The Mechanism of Ferroptosis and Applications in Tumor Treatment.
cancer
drug
drug resistance
ferroptosis
mechanism
Journal
Frontiers in pharmacology
ISSN: 1663-9812
Titre abrégé: Front Pharmacol
Pays: Switzerland
ID NLM: 101548923
Informations de publication
Date de publication:
2020
2020
Historique:
received:
16
04
2020
accepted:
30
06
2020
entrez:
11
8
2020
pubmed:
11
8
2020
medline:
11
8
2020
Statut:
epublish
Résumé
Iron-dependent ferroptosis is a new form of cell death in recent years, which is driven by lipid peroxidation. The lethal lipid accumulation caused by glutathione depletion or inactivation of glutathione peroxidase 4 (GPX4) is characteristic of the ferroptosis process. In recent years, with the in-depth study of ferroptosis, various types of diseases have been reported to be related to ferroptosis. In other words, ferroptosis, which has attracted widespread attention in the fields of biochemistry, oncology, and especially materials science, can undoubtedly provide a new way for patients. This review introduces the relevant mechanisms of ferroptosis, the relationship between ferroptosis and various cancers, as well as the application of ferroptosis in tumor treatment. We also sorted out the genes and drugs that regulate ferroptosis. Moreover, small molecule compound-induced ferroptosis has a strong inhibitory effect on tumor growth in a drug-resistant environment, which can enhance the sensitivity of chemotherapeutic drugs, suggesting that ferroptosis is very important in the treatment of tumor drug resistance, but the details are still unclear. How to use ferroptosis to fight cancer, and how to prevent drug-resistant tumor cells have become the focus and direction of research. At the end of the article, some existing problems related to ferroptosis are summarized for future research.
Identifiants
pubmed: 32774303
doi: 10.3389/fphar.2020.01061
pmc: PMC7388725
doi:
Types de publication
Journal Article
Review
Langues
eng
Pagination
1061Informations de copyright
Copyright © 2020 Lin, Ping, Wen and Wu.
Références
Cancer Metab. 2015 Oct 20;3:11
pubmed: 26500770
Oncogene. 2015 Nov 5;34(45):5617-25
pubmed: 25728673
Proc Natl Acad Sci U S A. 2014 Nov 25;111(47):16836-41
pubmed: 25385600
Oncotarget. 2016 Nov 8;7(45):74132-74151
pubmed: 27708226
Neoplasia. 2017 Dec;19(12):1022-1032
pubmed: 29144989
Hepatology. 2016 Jan;63(1):173-84
pubmed: 26403645
Mol Cell Oncol. 2015 May 26;2(4):e1054549
pubmed: 27308510
ACS Cent Sci. 2016 Sep 28;2(9):653-659
pubmed: 27725964
Front Neurosci. 2018 Jul 10;12:466
pubmed: 30042655
Biomed Pharmacother. 2020 Jun;126:110092
pubmed: 32203890
Cell Death Dis. 2016 Jul 21;7:e2307
pubmed: 27441659
Onco Targets Ther. 2019 Dec 19;12:11241-11254
pubmed: 31908490
Nat Chem Biol. 2017 Jan;13(1):91-98
pubmed: 27842070
Oxid Med Cell Longev. 2019 Jun 10;2019:3150145
pubmed: 31281572
PLoS One. 2018 Aug 15;13(8):e0201369
pubmed: 30110365
Sci Rep. 2018 Jan 17;8(1):968
pubmed: 29343855
Int J Cancer. 2013 Oct 1;133(7):1732-42
pubmed: 23505071
Cell Res. 2016 Sep;26(9):1021-32
pubmed: 27514700
Genes Dev. 2016 Apr 15;30(8):918-30
pubmed: 27034505
Int J Nanomedicine. 2013;8:1517-24
pubmed: 23620667
Oncol Rep. 2019 Aug;42(2):826-838
pubmed: 31173262
Oncotarget. 2016 Jun 7;7(23):33529-41
pubmed: 27244881
Int J Mol Med. 2018 May;41(5):3051-3062
pubmed: 29436589
Redox Biol. 2017 Apr;11:254-262
pubmed: 28012440
Cell. 2011 Nov 11;147(4):742-58
pubmed: 22078876
Oncotarget. 2016 Jun 14;7(24):36021-36033
pubmed: 27074570
Cell Death Differ. 2016 Feb;23(2):270-8
pubmed: 26184909
Anticancer Res. 2014 Nov;34(11):6417-22
pubmed: 25368241
Free Radic Biol Med. 1999 Nov;27(9-10):922-35
pubmed: 10569625
Small GTPases. 2017 Jan 2;8(1):38-42
pubmed: 27215184
Cell Cycle. 2015;14(18):2881-5
pubmed: 26218928
Nature. 2014 May 1;509(7498):105-9
pubmed: 24695223
Mol Carcinog. 2017 Jan;56(1):75-93
pubmed: 26878598
PLoS Biol. 2018 May 24;16(5):e2006203
pubmed: 29795546
Oncogene. 2017 Jul 20;36(29):4089-4099
pubmed: 28319068
Biochem Pharmacol. 2002 Sep;64(5-6):1019-26
pubmed: 12213601
Biomed Pharmacother. 2020 Jun 9;129:110282
pubmed: 32531676
Cancer Lett. 2015 Nov 1;368(1):88-96
pubmed: 26254540
Cancer Cell Int. 2020 Jan 13;20:18
pubmed: 31956296
Front Physiol. 2019 Feb 26;10:139
pubmed: 30863316
Cancer Biol Ther. 2015;16(10):1548-56
pubmed: 26176175
CA Cancer J Clin. 2019 Jan;69(1):7-34
pubmed: 30620402
Oncotarget. 2017 Dec 9;8(70):114588-114602
pubmed: 29383104
Nature. 2019 Apr;568(7753):511-516
pubmed: 30971826
Cell. 2014 Jan 16;156(1-2):317-331
pubmed: 24439385
Cancer Res Treat. 2018 Apr;50(2):445-460
pubmed: 28494534
Kaohsiung J Med Sci. 2020 Jul;36(7):515-522
pubmed: 32237034
Nature. 2017 Nov 9;551(7679):247-250
pubmed: 29088702
Cancer Cell. 2015 Feb 9;27(2):211-22
pubmed: 25620030
Biochem Biophys Res Commun. 2016 Nov 18;480(3):443-449
pubmed: 27773819
Chem Biol. 2008 Mar;15(3):234-45
pubmed: 18355723
J Biol Chem. 2000 Sep 8;275(36):28110-9
pubmed: 10821829
ACS Chem Biol. 2015 Jul 17;10(7):1604-9
pubmed: 25965523
Biochim Biophys Acta. 2013 May;1830(5):3289-303
pubmed: 23201771
Biochem Biophys Res Commun. 2016 May 13;473(4):775-780
pubmed: 27037021
Mol Cell. 2015 Jul 16;59(2):298-308
pubmed: 26166707
Cell Death Differ. 2018 Aug;25(8):1457-1472
pubmed: 29348676
Proc Natl Acad Sci U S A. 2016 Aug 23;113(34):E4966-75
pubmed: 27506793
Leukemia. 2001 Oct;15(10):1633-40
pubmed: 11587223
Nat Commun. 2020 Jan 23;11(1):433
pubmed: 31974380
Clin Cancer Res. 2013 Feb 15;19(4):845-54
pubmed: 23344263
Hepatology. 2016 Aug;64(2):488-500
pubmed: 27015352
Oncotarget. 2015 Sep 15;6(27):24393-403
pubmed: 26405158
Semin Cancer Biol. 2019 Aug;57:19-26
pubmed: 30273655
Cancer Lett. 2016 Oct 10;381(1):96-103
pubmed: 27477897
Arch Biochem Biophys. 1978 Sep;190(1):27-38
pubmed: 213032
Nat Chem Biol. 2018 May;14(5):507-515
pubmed: 29610484
Biochem Biophys Res Commun. 2016 Sep 16;478(2):838-44
pubmed: 27510639
Oncotarget. 2018 Sep 18;9(73):33832-33843
pubmed: 30333913
Chem Rev. 1950 Feb;46(1):155-69
pubmed: 24537520
Cell Death Dis. 2018 Jul 9;9(7):753
pubmed: 29988039
Front Oncol. 2019 Dec 19;9:1398
pubmed: 31921655
Cell Death Dis. 2018 Aug 6;9(8):841
pubmed: 30082680
Theranostics. 2020 Apr 6;10(11):5107-5119
pubmed: 32308771
Elife. 2014 May 20;3:e02523
pubmed: 24844246
Cell. 2017 Oct 5;171(2):273-285
pubmed: 28985560
Redox Biol. 2015;4:193-9
pubmed: 25598486
Anat Rec (Hoboken). 2020 Jan 21;:
pubmed: 31961485
Nat Chem Biol. 2017 Jan;13(1):81-90
pubmed: 27842066
Nature. 2017 Jul 27;547(7664):453-457
pubmed: 28678785
Cell Rep. 2017 Aug 15;20(7):1692-1704
pubmed: 28813679
Int J Oncol. 2018 Mar;52(3):1011-1022
pubmed: 29393418
Oncol Rep. 2015 Mar;33(3):1465-74
pubmed: 25585997
Oncoscience. 2015 May 02;2(5):517-32
pubmed: 26097885
Cell Death Differ. 2010 Jun;17(6):922-30
pubmed: 20010783
Nature. 2019 Nov;575(7784):688-692
pubmed: 31634900
Adv Exp Med Biol. 2019;1152:311-334
pubmed: 31456192
Cancer Sci. 2019 Oct;110(10):3173-3182
pubmed: 31464035
Nano Lett. 2017 Feb 8;17(2):928-937
pubmed: 28139118
Can Dis Wkly Rep. 1990 Sep;16 Suppl 1E:47-57; discussion 57-8
pubmed: 1966279
Proc Natl Acad Sci U S A. 2010 Apr 20;107(16):7455-60
pubmed: 20378837
Nat Chem Biol. 2016 Jul;12(7):497-503
pubmed: 27159577
Mol Cell. 2019 Jan 17;73(2):354-363.e3
pubmed: 30581146
Chem Phys Lipids. 2014 Jul;181:1-33
pubmed: 24704586
Nature. 2015 Apr 2;520(7545):57-62
pubmed: 25799988
Oncotarget. 2016 Mar 15;7(11):11756-69
pubmed: 26930718
Free Radic Biol Med. 2019 Feb 1;131:356-369
pubmed: 30557609
Cell Chem Biol. 2020 Apr 16;27(4):420-435
pubmed: 32160513
Am J Cancer Res. 2019 Apr 01;9(4):730-739
pubmed: 31105999
Sci Rep. 2018 Mar 26;8(1):5155
pubmed: 29581451
Cancer Lett. 2015 Jan 28;356(2 Pt B):971-7
pubmed: 25444922
J Lipid Res. 2011 Apr;52(4):782-93
pubmed: 21242590
Biochim Biophys Acta. 2000 Aug 24;1487(1):61-73
pubmed: 10962288
Biochim Biophys Acta Gen Subj. 2019 Sep;1863(9):1398-1409
pubmed: 31229492
Autophagy. 2015;11(8):1198-208
pubmed: 26054373
Cell Death Differ. 2018 Mar;25(3):486-541
pubmed: 29362479
Nature. 2007 Jun 14;447(7146):864-8
pubmed: 17568748
Nanoscale. 2018 Sep 27;10(37):17858-17864
pubmed: 30221289
Biochem Biophys Res Commun. 2018 Sep 10;503(3):1550-1556
pubmed: 30031610
Autophagy. 2016 Aug 2;12(8):1425-8
pubmed: 27245739
Cell Metab. 2008 Sep;8(3):237-48
pubmed: 18762024
Biochim Biophys Acta. 2015 Apr;1851(4):308-30
pubmed: 25316652
Lancet. 2005 Aug 27-Sep 2;366(9487):717-25
pubmed: 16125588
Nat Rev Drug Discov. 2016 May;15(5):311-25
pubmed: 26822829
Cell. 2012 May 25;149(5):1060-72
pubmed: 22632970
PLoS One. 2017 Aug 21;12(8):e0182921
pubmed: 28827805
PLoS One. 2017 Sep 5;12(9):e0183702
pubmed: 28873095
J Mol Diagn. 2005 Oct;7(4):437-43
pubmed: 16237213