MicroRNA-222 Regulates Melanoma Plasticity.
cancer stem cells
hsa-mir-222
kinetic equations
melanoma
phenotypic switching
reaction diffusion
tumor plasticity
Journal
Journal of clinical medicine
ISSN: 2077-0383
Titre abrégé: J Clin Med
Pays: Switzerland
ID NLM: 101606588
Informations de publication
Date de publication:
08 Aug 2020
08 Aug 2020
Historique:
received:
08
07
2020
revised:
31
07
2020
accepted:
31
07
2020
entrez:
14
8
2020
pubmed:
14
8
2020
medline:
14
8
2020
Statut:
epublish
Résumé
Melanoma is one of the most aggressive and highly resistant tumors. Cell plasticity in melanoma is one of the main culprits behind its metastatic capabilities. The detailed molecular mechanisms controlling melanoma plasticity are still not completely understood. Here we combine mathematical models of phenotypic switching with experiments on IgR39 human melanoma cells to identify possible key targets to impair phenotypic switching. Our mathematical model shows that a cancer stem cell subpopulation within the tumor prevents phenotypic switching of the other cancer cells. Experiments reveal that hsa-mir-222 is a key factor enabling this process. Our results shed new light on melanoma plasticity, providing a potential target and guidance for therapeutic studies.
Identifiants
pubmed: 32784455
pii: jcm9082573
doi: 10.3390/jcm9082573
pmc: PMC7464186
pii:
doi:
Types de publication
Journal Article
Langues
eng
Subventions
Organisme : Associazione Italiana per la Ricerca sul Cancro
ID : 23141
Références
Nat Cell Biol. 2017 Jul;19(7):774-786
pubmed: 28581476
Cancers (Basel). 2016 May 17;8(5):
pubmed: 27196929
Nat Cell Biol. 2012 Oct;14(10):1099-1104
pubmed: 23000963
Cell. 2011 Jan 7;144(1):92-105
pubmed: 21215372
PLoS One. 2010 Dec 17;5(12):e14366
pubmed: 21179426
Phys Biol. 2016 Apr 29;13(3):036001
pubmed: 27125980
Semin Cancer Biol. 2018 Dec;53:42-47
pubmed: 30017637
PLoS One. 2010 Dec 22;5(12):e15183
pubmed: 21203549
J Theor Biol. 2010 Aug 7;265(3):329-35
pubmed: 20648969
Mol Med. 2015 Nov;21(1):676-687
pubmed: 26252186
Semin Cancer Biol. 2017 Jun;44:3-9
pubmed: 28254567
Nucleic Acids Res. 2014 Jan;42(Database issue):D68-73
pubmed: 24275495
Genome Biol. 2009;10(3):R25
pubmed: 19261174
Math Biosci. 2017 Jan;283:30-37
pubmed: 27832999
Neoplasia. 2008 Nov;10(11):1170-82
pubmed: 18953426
Genes Dev. 2008 Nov 15;22(22):3172-83
pubmed: 19056895
Nat Rev Cancer. 2003 May;3(5):362-74
pubmed: 12724734
Nucleic Acids Res. 2012 Jan;40(1):37-52
pubmed: 21911355
Dig Dis. 2013;31(3-4):293-8
pubmed: 24246977
Cancer Res. 2010 Jan 1;70(1):46-56
pubmed: 20048071
Proc Natl Acad Sci U S A. 2016 Oct 11;113(41):11408-11413
pubmed: 27681632
Science. 2014 Jun 27;344(6191):1492-6
pubmed: 24970081
Sci Rep. 2012;2:441
pubmed: 22679555
Curr Protoc Mol Biol. 2003 Aug;Chapter 9:Unit 9.1
pubmed: 18265332
Nat Commun. 2015 Sep 08;6:8198
pubmed: 26349061
Semin Cancer Biol. 2018 Dec;53:265-281
pubmed: 30317036
Bioinformatics. 2010 Jan 1;26(1):139-40
pubmed: 19910308
Cell. 2004 Sep 3;118(5):635-48
pubmed: 15339667
Sci Rep. 2015 Oct 23;5:15464
pubmed: 26494317
Integr Biol (Camb). 2015 Jan;7(1):14-23
pubmed: 25359461
Nat Cell Biol. 2017 Jun;19(6):666-676
pubmed: 28553937
Cell. 2011 Aug 19;146(4):633-44
pubmed: 21854987
F1000Res. 2018 Aug 24;7:1338
pubmed: 30254741
Proc Natl Acad Sci U S A. 2019 Jan 2;116(1):148-157
pubmed: 30587589
Cell Stem Cell. 2016 Feb 4;18(2):203-13
pubmed: 26831517
Curr Biol. 2017 Feb 6;27(3):392-400
pubmed: 28089517
Cancer Inform. 2015 Sep 07;14(Suppl 4):67-81
pubmed: 26396490
Proc Natl Acad Sci U S A. 2005 Oct 11;102(41):14677-82
pubmed: 16203973
PLoS Comput Biol. 2012 Jan;8(1):e1002316
pubmed: 22275856
J Transl Med. 2016 Feb 24;14:56
pubmed: 26912358