A novel macrolide, solithromycin suppresses mucin overexpression induced by Pseudomonas aeruginosa LPS in airway epithelial cells.
Azithromycin
Immunomodulatory effect
MUC5AC
Journal
Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy
ISSN: 1437-7780
Titre abrégé: J Infect Chemother
Pays: Netherlands
ID NLM: 9608375
Informations de publication
Date de publication:
Sep 2020
Sep 2020
Historique:
received:
08
05
2020
revised:
09
06
2020
accepted:
12
06
2020
pubmed:
12
7
2020
medline:
25
6
2021
entrez:
12
7
2020
Statut:
ppublish
Résumé
Some macrolides such as 14- and 15-membered macrolides have immunomodulatory effects such as suppression of mucin overproduction. Because a novel macrolide, solithromycin, was developed, we examined whether it suppresses the overexpression of mucin in vitro. A human airway epithelial cell line NCI-H292 was stimulated by Pseudomonas aeruginosa lipopolysaccharides to induce the overproduction of a major mucin, MUC5AC. Treatment with 10 μg/mL of solithromycin significantly inhibited LPS-induced MUC5AC in both mRNA and protein levels as well as a 15-membered macrolide, azithromycin. These findings support that solithromycin has a potential immunomodulatory effect.
Identifiants
pubmed: 32651065
pii: S1341-321X(20)30205-1
doi: 10.1016/j.jiac.2020.06.014
pii:
doi:
Substances chimiques
Lipopolysaccharides
0
Macrolides
0
Triazoles
0
solithromycin
9U1ETH79CK
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
1008-1010Informations de copyright
Copyright © 2020 Japanese Society of Chemotherapy and The Japanese Association for Infectious Diseases. Published by Elsevier Ltd. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of Competing Interest The authors have no conflicts of interest to declare.