HIV-1 and HIV-2 prevalence, risk factors and birth outcomes among pregnant women in Bissau, Guinea-Bissau: a retrospective cross-sectional hospital study.
Adolescent
Adult
Anti-Retroviral Agents
/ therapeutic use
Cross-Sectional Studies
Female
Guinea-Bissau
/ epidemiology
HIV Infections
/ diagnosis
HIV-1
/ isolation & purification
HIV-2
/ isolation & purification
Hospitals
Humans
Infant, Low Birth Weight
Infant, Newborn
Infectious Disease Transmission, Vertical
/ prevention & control
Middle Aged
Pregnancy
Prevalence
Retrospective Studies
Risk Factors
Young Adult
Journal
Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288
Informations de publication
Date de publication:
22 07 2020
22 07 2020
Historique:
received:
30
10
2018
accepted:
26
06
2020
entrez:
24
7
2020
pubmed:
24
7
2020
medline:
15
12
2020
Statut:
epublish
Résumé
The human immunodeficiency virus (HIV) remains a leading cause of maternal morbidity and mortality in Sub-Saharan Africa. Prevention of mother-to-child transmission (PMTCT) has proven an effective strategy to end paediatric infections and ensure HIV-infected mothers access treatment. Based on cross-sectional data collected from June 2008 to May 2013, we assessed changes in HIV prevalence, risk factors for HIV, provision of PMTCT antiretroviral treatment (ART), and the association between HIV infection, birth outcomes and maternal characteristics at the Simão Mendes National Hospital, Guinea-Bissau's largest maternity ward. Among 24,107 women, the HIV prevalence was 3.3% for HIV-1, 0.8% for HIV-2 and 0.9% for HIV-1/2. A significant decline in HIV-1, HIV-2, and HIV-1/2 prevalence was observed over time. HIV infection was associated with age and ethnicity. A total of 85% of HIV-infected women received ART as part of PMTCT, yet overall treatment coverage during labour and delivery declined significantly for both mothers and infants. Twenty-two percent of infants did not receive treatment, and 67% of HIV-2-infected mothers and 77% of their infants received ineffective non-nucleoside reverse transcriptase inhibitors for PMTCT. Maternal HIV was associated with low birth weight but not stillbirth. Inadequate continuity of care and ART coverage present challenges to optimal PMTCT in Guinea-Bissau.
Identifiants
pubmed: 32699381
doi: 10.1038/s41598-020-68806-5
pii: 10.1038/s41598-020-68806-5
pmc: PMC7376101
doi:
Substances chimiques
Anti-Retroviral Agents
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
12174Références
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