In vitro and in vivo evaluation of cubosomal nanoparticles as an ocular delivery system for fluconazole in treatment of keratomycosis.

Animals Antifungal Agents / administration & dosage Cornea Drug Delivery Systems Eye Infections, Fungal / drug therapy Fluconazole / administration & dosage Keratitis / drug therapy Nanoparticles Particle Size Rabbits Rats
Corneal permeation Cubosomes Fluconazole Keratomycosis Ocular delivery

Journal

Drug delivery and translational research
ISSN: 2190-3948
Titre abrégé: Drug Deliv Transl Res
Pays: United States
ID NLM: 101540061

Informations de publication

Date de publication:
12 2020
Historique:
pubmed: 12 8 2020
medline: 3 11 2021
entrez: 12 8 2020
Statut: ppublish

Résumé

The objective of the present study was to enhance ocular antifungal activity of fluconazole (FCZ) in treatment of keratomycosis through incorporation into cubosomal nanoparticles. FCZ-loaded cubosomal dispersions were prepared by emulsification method according to 2

Identifiants

DOI: 10.1007/s13346-020-00830-4 PMID: 32779112
pubmed: 32779112
doi: 10.1007/s13346-020-00830-4
pii: 10.1007/s13346-020-00830-4
doi:

Substances chimiques

Antifungal Agents 0
Fluconazole 8VZV102JFY

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

1841-1852

Auteurs

Mohamed Nasr (M)

Department of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy, Helwan University, Cairo, 11790, Egypt. m2nasr@yahoo.com.
Department of Pharmaceutics, Faculty of Pharmacy, Delta University for Science and Technology, Gamasa, Egypt. m2nasr@yahoo.com.
ORCID: 0000-0001-6382-3221

Mohamed Teiama (M)

Department of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy, Helwan University, Cairo, 11790, Egypt.

Aliaa Ismail (A)

Department of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy, Helwan University, Cairo, 11790, Egypt.

Asmaa Ebada (A)

Department of Microbiology, Faculty of Pharmacy, Delta University for Science and Technology, Gamasa, Egypt.

Sameh Saber (S)

Department of Pharmacology, Faculty of Pharmacy, Delta University for Science and Technology, Gamasa, Egypt.

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Classifications MeSH

Recherchemedicale.com › Eucaryotes › Animaux › In vitro and in vivo evaluation of cubosomal...
Recherchemedicale.com › Actions chimiques et utilisations › Actions pharmacologiques › Utilisations thérapeutiques › Anti-infectieux › Antifongiques › In vitro and in vivo evaluation of cubosomal...
Recherchemedicale.com › Organes des sens › Oeil › Pôle antérieur du bulbe oculaire › Cornée › In vitro and in vivo evaluation of cubosomal...
Recherchemedicale.com › Thérapeutique › Traitement médicamenteux › Systèmes de délivrance de médicaments › In vitro and in vivo evaluation of cubosomal...
Recherchemedicale.com › Maladies de l'oeil › Infections de l'oeil › Mycoses oculaires › In vitro and in vivo evaluation of cubosomal...
Recherchemedicale.com › Composés hétérocycliques › Composés hétéromonocycliques › Azoles › Triazoles › Fluconazole › In vitro and in vivo evaluation of cubosomal...
Recherchemedicale.com › Maladies de l'oeil › Maladies de la cornée › Kératite › In vitro and in vivo evaluation of cubosomal...
Recherchemedicale.com › Technologie, industrie et agriculture › Produits manufacturés › Nanostructures › Nanoparticules › In vitro and in vivo evaluation of cubosomal...
Recherchemedicale.com › Phénomènes chimiques › Taille de particule › In vitro and in vivo evaluation of cubosomal...
Recherchemedicale.com › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Lagomorpha › Lapins › In vitro and in vivo evaluation of cubosomal...
Recherchemedicale.com › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Rats › In vitro and in vivo evaluation of cubosomal...