Diversity-oriented Functionalization of Cyclodienes Through Selective Cycloaddition/Ring-opening/Cross-metathesis Protocols; Transformation of a "Flatland" into Three-dimensional Scaffolds With Stereo- and Regiocontrol.
cross-metathesis
functionalization
selective coupling
β-lactam, isoxazoline
Journal
Chemical record (New York, N.Y.)
ISSN: 1528-0691
Titre abrégé: Chem Rec
Pays: United States
ID NLM: 101085550
Informations de publication
Date de publication:
Oct 2020
Oct 2020
Historique:
received:
11
06
2020
revised:
05
07
2020
accepted:
06
07
2020
pubmed:
29
7
2020
medline:
29
7
2020
entrez:
29
7
2020
Statut:
ppublish
Résumé
This article presents selective transformations of some readily available cyclodienes through simple chemical procedures into novel functionalized small-molecular entities. The syntheses hereby described involved selective cycloadditions, followed by ring-opening metathesis of the resulting β-lactam or isoxazoline derivatives and selective cross-metathesis by differentiation of the olefin bonds on the alkenylated heterocycles. The cross-metathesis transformations have been detailed, which were performed under various experimental conditions with the aim of exploring chemodiscrimination of the olefin bonds and delivering the corresponding functionalized β-lactam or isoxazoline derivatives.
Identifiants
pubmed: 32720742
doi: 10.1002/tcr.202000070
doi:
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
1129-1141Subventions
Organisme : Hungarian Research Foundation
ID : K 119282
Organisme : GINOP
ID : 2.3.2-15-2016-00060
Organisme : EU-funded Hungarian grant
ID : EFOP-3.6.1-16-2016-00008
Organisme : Ministry of Human Capacities, Hungary
ID : 20391-3/2018/FEKUSTRAT
Informations de copyright
© 2020 The Chemical Society of Japan & Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.
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