coronavirus disease-19 (COVID-19) may result in serious complications involving several organ systems, including myocardial tissue. An exaggerated host inflammatory response, described as a cytokine storm, has been linked to play a major role in these complications. Colchicine and other pharmaceutical agents have been proposed to counter the cytokine storm and improve outcomes. In this exploratory review, we utilized a PubMed and Cochrane Database search aiming to identify the biochemical characteristics of the cytokine storm as well as to identify the potential effect of colchicine on these inflammatory biomarkers. The research yielded 30 reports describing the characteristics of the cytokine storm and 44 reports describing the effect of colchicine on various inflammatory biomarkers. According to our research, colchicine may be an agent of interest in the treatment of COVID-19 via its anti-inflammatory properties. However, there are potential drug interactions with cytochrome P450 3A4 inhibitors resulting in acute colchicine toxicities. Additionally, there is scarce evidence regarding the efficacy of colchicine in the acute phase of disease, since most trials evaluated its effect in chronic conditions. In this direction, our team proposes three different hypotheses for evaluating the place of colchicine in the treatment of COVID-19.
Identifiants
pubmed: 32838182
doi: 10.1007/s42399-020-00421-x
pii: 421
pmc: PMC7398860
doi:
Types de publication
Journal Article
Review
Langues
eng
Pagination
1419-1429Informations de copyright
© Springer Nature Switzerland AG 2020.
Déclaration de conflit d'intérêts
Conflict of InterestThe authors declare that they have no conflict of interest.
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