Clinical trials knowledge and attitudes of Vietnamese- and Anglo-Australian cancer patients: A cross-sectional study.
cancer
clinical trials
culturally and linguistically diverse (CALD)
migrants
psychology
Journal
Asia-Pacific journal of clinical oncology
ISSN: 1743-7563
Titre abrégé: Asia Pac J Clin Oncol
Pays: Australia
ID NLM: 101241430
Informations de publication
Date de publication:
Oct 2020
Oct 2020
Historique:
received:
19
02
2020
accepted:
13
05
2020
pubmed:
12
8
2020
medline:
28
10
2020
entrez:
12
8
2020
Statut:
ppublish
Résumé
Low participation in cancer clinical trials by culturally and linguistically diverse (CALD) patients limits access to cutting-edge treatments and generalizability of results. This is the first study exploring trials knowledge/attitudes and their association with trial participation in Vietnamese- and Anglo-Australian cancer patients. Eligible patients diagnosed with cancer in the past 10 years were invited to complete a self-report questionnaire comprising validated measures of: trials knowledge and attitudes, preferred information amount, preferred decision-making involvement, health literacy, and past and future (i.e. hypothetical) trial participation. Multivariable linear regression evaluated correlates of trials knowledge/attitudes. Multinomial logistic regression estimated the relationship between trials knowledge/attitudes and possible future trial participation. Vietnamese-Australian participants (n = 50) had more negative attitudes regarding trials than Anglo-Australians (n = 100; B = -9.28; 95% confidence interval [CI], -17.60 to -0.97; P = 0.029), but similar knowledge (B = -0.91; 95% CI, -2.27 to 0.44; P = 0.18). Future trial participation was associated with positive attitudes (odds ratio [OR] = 1.08; 95% CI, 1.04-1.12; P < 0.001) and greater knowledge (OR = 1.30; 95% CI, 1.04-1.62; P = 0.02), but not Vietnamese background (OR = 0.95; 95% CI, 0.27-3.32; P = 0.93). Despite poorer attitudes regarding trials in Vietnamese-Australians, Vietnamese background was not associated with less likely future trial participation, suggesting low trial participation by CALD patients may be more due to opportunity barriers. Improving knowledge and attitudes may increase trial participation generally.
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
e242-e251Informations de copyright
© 2020 John Wiley & Sons Australia, Ltd.
Références
Chow CJ, Habermann EB, Abraham A, et al. Does enrollment in cancer trials improve survival? J Am Coll Sur. 2013;216(4):774-781.
Dizon DS, Krilov L, Cohen E, et al. Clinical Cancer advances 2016: Annual report on progress against cancer from the American Society of Clinical Oncology. J Clin Oncol. 2016;34(9):987-1011.
Murthy VH, Krumholz HM, Gross CP. Participation in cancer clinical trials: Race-, sex-, and age-based disparities. JAMA. 2004;291(22):2720-2726.
Stewart JH, Bertoni AG, Staten JL, Levine EA, Gross CP. Participation in surgical oncology clinical trials: Gender-, race/ethnicity-, and age-based disparities. Ann Surg Oncol. 2007;14(12):3328-3334.
Unger JM, Vaidya R, Hershman DL, Minasian LM, Fleury ME. Systematic review and meta-analysis of the magnitude of structural, clinical, and physician and patient barriers to cancer clinical trial participation. J Nat Cancer Inst. 2019;111(3):245-255.
Hughson JA, Woodward-Kron R, Parker A, et al. A review of approaches to improve participation of culturally and linguistically diverse populations in clinical trials. Trials. 2016;17(1):263.
Duma N, Vera Aguilera J, Paludo J, et al. Representation of Minorities and women in oncology clinical trials: Review of the past 14 years. J Oncol Pract. 2017;14(1):e1-e10.
Smith AB, Agar M, Delaney G, et al. Lower trial participation by culturally and linguistically diverse (CALD) cancer patients is largely due to language barriers. Asia Pac J Clin Oncol. 2018;14(1):52-60.
FECCA. Cancer and Culturally and Linguistically Diverse Communities; 2010.
ECCV. ECCV Glossary of Terms 2012. Available from: eccv.org.au/library/file/document/ECCV_Glossary_of_Terms_23_October.docx.
Swanson GM, Bailar JC. Selection and description of cancer clinical trials participants: Science or happenstance?. Cancer. 2002;95(5):950-959.
Giuliano AR, Mokuau N, Hughes C, et al. Participation of minorities in cancer research: The influence of structural, cultural, and linguistic factors. Ann Epidemiol. 2000;10(8, Supplement 1):S22-S34.
Robinson JM, Trochim WMK. An examination of community members’, researchers’ and health professionals’ perceptions of barriers to minority participation in medical research: an application of concept mapping. Ethn Health. 2007;12(5):521-539.
Lee GE, Ow M, Lie D, Dent R. Barriers and facilitators for clinical trial participation among diverse Asian patients with breast cancer: A qualitative study. BMC Women's Health. 2016;16(1):43.
Kaplan CP, Nápoles AM, Narine S, et al. Knowledge and attitudes regarding clinical trials and willingness to participate among prostate cancer patients. Contemporary Clin. Trials. 2015;45(Part B):443-448.
Hussain-Gambles M. South Asian patients' views and experiences of clinical trial participation. Fam Pract. 2004;21(6):636-642.
Ford JG, Howerton MW, Lai GY, et al. Barriers to recruiting underrepresented populations to cancer clinical trials: A systematic review. Cancer. 2008;112(2):228-242.
Meropol NJ, Wong Y-N, Albrecht T, et al. Randomized trial of a web-based intervention to address barriers to clinical trials. J Clin Oncol. 2016;34(5):469.
Kim ES, Bruinooge SS, Roberts S, et al. Broadening eligibility criteria to make clinical trials more representative: American Society of Clinical Oncology and Friends of Cancer Research Joint Research Statement. J Clin Oncol. 2017;35(33):3737-3744.
Ma GX, Fleisher L. Awareness of cancer information among Asian Americans. J Comm Health. 2003;28(2):115-130.
Hyatt A, Lipson-Smith R, Schofield P, et al. Communication challenges experienced by migrants with cancer: A comparison of migrant and English-speaking Australian-born cancer patients. Health Expect. 2017;20(5):886-895.
Brown DR, Fouad MN, Basen-Engquist K, Tortolero-Luna G. Recruitment and retention of minority women in cancer screening, prevention, and treatment trials. Ann Epidemiol. 2000;10(8, Supplement 1):S13-S21.
Rivers D, August EM, Sehovic I, Lee Green B, Quinn GP. A systematic review of the factors influencing African Americans' participation in cancer clinical trials. Contemporary Clinical Trials. 2013;35(2):13-32.
SWSLHD. SWSLHD Cancer Plan 2018-2023: Leading care, healthier communities. Liverpool, NSW: SWSLHD; 2017.
SWSLHD. Health Profile of Local Communities. In: Health, editor. 2014.
Lim BT, Butow P, Sze ML, et al. Impact of migrancy on cancer clinical trial participation: Factors associated with approach and consent in Australian-born versus migrant groups. Asia Pac J Clin Oncol. 2020;16:115-122.
Cassileth BR, Zupkis RV, Sutton-Smith K, March V. Information and participation preferences among cancer patients. Ann Intern Med. 1980;92(6):832-836.
Degner LF, Kristjanson LJ, Bowman D, Sloan JA, Carriere K, O'neil J, et al. Information needs and decisional preferences in women with breast cancer. JAMA. 1997;277(18):1485-1492.
Chew LD, Griffin JM, Partin MR, et al. Validation of screening questions for limited health literacy in a large VA outpatient population. J Gen Inter Med. 2008;23(5):561-566.
Al-Tannir MA, El-Bakri N, Abu- Shaheen AK. Knowledge, attitudes and perceptions of saudis towards participating in clinical trials. PLoS One. 2016;11(2):e0143893.
Langford A, Resnicow K, An L. Clinical trial awareness among racial/ethnic minorities in HINTS 2007: Sociodemographic, attitudinal, and knowledge correlates. J Health Commun. 2010;15(Suppl. 3):92-101.
George S, Duran N, Norris K. A systematic review of barriers and facilitators to minority research participation among African Americans, Latinos, Asian Americans, and Pacific Islanders. Am J Public Health. 2014;104(2):e16-e31.
Tu SP, Chen H, Chen A, Lim J, May S, Drescher C. Clinical trials: Understanding and perceptions of female Chinese-American cancer patients. Cancer. 2005;104(12 SUPPL):2999-3005.
Phillipson L, Larsen-Truong K, Jones S, Pitts L, Improving cancer outcomes among culturally and linguistically diverse communities: A rapid review of the literature. Australia: The Sax Institute.
Hussain-Gambles M, Leese B, Atkin K, Brown J, Mason S, Tovey P. Involving South Asian patients in clinical trials. Health Technol Assess. 2004;8(42):iii97.
Kaur R, Meiser B, Zilliacus E, et al. Evaluation of an online communication skills training programme for oncology nurses working with patients from minority backgrounds. Support Care Cancer. 2019;27(5):1951-1960.
Ford JG, Howerton MW, Bolen S, et al. Knowledge and access to information on recruitment of underrepresented populations to cancer clinical trials. Evid Rep Technol Assess (Summ). 2005(122):1-11.
Albrecht TL, Eggly SS, Gleason MEJ, et al. Influence of clinical communication on patients’ decision making on participation in clinical trials. J Clin Oncol. 2008;26(16). 10.1200/JCO.2007.14.8114.
Yeh JC, Cheng MJ, Chung CH, Smith TJ. Using a question prompt list as a communication aid in advanced cancer care. J Oncol Pract. 2014;10(3):e137-e141.
Natale-Pereira A, Enard KR, Nevarez L, Jones LA. The role of patient navigators in eliminating health disparities. Cancer. 2011;117(15):3541-3550.
Ghebre RG, Jones LA, Wenzel JA, Martin MY, Durant RW, Ford JG. State-of-the-science of patient navigation as a strategy for enhancing minority clinical trial accrual. Cancer. 2014;120(Suppl 7):1122-1130.
Uveges MK, Lansey DG, Mbah O, Gray T, Sherden L, Wenzel J. Patient navigation and clinical trial participation: A randomized controlled trial design. Contemp Clin Trials Commu. 2018;12:98-102.
Ellis PM, Butow PN, Tattersall MH, Dunn SM, Houssami N. Randomized clinical trials in oncology: Understanding and attitudes predict willingness to participate. J Clin Oncol. 2001;19(15):3554-3561.
Nicholson LM, Schwirian PM, Groner JA. Recruitment and retention strategies in clinical studies with low-income and minority populations: Progress from 2004-2014. Contemp Clin Trials. 2015;45:34-40.
Stanaway F, Cumming RG, Blyth F. Exclusions from clinical trials in Australia based on proficiency in English. Med J Aust. 2017;207(1):36.
Wendler D, Kington R, Madans J, et al. Are racial and ethnic minorities less willing to participate in health research?. PLoS Med. 2006;3(2):201-210.
Sniehotta FF, Scholz U, Schwarzer R. Bridging the intention-behaviour gap: Planning, self-efficacy, and action control in the adoption and maintenance of physical exercise. Psychology & Health. 2005;20(2):143-160.
Butow PN, Bell ML, Aldridge LJ, et al. Unmet needs in immigrant cancer survivors: A cross-sectional population-based study. Support Care Cancer. 2013;21(9):2509-2520.
Shavers VL, Lynch CF, Burmeister LF. Racial differences in factors that influence the willingness to participate in medical research studies. Ann Epidemiol. 2002;12(4):248-256.