Genetic and Epigenetic Regulation of the Smoothened Gene (SMO) in Cancer Cells.
hedgehog pathway
methylation
promoter
smoothened
transcription factors
Journal
Cancers
ISSN: 2072-6694
Titre abrégé: Cancers (Basel)
Pays: Switzerland
ID NLM: 101526829
Informations de publication
Date de publication:
08 Aug 2020
08 Aug 2020
Historique:
received:
29
05
2020
revised:
17
07
2020
accepted:
28
07
2020
entrez:
14
8
2020
pubmed:
14
8
2020
medline:
14
8
2020
Statut:
epublish
Résumé
(1) Background: The hedgehog (HH) signaling pathway is a key regulator of embryonic patterning, tissue regeneration, stem cell renewal, and cancer growth. The smoothened (SMO) protein regulates the HH signaling pathway and has demonstrated oncogenic activity. (2) Methods: To clarify the role of the HH signaling pathway in tumorigenesis, the expression profile of key HH signaling molecules, including
Identifiants
pubmed: 32784501
pii: cancers12082219
doi: 10.3390/cancers12082219
pmc: PMC7464114
pii:
doi:
Types de publication
Journal Article
Langues
eng
Subventions
Organisme : CCR NIH HHS
ID : HHSN261200800001C
Pays : United States
Organisme : NCI NIH HHS
ID : HHSN261200800001E
Pays : United States
Organisme : NIH HHS
ID : LTG10410-Dean
Pays : United States
Références
J Med Chem. 2007 Sep 6;50(18):4534-8
pubmed: 17685505
Nature. 2003 Mar 20;422(6929):313-7
pubmed: 12629553
EMBO J. 2003 Jun 2;22(11):2741-51
pubmed: 12773389
World J Gastroenterol. 2009 Aug 14;15(30):3799-806
pubmed: 19673023
Biomed Pharmacother. 2017 Jan;85:264-271
pubmed: 27887846
Nature. 2003 Oct 23;425(6960):851-6
pubmed: 14520413
Genes Chromosomes Cancer. 2020 Feb;59(2):73-83
pubmed: 31408253
Medicine (Baltimore). 1987 Mar;66(2):98-113
pubmed: 3547011
Future Med Chem. 2019 Mar;11(6):617-638
pubmed: 30912670
Mol Interv. 2006 Jun;6(3):140-8
pubmed: 16809475
PLoS One. 2010 Jun 11;5(6):e11024
pubmed: 20552011
Nucleic Acids Res. 2004 Jul 1;32(Web Server issue):W273-9
pubmed: 15215394
Nat Rev Cancer. 2004 Dec;4(12):988-93
pubmed: 15573120
Oncogene. 2007 Feb 26;26(9):1357-60
pubmed: 17322922
Mol Cell Proteomics. 2014 Feb;13(2):397-406
pubmed: 24309898
Breast Cancer Res Treat. 2007 Oct;105(2):139-55
pubmed: 17295047
Biochim Biophys Acta. 1997 Apr 18;1332(2):M43-52
pubmed: 9141460
Nature. 1994 Sep 29;371(6496):435-8
pubmed: 8090226
Nature. 2004 Oct 7;431(7009):707-12
pubmed: 15361885
Development. 2007 May;134(10):1977-89
pubmed: 17442700
Head Face Med. 2014 Sep 05;10:36
pubmed: 25189937
Cell Physiol Biochem. 2017;42(6):2430-2440
pubmed: 28848211
Nature. 2003 Oct 23;425(6960):846-51
pubmed: 14520411
PLoS Genet. 2008 Nov;4(11):e1000254
pubmed: 19008943
Cell. 2002 Mar 22;108(6):823-35
pubmed: 11955435
Nature. 2004 Nov 18;432(7015):324-31
pubmed: 15549094
Proc Natl Acad Sci U S A. 1999 Jul 20;96(15):8681-6
pubmed: 10411935
Nature. 2002 Aug 29;418(6901):979-83
pubmed: 12198547
Cell. 2000 Feb 18;100(4):423-34
pubmed: 10693759
J Vis Exp. 2012 May 22;(63):e3998
pubmed: 22664923
Oncol Lett. 2018 Nov;16(5):6407-6416
pubmed: 30405777
Proc Natl Acad Sci U S A. 2009 May 12;106(19):7933-8
pubmed: 19383797
Curr Opin Investig Drugs. 2010 Jun;11(6):707-18
pubmed: 20496266
Cancer Res. 2005 Dec 1;65(23):10822-9
pubmed: 16322228
Nature. 2007 Feb 15;445(7129):761-5
pubmed: 17230190
Science. 2002 Aug 30;297(5586):1559-61
pubmed: 12202832
Drugs. 2015 Sep;75(13):1559-66
pubmed: 26323341
Clin Cancer Res. 2006 Oct 15;12(20 Pt 1):5924-8
pubmed: 17062662
Front Genet. 2019 Jun 12;10:556
pubmed: 31244888
Cancer Res. 2010 Feb 15;70(4):1398-407
pubmed: 20145141
Nat Genet. 2003 Mar;33 Suppl:245-54
pubmed: 12610534
Chembiochem. 2011 Apr 11;12(6):914-21
pubmed: 21365731
Cell Res. 2012 Nov;22(11):1593-604
pubmed: 22986504
J Cancer Res Clin Oncol. 2009 Feb;135(2):235-40
pubmed: 18636275
Proc Natl Acad Sci U S A. 2019 Jan 15;116(3):874-879
pubmed: 30598432
Cancer Lett. 2004 Apr 30;207(2):205-14
pubmed: 15072830
J Immunol Methods. 2004 Mar;286(1-2):203-17
pubmed: 15087233
Development. 2005 Oct;132(19):4339-51
pubmed: 16141219
Genes Dev. 2001 Dec 1;15(23):3059-87
pubmed: 11731473
J Clin Invest. 2019 Feb 1;129(2):465-475
pubmed: 30707108
Bioinformatics. 2005 Nov 1;21(21):4067-8
pubmed: 16141249