Imaging Alzheimer's genetic risk using diffusion MRI: A systematic review.
Alzheimer's Disease
Apolipoproteins E
Diffusion Tensor Imaging
Magnetic Resonance Imaging
Multifactorial Inheritance
Presenilin-1
Presenilin-2
Journal
NeuroImage. Clinical
ISSN: 2213-1582
Titre abrégé: Neuroimage Clin
Pays: Netherlands
ID NLM: 101597070
Informations de publication
Date de publication:
2020
2020
Historique:
received:
23
12
2019
revised:
20
06
2020
accepted:
20
07
2020
pubmed:
8
8
2020
medline:
29
6
2021
entrez:
8
8
2020
Statut:
ppublish
Résumé
Diffusion magnetic resonance imaging (dMRI) is an imaging technique which probes the random motion of water molecules in tissues and has been widely applied to investigate changes in white matter microstructure in Alzheimer's Disease. This paper aims to systematically review studies that examined the effect of Alzheimer's risk genes on white matter microstructure. We assimilated findings from 37 studies and reviewed their diffusion pre-processing and analysis methods. Most studies estimate the diffusion tensor (DT) and compare derived quantitative measures such as fractional anisotropy and mean diffusivity between groups. Those with increased AD genetic risk are associated with reduced anisotropy and increased diffusivity across the brain, most notably the temporal and frontal lobes, cingulum and corpus callosum. Structural abnormalities are most evident amongst those with established Alzheimer's Disease. Recent studies employ signal representations and analysis frameworks beyond DT MRI but show that dMRI overall lacks specificity to disease pathology. However, as the field advances, these techniques may prove useful in pre-symptomatic diagnosis or staging of Alzheimer's disease.
Identifiants
pubmed: 32758801
pii: S2213-1582(20)30196-0
doi: 10.1016/j.nicl.2020.102359
pmc: PMC7399253
pii:
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Systematic Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
102359Subventions
Organisme : Wellcome Trust
ID : 215944/Z/19/Z
Pays : United Kingdom
Organisme : Wellcome Trust
ID : 104943/Z/14/Z
Pays : United Kingdom
Informations de copyright
Copyright © 2020 The Authors. Published by Elsevier Inc. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
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