Comparative assessment of mouse models for experimental orthodontic tooth movement.


Journal

Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288

Informations de publication

Date de publication:
22 07 2020
Historique:
received: 15 04 2020
accepted: 15 06 2020
entrez: 24 7 2020
pubmed: 24 7 2020
medline: 15 12 2020
Statut: epublish

Résumé

Animal experiments are essential for the elucidation of biological-cellular mechanisms in the context of orthodontic tooth movement (OTM). So far, however, no studies comparatively assess available mouse models regarding their suitability. OTM of first upper molars was induced in C57BL/6 mice either via an elastic band or a NiTi coil spring for three, seven or 12 days. We assessed appliance survival rate, OTM and periodontal bone loss (µCT), root resorptions, osteoclastogenesis (TRAP

Identifiants

pubmed: 32699355
doi: 10.1038/s41598-020-69030-x
pii: 10.1038/s41598-020-69030-x
pmc: PMC7376195
doi:

Substances chimiques

Cathepsin K EC 3.4.22.38
Ctsk protein, mouse EC 3.4.22.38

Types de publication

Comparative Study Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

12154

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Auteurs

Christian Kirschneck (C)

Department of Orthodontics, University Medical Centre of Regensburg, 93053, Regensburg, Germany. christian.kirschneck@ukr.de.

Maria Bauer (M)

Department of Orthodontics, University Medical Centre of Regensburg, 93053, Regensburg, Germany.

Joshua Gubernator (J)

Department of Orthodontics, University Medical Centre of Regensburg, 93053, Regensburg, Germany.

Peter Proff (P)

Department of Orthodontics, University Medical Centre of Regensburg, 93053, Regensburg, Germany.

Agnes Schröder (A)

Department of Orthodontics, University Medical Centre of Regensburg, 93053, Regensburg, Germany.

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