Genetic and Epigenetic Regulation of the Smoothened Gene (SMO) in Cancer Cells.

hedgehog pathway methylation promoter smoothened transcription factors

Journal

Cancers
ISSN: 2072-6694
Titre abrégé: Cancers (Basel)
Pays: Switzerland
ID NLM: 101526829

Informations de publication

Date de publication:
08 Aug 2020
Historique:
received: 29 05 2020
revised: 17 07 2020
accepted: 28 07 2020
entrez: 14 8 2020
pubmed: 14 8 2020
medline: 14 8 2020
Statut: epublish

Résumé

(1) Background: The hedgehog (HH) signaling pathway is a key regulator of embryonic patterning, tissue regeneration, stem cell renewal, and cancer growth. The smoothened (SMO) protein regulates the HH signaling pathway and has demonstrated oncogenic activity. (2) Methods: To clarify the role of the HH signaling pathway in tumorigenesis, the expression profile of key HH signaling molecules, including

Identifiants

pubmed: 32784501
pii: cancers12082219
doi: 10.3390/cancers12082219
pmc: PMC7464114
pii:
doi:

Types de publication

Journal Article

Langues

eng

Subventions

Organisme : CCR NIH HHS
ID : HHSN261200800001C
Pays : United States
Organisme : NCI NIH HHS
ID : HHSN261200800001E
Pays : United States
Organisme : NIH HHS
ID : LTG10410-Dean
Pays : United States

Références

J Med Chem. 2007 Sep 6;50(18):4534-8
pubmed: 17685505
Nature. 2003 Mar 20;422(6929):313-7
pubmed: 12629553
EMBO J. 2003 Jun 2;22(11):2741-51
pubmed: 12773389
World J Gastroenterol. 2009 Aug 14;15(30):3799-806
pubmed: 19673023
Biomed Pharmacother. 2017 Jan;85:264-271
pubmed: 27887846
Nature. 2003 Oct 23;425(6960):851-6
pubmed: 14520413
Genes Chromosomes Cancer. 2020 Feb;59(2):73-83
pubmed: 31408253
Medicine (Baltimore). 1987 Mar;66(2):98-113
pubmed: 3547011
Future Med Chem. 2019 Mar;11(6):617-638
pubmed: 30912670
Mol Interv. 2006 Jun;6(3):140-8
pubmed: 16809475
PLoS One. 2010 Jun 11;5(6):e11024
pubmed: 20552011
Nucleic Acids Res. 2004 Jul 1;32(Web Server issue):W273-9
pubmed: 15215394
Nat Rev Cancer. 2004 Dec;4(12):988-93
pubmed: 15573120
Oncogene. 2007 Feb 26;26(9):1357-60
pubmed: 17322922
Mol Cell Proteomics. 2014 Feb;13(2):397-406
pubmed: 24309898
Breast Cancer Res Treat. 2007 Oct;105(2):139-55
pubmed: 17295047
Biochim Biophys Acta. 1997 Apr 18;1332(2):M43-52
pubmed: 9141460
Nature. 1994 Sep 29;371(6496):435-8
pubmed: 8090226
Nature. 2004 Oct 7;431(7009):707-12
pubmed: 15361885
Development. 2007 May;134(10):1977-89
pubmed: 17442700
Head Face Med. 2014 Sep 05;10:36
pubmed: 25189937
Cell Physiol Biochem. 2017;42(6):2430-2440
pubmed: 28848211
Nature. 2003 Oct 23;425(6960):846-51
pubmed: 14520411
PLoS Genet. 2008 Nov;4(11):e1000254
pubmed: 19008943
Cell. 2002 Mar 22;108(6):823-35
pubmed: 11955435
Nature. 2004 Nov 18;432(7015):324-31
pubmed: 15549094
Proc Natl Acad Sci U S A. 1999 Jul 20;96(15):8681-6
pubmed: 10411935
Nature. 2002 Aug 29;418(6901):979-83
pubmed: 12198547
Cell. 2000 Feb 18;100(4):423-34
pubmed: 10693759
J Vis Exp. 2012 May 22;(63):e3998
pubmed: 22664923
Oncol Lett. 2018 Nov;16(5):6407-6416
pubmed: 30405777
Proc Natl Acad Sci U S A. 2009 May 12;106(19):7933-8
pubmed: 19383797
Curr Opin Investig Drugs. 2010 Jun;11(6):707-18
pubmed: 20496266
Cancer Res. 2005 Dec 1;65(23):10822-9
pubmed: 16322228
Nature. 2007 Feb 15;445(7129):761-5
pubmed: 17230190
Science. 2002 Aug 30;297(5586):1559-61
pubmed: 12202832
Drugs. 2015 Sep;75(13):1559-66
pubmed: 26323341
Clin Cancer Res. 2006 Oct 15;12(20 Pt 1):5924-8
pubmed: 17062662
Front Genet. 2019 Jun 12;10:556
pubmed: 31244888
Cancer Res. 2010 Feb 15;70(4):1398-407
pubmed: 20145141
Nat Genet. 2003 Mar;33 Suppl:245-54
pubmed: 12610534
Chembiochem. 2011 Apr 11;12(6):914-21
pubmed: 21365731
Cell Res. 2012 Nov;22(11):1593-604
pubmed: 22986504
J Cancer Res Clin Oncol. 2009 Feb;135(2):235-40
pubmed: 18636275
Proc Natl Acad Sci U S A. 2019 Jan 15;116(3):874-879
pubmed: 30598432
Cancer Lett. 2004 Apr 30;207(2):205-14
pubmed: 15072830
J Immunol Methods. 2004 Mar;286(1-2):203-17
pubmed: 15087233
Development. 2005 Oct;132(19):4339-51
pubmed: 16141219
Genes Dev. 2001 Dec 1;15(23):3059-87
pubmed: 11731473
J Clin Invest. 2019 Feb 1;129(2):465-475
pubmed: 30707108
Bioinformatics. 2005 Nov 1;21(21):4067-8
pubmed: 16141249

Auteurs

Hong Lou (H)

Laboratory of Translational Genomics, Division of Cancer Epidemiology and Genetics, Leidos Biomedical Research, Inc., National Laboratory for Cancer Research, Gaithersburg, MD 20892, USA.

Hongchuan Li (H)

Basic Science Program, Frederick National Laboratory for Cancer Research, Frederick, MD 21702, USA.

Andrew R Huehn (AR)

Laboratory of Cancer Immunometabolism, Center for Cancer Research, National Cancer Institute, Frederick, MD 21702, USA.
Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, CT 06510, USA.

Nadya I Tarasova (NI)

Laboratory of Cancer Immunometabolism, Center for Cancer Research, National Cancer Institute, Frederick, MD 21702, USA.

Bahara Saleh (B)

Laboratory of Cancer Immunometabolism, Center for Cancer Research, National Cancer Institute, Frederick, MD 21702, USA.

Stephen K Anderson (SK)

Basic Science Program, Frederick National Laboratory for Cancer Research, Frederick, MD 21702, USA.
Laboratory of Cancer Immunometabolism, Center for Cancer Research, National Cancer Institute, Frederick, MD 21702, USA.

Michael Dean (M)

Laboratory of Translational Genomics, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Gaithersburg, MD 20892, USA.

Classifications MeSH