The Effect of Methylselenocysteine and Sodium Selenite Treatment on microRNA Expression in Liver Cancer Cell Lines.
Anticarcinogenic Agents
/ pharmacology
Apoptosis
Biomarkers, Tumor
/ genetics
Carcinoma, Hepatocellular
/ drug therapy
Cell Proliferation
Gene Expression Profiling
Gene Expression Regulation, Neoplastic
/ drug effects
Humans
Liver Neoplasms
/ drug therapy
MicroRNAs
/ genetics
Selenocysteine
/ analogs & derivatives
Sodium Selenite
/ pharmacology
Trace Elements
/ pharmacology
Tumor Cells, Cultured
Cholangiocarcinoma
Hepatocellular carcinoma
IC50 value
Methylselenocysteine
Sodium selenite
microRNA expression
Journal
Pathology oncology research : POR
ISSN: 1532-2807
Titre abrégé: Pathol Oncol Res
Pays: Switzerland
ID NLM: 9706087
Informations de publication
Date de publication:
Oct 2020
Oct 2020
Historique:
received:
12
06
2020
accepted:
30
06
2020
pubmed:
14
7
2020
medline:
13
7
2021
entrez:
14
7
2020
Statut:
ppublish
Résumé
The unique character of selenium compounds, including sodium selenite and Se-methylselenocysteine (MSC), is that they exert cytotoxic effects on neoplastic cells, providing a great potential for treating cancer cells being highly resistant to cytostatic drugs. However, selenium treatment may affect microRNA (miRNA) expression as the pattern of circulating miRNAs changed in a placebo-controlled selenium supplement study. This necessitates exploring possible changes in the expression profiles of miRNAs. For this, miRNAs being critical for liver function were selected and their expression was measured in hepatocellular carcinoma (HLE and HLF) and cholangiocarcinoma cell lines (TFK-1 and HuH-28) using individual TaqMan MicroRNA Assays following selenite or MSC treatments. For establishing tolerable concentrations, IC
Identifiants
pubmed: 32656599
doi: 10.1007/s12253-020-00870-8
pii: 10.1007/s12253-020-00870-8
pmc: PMC7471166
doi:
Substances chimiques
Anticarcinogenic Agents
0
Biomarkers, Tumor
0
MicroRNAs
0
Trace Elements
0
Selenocysteine
0CH9049VIS
Sodium Selenite
HIW548RQ3W
selenomethylselenocysteine
TWK220499Z
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
2669-2681Subventions
Organisme : Hungarian Scientific Research Fund
ID : OTKA 128881
Organisme : Hungarian Scientific Research Fund
ID : NVKP_16_1-2016-0004
Organisme : Semmelweis Egyetem
ID : EFOP-3.6.3-VEKOP-16-2017-00009
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