A Case of Kawasaki Disease Complicated With Cerebral Salt-Wasting Syndrome.
Kawasaki disease
cerebral salt-wasting syndrome (CSWS)
fractional excretion of uric acid (FEUA)
hyponatremia
syndrome of inappropriate antidiuretic hormone secretion (SIADH)
Journal
Frontiers in pediatrics
ISSN: 2296-2360
Titre abrégé: Front Pediatr
Pays: Switzerland
ID NLM: 101615492
Informations de publication
Date de publication:
2020
2020
Historique:
received:
29
03
2020
accepted:
19
05
2020
entrez:
9
8
2020
pubmed:
9
8
2020
medline:
9
8
2020
Statut:
epublish
Résumé
We report the case of a 3-years-old boy who developed severe hyponatremia and unconsciousness during an episode of Kawasaki disease (KD). He was diagnosed with cerebral salt-wasting syndrome (CSWS), which has not previously been reported as a complication of KD. He was diagnosed with KD with fever and four clinical signs and received intravenous immunoglobulin (IVIG) on the day after onset. Hyponatremia had been observed, and it worsened after IVIG. At first, syndrome of inappropriate antidiuretic hormone secretion (SIADH) was suspected, but his hyponatremia did not improve by restriction of water intake. The patient's consciousness level decreased along with the worsening hyponatremia. Electroencephalography revealed abnormal electrical discharge concordant with acute encephalopathy. Laboratory data showed hypouricemia with high fractional excretion of uric acid (FEUA), in addition to a negative balance of both Na and water. We diagnosed KD complicated with CSWS. The patient improved promptly with appropriate Na supplementation and water correction.
Identifiants
pubmed: 32766177
doi: 10.3389/fped.2020.00325
pmc: PMC7380064
doi:
Types de publication
Case Reports
Langues
eng
Pagination
325Informations de copyright
Copyright © 2020 Oshima, Fukuhara, Noto, Noguchi, Murabayashi, Ayusawa and Morioka.
Références
Nephrol Dial Transplant. 2000 Feb;15(2):262-8
pubmed: 10648680
Brain Dev. 2012 Aug;34(7):605-8
pubmed: 22019463
Pediatr Nephrol. 2012 May;27(5):733-9
pubmed: 22237777
Medicine (Baltimore). 2016 Sep;95(36):e4393
pubmed: 27603336
J Neurol Sci. 2012 Apr 15;315(1-2):167-9
pubmed: 22129937
Pediatr Cardiol. 2011 Jun;32(5):696-9
pubmed: 21380714
J Clin Endocrinol Metab. 2008 Aug;93(8):2991-7
pubmed: 18477658
Lancet. 2012 Apr 28;379(9826):1613-20
pubmed: 22405251
Am J Hematol. 2001 May;67(1):59
pubmed: 11279662
Eur J Paediatr Neurol. 2015 May;19(3):377-82
pubmed: 25707871
Korean Circ J. 2010 Oct;40(10):507-13
pubmed: 21088754
Curr Drug Saf. 2019;14(1):3-13
pubmed: 30332974
Front Med (Lausanne). 2018 Nov 30;5:319
pubmed: 30560127
Physiol Meas. 1994 Aug;15(3):251-60
pubmed: 7994203
J Clin Med. 2014 Dec 08;3(4):1373-85
pubmed: 26237607