Paclitaxel and quercetin co-loaded functional mesoporous silica nanoparticles overcoming multidrug resistance in breast cancer.
Chemotherapy
Mesoporous silica nanoparticles
Multidrug resistance
P-glycoprotein
Targeting
Journal
Colloids and surfaces. B, Biointerfaces
ISSN: 1873-4367
Titre abrégé: Colloids Surf B Biointerfaces
Pays: Netherlands
ID NLM: 9315133
Informations de publication
Date de publication:
Dec 2020
Dec 2020
Historique:
received:
12
02
2020
revised:
16
07
2020
accepted:
26
07
2020
pubmed:
11
8
2020
medline:
22
6
2021
entrez:
11
8
2020
Statut:
ppublish
Résumé
Multidrug resistance (MDR) in tumor has long been considered a major factor in the failure of tumor chemotherapy. P-glycoprotein (P-gp)-mediated drug efflux plays a significant role in the MDR of tumor. Herein, paclitaxel (PTX) and P-gp inhibitor quercetin (QC) co-loaded and chondroitin sulfate (ChS)-coated mesoporous silica nanoparticles (MSNs) (MSNs-ChS@PQ) were developed to reverse MDR in breast cancer and improve chemotherapy efficacy. The dual drug-loaded nanoparticles (NPs) showed a nanoscale size of ∼ 227.2 nm and redox-responsive drug release property. In vitro cell experiments showed that NPs exhibited CD44 receptor-mediated active targeting in MCF-7/ADR cells. The dual drug-loaded NPs had lower IC
Identifiants
pubmed: 32771817
pii: S0927-7765(20)30640-8
doi: 10.1016/j.colsurfb.2020.111284
pii:
doi:
Substances chimiques
Silicon Dioxide
7631-86-9
Quercetin
9IKM0I5T1E
Paclitaxel
P88XT4IS4D
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
111284Informations de copyright
Copyright © 2020 Elsevier B.V. All rights reserved.