A Cytoplasmic Heme Sensor Illuminates the Impacts of Mitochondrial and Vacuolar Functions and Oxidative Stress on Heme-Iron Homeostasis in Cryptococcus neoformans.
Animals
Cell Line
Cryptococcus neoformans
/ genetics
Cytoplasm
/ chemistry
Fluorescence
Fungal Proteins
/ metabolism
Gene Expression Regulation, Fungal
Heme
/ metabolism
Hemin
/ pharmacology
Homeostasis
Iron
/ metabolism
Macrophages
/ microbiology
Mice
Mitochondria
/ metabolism
Oxidative Stress
Saccharomyces cerevisiae
/ genetics
Vacuoles
/ metabolism
Virulence
Virulence Factors
/ metabolism
artemisinin
biosensors
heme sensor
heme-related drugs
macrophage
metformin
mitochondria
reactive oxygen species
vacuole
Journal
mBio
ISSN: 2150-7511
Titre abrégé: mBio
Pays: United States
ID NLM: 101519231
Informations de publication
Date de publication:
28 07 2020
28 07 2020
Historique:
entrez:
30
7
2020
pubmed:
30
7
2020
medline:
13
7
2021
Statut:
epublish
Résumé
Pathogens must compete with hosts to acquire sufficient iron for proliferation during pathogenesis. The pathogenic fungus
Identifiants
pubmed: 32723917
pii: mBio.00986-20
doi: 10.1128/mBio.00986-20
pmc: PMC7387795
pii:
doi:
Substances chimiques
Fungal Proteins
0
Virulence Factors
0
Heme
42VZT0U6YR
Hemin
743LRP9S7N
Iron
E1UOL152H7
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : NIAID NIH HHS
ID : R01 AI053721
Pays : United States
Informations de copyright
Copyright © 2020 Bairwa et al.
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