ADPKD
collecting ducts
renal development
stem cell
Journal
Journal of the American Society of Nephrology : JASN
ISSN: 1533-3450
Titre abrégé: J Am Soc Nephrol
Pays: United States
ID NLM: 9013836
Informations de publication
Date de publication:
10 2020
10 2020
Historique:
received:
30
03
2020
accepted:
15
06
2020
pubmed:
5
8
2020
medline:
6
3
2021
entrez:
5
8
2020
Statut:
ppublish
Résumé
Autosomal dominant polycystic kidney disease (ADPKD) is the most common hereditary kidney disease leading to renal failure, wherein multiple cysts form in renal tubules and collecting ducts derived from distinct precursors: the nephron progenitor and ureteric bud (UB), respectively. Recent progress in induced pluripotent stem cell (iPSC) biology has enabled cyst formation in nephron progenitor-derived human kidney organoids in which CRISPR-Cas9 technology deleted Cysts formed in UB organoids with homozygous Cysts form in
Sections du résumé
BACKGROUND
Autosomal dominant polycystic kidney disease (ADPKD) is the most common hereditary kidney disease leading to renal failure, wherein multiple cysts form in renal tubules and collecting ducts derived from distinct precursors: the nephron progenitor and ureteric bud (UB), respectively. Recent progress in induced pluripotent stem cell (iPSC) biology has enabled cyst formation in nephron progenitor-derived human kidney organoids in which
METHODS
CRISPR-Cas9 technology deleted
RESULTS
Cysts formed in UB organoids with homozygous
CONCLUSIONS
Cysts form in
Identifiants
pubmed: 32747355
pii: ASN.2020030378
doi: 10.1681/ASN.2020030378
pmc: PMC7609014
doi:
Substances chimiques
TRPP Cation Channels
0
polycystic kidney disease 1 protein
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
2355-2371Informations de copyright
Copyright © 2020 by the American Society of Nephrology.
Références
Nat Biotechnol. 2015 Nov;33(11):1193-200
pubmed: 26458176
Annu Rev Physiol. 2009;71:83-113
pubmed: 19572811
EMBO Rep. 2006 Oct;7(10):1006-12
pubmed: 16936637
Genome Med. 2019 Jan 23;11(1):3
pubmed: 30674341
J Am Soc Nephrol. 2016 Apr;27(4):1124-34
pubmed: 26289612
Nature. 2000 Dec 21-28;408(6815):990-4
pubmed: 11140688
Nat Genet. 1999 Feb;21(2):160-1
pubmed: 9988265
Nat Mater. 2017 Nov;16(11):1112-1119
pubmed: 28967916
Am J Physiol. 1996 Jul;271(1 Pt 2):F169-83
pubmed: 8760258
Lancet. 2007 Apr 14;369(9569):1287-1301
pubmed: 17434405
Exp Anim. 2014;63(1):79-84
pubmed: 24521866
Science. 2018 Sep 7;361(6406):
pubmed: 30093605
Hum Mol Genet. 2001 Oct 1;10(21):2385-96
pubmed: 11689485
Methods. 2016 May 15;101:27-35
pubmed: 26525194
Am J Kidney Dis. 2013 Mar;61(3):420-9
pubmed: 23089511
Nucleic Acids Res. 1997 Sep 15;25(18):3745-6
pubmed: 9278500
Biochem Biophys Res Commun. 2018 Jan 1;495(1):954-961
pubmed: 29158085
Methods Mol Biol. 2017;1597:179-193
pubmed: 28361318
Cell Stem Cell. 2017 Dec 7;21(6):730-746.e6
pubmed: 29129523
Anesthesiology. 2006 Sep;105(3):599-612; quiz 639-40
pubmed: 16931995
Nat Genet. 2003 Feb;33(2):129-37
pubmed: 12514735
Cell Stem Cell. 2014 Jan 2;14(1):53-67
pubmed: 24332837
Nephrol Dial Transplant. 2010 Apr;25(4):1067-78
pubmed: 19945952
Cell Stem Cell. 2018 Dec 6;23(6):869-881.e8
pubmed: 30449713
Genome Biol. 2015 Jun 16;16:126
pubmed: 26076956
Am J Kidney Dis. 2010 Jul;56(1):50-6
pubmed: 20452711
Nature. 2015 Oct 22;526(7574):564-8
pubmed: 26444236
Kidney Int. 2004 Sep;66(3):964-73
pubmed: 15327388
J Lab Clin Med. 2003 Feb;141(2):91-101
pubmed: 12577044
J Am Soc Nephrol. 2016 Jun;27(6):1778-91
pubmed: 26586691
Biochem Biophys Res Commun. 2001 Mar 23;282(1):341-50
pubmed: 11264013
Nature. 2016 Mar 31;531(7596):656-60
pubmed: 27007841
J Am Soc Nephrol. 2000 May;11(5):814-827
pubmed: 10770959
J Clin Invest. 2004 Nov;114(10):1433-43
pubmed: 15545994
Hum Mol Genet. 1996 Apr;5(4):539-42
pubmed: 8845849
Nephrol Dial Transplant. 1997 Oct;12(10):2069-74
pubmed: 9351067
BMC Evol Biol. 2008 Sep 26;8:263
pubmed: 18822117
Nat Genet. 2009 Jul;41(7):793-9
pubmed: 19543268
J Biol Chem. 1996 Apr 12;271(15):8772-8
pubmed: 8621513
Am J Hum Genet. 1997 Nov;61(5):1044-52
pubmed: 9345095
Trends Mol Med. 2001 Apr;7(4):151-6
pubmed: 11286938
Pharmacotherapy. 2014 Jun;34(6):605-16
pubmed: 24706579
Sci Rep. 2018 Apr 9;8(1):5704
pubmed: 29632324
Nat Commun. 2019 Dec 11;10(1):5517
pubmed: 31822676
Nat Rev Nephrol. 2010 Sep;6(9):530-8
pubmed: 20625375
Nat Methods. 2019 Mar;16(3):255-262
pubmed: 30742039
Nat Genet. 1997 Oct;17(2):179-81
pubmed: 9326937
Nat Cell Biol. 2016 Jul;18(7):752-764
pubmed: 27214281
Cell. 2007 Nov 30;131(5):861-72
pubmed: 18035408
Science. 2012 Aug 17;337(6096):816-21
pubmed: 22745249
J Am Soc Nephrol. 2019 Feb;30(2):304-321
pubmed: 30635375
Sci Rep. 2016 Jul 15;6:30013
pubmed: 27418197
Clin J Am Soc Nephrol. 2010 May;5(5):889-96
pubmed: 20360307
Pediatr Nephrol. 2007 Mar;22(3):380-8
pubmed: 17124604
Dev Cell. 2019 Nov 4;51(3):399-413.e7
pubmed: 31689386
J Am Soc Nephrol. 2016 Sep;27(9):2872-84
pubmed: 26823553
Dis Model Mech. 2010 May-Jun;3(5-6):354-65
pubmed: 20335443
Nat Methods. 2012 Jul;9(7):671-5
pubmed: 22930834
Nat Commun. 2015 Oct 23;6:8715
pubmed: 26493500
Cell Stem Cell. 2016 Oct 6;19(4):516-529
pubmed: 27570066
Cell Stem Cell. 2018 Jun 01;22(6):929-940.e4
pubmed: 29779890