8-Benzylaminoxanthine scaffold variations for selective ligands acting on adenosine A
Adenosine A(2A)receptors
Anti-inflammatory activity
Metabolic stability
Molecular docking
Monoamine oxidase
Phosphodiesterase
Xanthine derivatives
Journal
Bioorganic chemistry
ISSN: 1090-2120
Titre abrégé: Bioorg Chem
Pays: United States
ID NLM: 1303703
Informations de publication
Date de publication:
08 2020
08 2020
Historique:
received:
24
03
2020
revised:
01
06
2020
accepted:
15
06
2020
pubmed:
7
7
2020
medline:
19
3
2021
entrez:
7
7
2020
Statut:
ppublish
Résumé
A library of 34 novel compounds based on a xanthine scaffold was explored in biological studies for interaction with adenosine receptors (ARs). Structural modifications of the xanthine core were introduced in the 8-position (benzylamino and benzyloxy substitution) as well as at N1, N3, and N7 (small alkyl residues), thereby improving affinity and selectivity for the A
Identifiants
pubmed: 32629282
pii: S0045-2068(20)31330-4
doi: 10.1016/j.bioorg.2020.104033
pii:
doi:
Substances chimiques
Adenosine A2 Receptor Antagonists
0
Ligands
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
104033Informations de copyright
Copyright © 2020. Published by Elsevier Inc.
Déclaration de conflit d'intérêts
Declaration of Competing Interest The authors declared that there is no conflict of interest.