Evaluation of the bone morphology around four types of porous metal implants placed in distal femur of ovariectomized rats.
Animals
Bone Remodeling
/ physiology
Bone and Bones
/ pathology
Female
Femur
/ diagnostic imaging
Metals
Models, Animal
Osseointegration
/ physiology
Osteocytes
/ cytology
Osteogenesis
/ physiology
Osteoporosis
/ pathology
Ovariectomy
/ adverse effects
Porosity
Prostheses and Implants
/ adverse effects
Rats
Tantalum
Titanium
Animal model
Bone remodeling
Histology
Osteoporosis
Tantalum
Titanium
Journal
Journal of orthopaedic surgery and research
ISSN: 1749-799X
Titre abrégé: J Orthop Surg Res
Pays: England
ID NLM: 101265112
Informations de publication
Date de publication:
03 Aug 2020
03 Aug 2020
Historique:
received:
03
06
2020
accepted:
28
07
2020
entrez:
5
8
2020
pubmed:
5
8
2020
medline:
21
4
2021
Statut:
epublish
Résumé
To compare structural features of the femoral bone of ovariectomized and non-ovariectomized rats after implantation of porous materials (TANTALUM, CONCELOC, TTM, ATLANT). Experiments were carried out on 56 white laboratory female rats aged 6 months. Rats were randomly assigned into groups: sham-operated control group (SH) or ovariectomy group (OVX). Four different commercial implant materials (TTM, CONCELOC, TANTALUM, ATLANT) were placed into the defects (diameter 2.5 mm, depth 3.0 mm) in the distal metaphysis of femurs. Rats were sacrificed 45 days after surgery. Histological study was performed and the percentage of the bone area (BA%) around the implant at a distance of 500 μm in the cancellous area was measured. Formation of mature bone tissue of varying degrees around all of the implants was detected. In OVX rats cancellous bone defect zone was characterized by a high density of osteocytes on the surface. In the SH group, no differences in BA% among implant materials were found. In OVX rats, the BA% around ATLANT implants was 1.5-time less (p = 0.002) than around TANTALUM. The BA% around the rest of the materials was not statistically different. Bone formation around the studied porous titanium and tantalum materials in the osteoporosis model was lower than in normal bone. There were differences in bone formation around the different materials in the osteoporosis model, while in the normal bone model, these differences were absent.
Sections du résumé
BACKGROUND
BACKGROUND
To compare structural features of the femoral bone of ovariectomized and non-ovariectomized rats after implantation of porous materials (TANTALUM, CONCELOC, TTM, ATLANT).
METHODS
METHODS
Experiments were carried out on 56 white laboratory female rats aged 6 months. Rats were randomly assigned into groups: sham-operated control group (SH) or ovariectomy group (OVX). Four different commercial implant materials (TTM, CONCELOC, TANTALUM, ATLANT) were placed into the defects (diameter 2.5 mm, depth 3.0 mm) in the distal metaphysis of femurs. Rats were sacrificed 45 days after surgery. Histological study was performed and the percentage of the bone area (BA%) around the implant at a distance of 500 μm in the cancellous area was measured.
RESULTS
RESULTS
Formation of mature bone tissue of varying degrees around all of the implants was detected. In OVX rats cancellous bone defect zone was characterized by a high density of osteocytes on the surface. In the SH group, no differences in BA% among implant materials were found. In OVX rats, the BA% around ATLANT implants was 1.5-time less (p = 0.002) than around TANTALUM. The BA% around the rest of the materials was not statistically different.
CONCLUSIONS
CONCLUSIONS
Bone formation around the studied porous titanium and tantalum materials in the osteoporosis model was lower than in normal bone. There were differences in bone formation around the different materials in the osteoporosis model, while in the normal bone model, these differences were absent.
Identifiants
pubmed: 32746931
doi: 10.1186/s13018-020-01822-3
pii: 10.1186/s13018-020-01822-3
pmc: PMC7398357
doi:
Substances chimiques
Metals
0
Tantalum
6424HBN274
Titanium
D1JT611TNE
Types de publication
Comparative Study
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
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