Discovery of a Small Molecule Drug Candidate for Selective NKCC1 Inhibition in Brain Disorders.
Down syndrome
GABAergic transmission
KCC2
NKCC1
NKCC2
autism
brain disorders
chloride homeostasis
drug discovery
small molecule
Journal
Chem
ISSN: 2451-9294
Titre abrégé: Chem
Pays: United States
ID NLM: 101688902
Informations de publication
Date de publication:
06 Aug 2020
06 Aug 2020
Historique:
received:
13
02
2020
revised:
14
04
2020
accepted:
11
06
2020
entrez:
21
8
2020
pubmed:
21
8
2020
medline:
21
8
2020
Statut:
epublish
Résumé
Aberrant expression ratio of Cl
Identifiants
pubmed: 32818158
doi: 10.1016/j.chempr.2020.06.017
pii: S2451-9294(20)30298-9
pmc: PMC7427514
doi:
Types de publication
Journal Article
Langues
eng
Pagination
2073-2096Subventions
Organisme : Telethon
ID : TCP15021
Pays : Italy
Commentaires et corrections
Type : CommentIn
Informations de copyright
© 2020 The Authors.
Déclaration de conflit d'intérêts
A.C. and L.C. are named as co-inventors on the following granted patent: US 9,822,368; EP 3083959; JP 6490077; A.C. and L.C. are named as co-inventors on the patent application WO 2018/189225. A.S., M.B., J.A.O., A.C., M.D.V., and L.C. are named as co-inventors on patent application IT 102019000004929.
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