Repeatability and Reproducibility of Total Retinal Blood Flow Measurements Using Bi-Directional Doppler OCT.

Fourier Analysis Humans Regional Blood Flow Reproducibility of Results Retinal Vessels / diagnostic imaging Tomography, Optical Coherence
healthy subjects repeatability retinal blood flow

Journal

Translational vision science & technology
ISSN: 2164-2591
Titre abrégé: Transl Vis Sci Technol
Pays: United States
ID NLM: 101595919

Informations de publication

Date de publication:
06 2020
Historique:
received: 25 02 2020
accepted: 28 04 2020
entrez: 25 8 2020
pubmed: 25 8 2020
medline: 25 8 2020
Statut: epublish

Résumé

To investigate the repeatability and reproducibility of total retinal blood flow measurements using a custom-built dual-beam bidirectional Doppler optical coherence tomography (OCT) system in healthy subjects. Repeatability and reproducibility were analyzed in 10 and 34 healthy subjects, respectively. For repeatability, measurements were taken twice within 30 minutes, for reproducibility, twice within two to five weeks. Two analysis approaches were compared for calculation of absolute blood velocities: a previously published approach resulting in values for total arterial (Q For Q Measurement of total retinal blood flow using dual-beam Doppler OCT shows excellent reproducibility, which can further be improved by using a novel algorithm for calculating blood velocities in retinal vessels. Our data indicate that dual-beam Doppler OCT can be used for longitudinal studies. Hence, quantitative retinal blood flow may be established as a biomarker for progression vascular eye diseases.

Identifiants

DOI: 10.1167/tvst.9.7.34 PMID: 32832239 PMC: PMC7414639
pubmed: 32832239
doi: 10.1167/tvst.9.7.34
pii: TVST-20-2364
pmc: PMC7414639
doi:

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Pagination

34

Subventions

Organisme : Austrian Science Fund FWF
ID : KLI 529
Pays : Austria

Informations de copyright

Copyright 2020 The Authors.

Déclaration de conflit d'intérêts

Disclosure: S. Szegedi, None; N. Hommer, None; M. Kallab, None; S. Puchner, None; D. Schmidl, None; R.M. Werkmeister, None; G. Garhöfer, None; L. Schmetterer, None

Références

Invest Ophthalmol Vis Sci. 2012 Feb 13;53(2):698-703
pubmed: 22247463
Invest Ophthalmol Vis Sci. 2012 Sep 12;53(10):6062-71
pubmed: 22893675
Eye (Lond). 2019 Feb;33(2):320-326
pubmed: 30206418
Br J Ophthalmol. 2018 Jan;102(1):126-130
pubmed: 28495904
Prog Retin Eye Res. 2012 Sep;31(5):377-406
pubmed: 22580107
PLoS One. 2012;7(9):e45876
pubmed: 23029289
Diabetes Care. 2010 Sep;33(9):2038-42
pubmed: 20585003
Diabetologia. 2017 Dec;60(12):2361-2367
pubmed: 28884200
Graefes Arch Clin Exp Ophthalmol. 2001 Sep;239(9):673-7
pubmed: 11688666
Biomed Opt Express. 2016 Nov 23;7(12):5233-5251
pubmed: 28018739
Prog Retin Eye Res. 2017 Sep;60:66-100
pubmed: 28760677
Ophthalmology. 1996 Mar;103(3):529-34
pubmed: 8600432
Ophthalmic Surg Lasers Imaging. 2012 Jan-Feb;43(1):25-31
pubmed: 22251842
Invest Ophthalmol Vis Sci. 2015 Feb 10;56(3):1569-74
pubmed: 25670487
J Biomed Opt. 2013 Nov;18(11):116010
pubmed: 24247747
Acta Ophthalmol. 2009 Nov;87(8):875-80
pubmed: 18976308
Am J Ophthalmol. 2017 Oct;182:118-125
pubmed: 28739419
Curr Opin Pharmacol. 2013 Feb;13(1):36-42
pubmed: 23009741
Invest Ophthalmol Vis Sci. 1985 Aug;26(8):1124-32
pubmed: 4019103
Am J Ophthalmol. 2019 Jul;203:103-115
pubmed: 30689991
PLoS One. 2016 Dec 13;11(12):e0168190
pubmed: 27959905
Prog Retin Eye Res. 2008 May;27(3):284-330
pubmed: 18448380
Invest Ophthalmol Vis Sci. 2017 Jun 1;58(7):2891-2898
pubmed: 28586913
Biomed Opt Express. 2016 Jan 06;7(2):287-301
pubmed: 26977340
J Chiropr Med. 2016 Jun;15(2):155-63
pubmed: 27330520
Curr Diab Rep. 2017 Aug 8;17(10):82
pubmed: 28791532
Invest Ophthalmol Vis Sci. 2015 Apr;56(4):2522-30
pubmed: 25744974
Exp Eye Res. 1992 Sep;55(3):499-506
pubmed: 1426079
Invest Ophthalmol Vis Sci. 2017 Jul 1;58(9):3804-3817
pubmed: 28744554
Invest Ophthalmol Vis Sci. 2010 Dec;51(12):6652-7
pubmed: 20688735
Invest Ophthalmol Vis Sci. 2016 Jul 1;57(9):OCT121-9
pubmed: 27409462
Acta Ophthalmol. 2019 Jun;97(4):e487-e492
pubmed: 30315616
Opt Lett. 2008 Dec 15;33(24):2967-9
pubmed: 19079508
Asia Pac J Ophthalmol (Phila). 2016 Jan-Feb;5(1):38-44
pubmed: 26886118
Ultrasound Med Biol. 2005 Jul;31(7):895-903
pubmed: 15972195
Invest Ophthalmol Vis Sci. 2018 Apr 1;59(5):2167-2176
pubmed: 29801151
Invest Ophthalmol Vis Sci. 2014 May 06;55(7):4266-76
pubmed: 24801513
Clin Exp Optom. 2019 May;102(3):260-269
pubmed: 30537233
Ophthalmic Res. 2018;60(3):139-151
pubmed: 29794471
Invest Ophthalmol Vis Sci. 2016 Mar;57(3):1432-40
pubmed: 27031838
Invest Ophthalmol Vis Sci. 2013 Jan 30;54(1):842-7
pubmed: 23307962
Surv Ophthalmol. 2018 Nov - Dec;63(6):816-850
pubmed: 29705175
Sci Rep. 2015 Oct 27;5:15763
pubmed: 26503332
Invest Ophthalmol Vis Sci. 2019 Jul 1;60(8):3162-3169
pubmed: 31335953
Acta Ophthalmol. 2012 Dec;90(8):e616-20
pubmed: 22938808
Curr Eye Res. 2015 Feb;40(2):201-12
pubmed: 24892919
Acta Ophthalmol. 2018 Jun;96(4):e485-e492
pubmed: 29575676
Prog Retin Eye Res. 2014 Jul;41:26-43
pubmed: 24704352
Invest Ophthalmol Vis Sci. 1994 Dec;35(13):4273-81
pubmed: 8002247
Diabetologia. 2017 Aug;60(8):1534-1540
pubmed: 28547132
Biomed Opt Express. 2014 Jan 28;5(2):630-42
pubmed: 24575355
J Biomed Opt. 2015 Jun;20(6):066004
pubmed: 26062663
Prog Retin Eye Res. 2018 May;64:1-55
pubmed: 29229445
Jpn J Ophthalmol. 1996;40(3):339-43
pubmed: 8988423
J Biomed Opt. 2007 Jul-Aug;12(4):041215
pubmed: 17867804

Auteurs

Stephan Szegedi (S)

Department of Clinical Pharmacology, Medical University of Vienna, Austria.

Nikolaus Hommer (N)

Department of Clinical Pharmacology, Medical University of Vienna, Austria.

Martin Kallab (M)

Department of Clinical Pharmacology, Medical University of Vienna, Austria.

Stefan Puchner (S)

Department of Clinical Pharmacology, Medical University of Vienna, Austria.
Center for Medical Physics and Biomedical Engineering, Medical University of Vienna, Austria.

Doreen Schmidl (D)

Department of Clinical Pharmacology, Medical University of Vienna, Austria.

René M Werkmeister (RM)

Center for Medical Physics and Biomedical Engineering, Medical University of Vienna, Austria.

Gerhard Garhöfer (G)

Department of Clinical Pharmacology, Medical University of Vienna, Austria.

Leopold Schmetterer (L)

Department of Clinical Pharmacology, Medical University of Vienna, Austria.
Center for Medical Physics and Biomedical Engineering, Medical University of Vienna, Austria.
Singapore Eye Research Institute, Singapore National Eye Centre, Singapore.
School of Chemical and Biomedical Engineering, Nanyang Technological University, Singapore.
SERI-NTU Advanced Ocular Engineering (STANCE), Singapore.
Ophthalmology and Visual Sciences Academic Clinical Program, Duke-NUS Medical School, Singapore.
Institute of Clinical and Experimental Ophthalmology, Basel, Switzerland.

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Classifications MeSH

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Recherchemedicale.com › Techniques d'investigation › Imagerie optique › Tomographie optique › Tomographie par cohérence optique › Repeatability and Reproducibility of Total...