Canine sporotrichosis: polyphasic taxonomy and antifungal susceptibility profiles of Sporothrix species in an endemic area in Brazil.

Amphotericin B / pharmacology Animals Antifungal Agents / pharmacology Brazil / epidemiology Dog Diseases / drug therapy Dogs Itraconazole / pharmacology Ketoconazole / pharmacology Microbial Sensitivity Tests Phylogeny Sporothrix / classification Sporotrichosis / drug therapy Terbinafine / pharmacology
Antifungal susceptibility Dogs Molecular characterization Sporothrix species Sporotrichosis

Journal

Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology]
ISSN: 1678-4405
Titre abrégé: Braz J Microbiol
Pays: Brazil
ID NLM: 101095924

Informations de publication

Date de publication:
Mar 2021
Historique:
received: 01 12 2019
accepted: 25 06 2020
pubmed: 4 7 2020
medline: 26 8 2021
entrez: 4 7 2020
Statut: ppublish

Résumé

Sporotrichosis, a mycosis caused by pathogenic species of the genus Sporothrix, affects diverse species of mammals. Until 2007, Sporothrix schenckii was considered the unique etiologic agent of sporotrichosis. Canine sporotrichosis is a poorly reported disease, and the majority of cases are from Rio de Janeiro, Brazil. There are scarce studies on the characterization of canine isolates of Sporothrix schenckii complex, as well as few antifungal susceptibility data available. The aim of this study was to characterize the clinical isolates of Sporothrix from dogs from Brazil at species level and evaluate their antifungal susceptibility profile. Polyphasic taxonomy was used to characterization at species level (morphological, phenotypical characteristics, and molecular identification). Antifungal susceptibility profiles (amphotericin B, itraconazole, ketoconazole, posaconazole, and terbinafine) were determined using the Clinical and Laboratory Standards Institute broth microdilution method (M38-A2). According to phenotypic identification and molecular analysis, 46 isolates included in this study were identified as S. brasiliensis and one as S. schenckii. Amphotericin B presented the highest minimum inhibitory concentration values, and the other drugs showed effective in vitro antifungal activity. This is the first report of S. schenckii in dogs from Brazil, since S. brasiliensis is the only species that has been described in canine isolates from Rio de Janeiro to date. Nevertheless, no differences were observed in the antifungal susceptibility profiles between the S. brasiliensis and S. schenckii isolates, and it is important to continuously study new canine clinical isolates from Rio de Janeiro, Brazil.

Identifiants

DOI: 10.1007/s42770-020-00328-8 PMID: 32617836 PMC: PMC7966691
pubmed: 32617836
doi: 10.1007/s42770-020-00328-8
pii: 10.1007/s42770-020-00328-8
pmc: PMC7966691
doi:

Substances chimiques

Antifungal Agents 0
Itraconazole 304NUG5GF4
Amphotericin B 7XU7A7DROE
Terbinafine G7RIW8S0XP
Ketoconazole R9400W927I

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

135-143

Subventions

Organisme : Fundação Carlos Chagas Filho de Amparo à Pesquisa do Estado do Rio de Janeiro
ID : E-26/202.737/2019
Organisme : Fundação Carlos Chagas Filho de Amparo à Pesquisa do Estado do Rio de Janeiro
ID : E-26/203.301/2017
Organisme : Conselho Nacional de Desenvolvimento Científico e Tecnológico (BR)
ID : 309657/2016-4
Organisme : Conselho Nacional de Desenvolvimento Científico e Tecnológico (BR)
ID : 304976/2013-0
Organisme : Fundação Carlos Chagas Filho de Amparo à Pesquisa do Estado do Rio de Janeiro (BR)
ID : E-26/103.157/2011
Organisme : Fundação Carlos Chagas Filho de Amparo à Pesquisa do Estado do Rio de Janeiro (BR)
ID : E-26/010.001784/2016
Organisme : Fundação Carlos Chagas Filho de Amparo à Pesquisa do Estado do Rio de Janeiro (BR)
ID : E-26/200.839/2017
Organisme : Coordenação de Aperfeiçoamento de Pessoal de Nível Superior
ID : Finance Code 001

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Auteurs

Jéssica Sepulveda Boechat (JS)

Laboratory of Clinical Research on Dermatozoonoses in Domestic Animals, Evandro Chagas National Institute of Infectious Diseases, Oswaldo Cruz Foundation, Av. Brasil, 4365 - Manguinhos, Rio de Janeiro, 21040-900, Brazil. jessica.boechat@ini.fiocruz.br.
ORCID: 0000-0003-0928-5631

Sandro Antonio Pereira (SA)

Laboratory of Clinical Research on Dermatozoonoses in Domestic Animals, Evandro Chagas National Institute of Infectious Diseases, Oswaldo Cruz Foundation, Av. Brasil, 4365 - Manguinhos, Rio de Janeiro, 21040-900, Brazil.

Ana Caroline de Sá Machado (AC)

Laboratory of Clinical Research on Dermatozoonoses in Domestic Animals, Evandro Chagas National Institute of Infectious Diseases, Oswaldo Cruz Foundation, Av. Brasil, 4365 - Manguinhos, Rio de Janeiro, 21040-900, Brazil.

Paula Gonçalves Viana (PG)

Laboratory of Clinical Research on Dermatozoonoses in Domestic Animals, Evandro Chagas National Institute of Infectious Diseases, Oswaldo Cruz Foundation, Av. Brasil, 4365 - Manguinhos, Rio de Janeiro, 21040-900, Brazil.

Rodrigo Almeida-Paes (R)

Mycology Laboratory, Evandro Chagas National Institute of Infectious Diseases, Oswaldo Cruz Foundation, Rio de Janeiro, Brazil.

Rosely Maria Zancopé-Oliveira (RM)

Mycology Laboratory, Evandro Chagas National Institute of Infectious Diseases, Oswaldo Cruz Foundation, Rio de Janeiro, Brazil.

Isabella Dib Ferreira Gremião (IDF)

Laboratory of Clinical Research on Dermatozoonoses in Domestic Animals, Evandro Chagas National Institute of Infectious Diseases, Oswaldo Cruz Foundation, Av. Brasil, 4365 - Manguinhos, Rio de Janeiro, 21040-900, Brazil.

Manoel Marques Evangelista de Oliveira (MME)

Laboratory of Taxonomy, Biochemistry and Bioprospecting of Fungi, Oswaldo Cruz Institute, Oswaldo Cruz Foundation, Rio de Janeiro, Brazil.

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Classifications MeSH

Recherchemedicale.com › Composés chimiques organiques › Lactones › Amphotéricine B › Canine sporotrichosis: polyphasic taxonomy and...
Recherchemedicale.com › Eucaryotes › Animaux › Canine sporotrichosis: polyphasic taxonomy and...
Recherchemedicale.com › Actions chimiques et utilisations › Actions pharmacologiques › Utilisations thérapeutiques › Anti-infectieux › Antifongiques › Canine sporotrichosis: polyphasic taxonomy and...
Recherchemedicale.com › Régions géographiques › Amériques › Amérique du Sud › Brésil › Canine sporotrichosis: polyphasic taxonomy and...
Recherchemedicale.com › Maladies de l'animal › Maladies des chiens › Canine sporotrichosis: polyphasic taxonomy and...
Recherchemedicale.com › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Carnivora › Pinnipedia › Canidae › Chiens › Canine sporotrichosis: polyphasic taxonomy and...
Recherchemedicale.com › Composés hétérocycliques › Composés hétéromonocycliques › Pipérazines › Itraconazole › Canine sporotrichosis: polyphasic taxonomy and...
Recherchemedicale.com › Composés hétérocycliques › Composés hétéromonocycliques › Pipérazines › Kétoconazole › Canine sporotrichosis: polyphasic taxonomy and...
Recherchemedicale.com › Techniques d'investigation › Évaluation préclinique de médicament › Tests de sensibilité microbienne › Canine sporotrichosis: polyphasic taxonomy and...
Recherchemedicale.com › Sciences de l'information › Phylogenèse › Canine sporotrichosis: polyphasic taxonomy and...
Recherchemedicale.com › Eucaryotes › Champignons › Deuteromycota › Sporothrix › Canine sporotrichosis: polyphasic taxonomy and...
Recherchemedicale.com › Maladies de la peau et du tissu conjonctif › Maladies de la peau › Infections de la peau › Mycoses cutanées › Sporotrichose › Canine sporotrichosis: polyphasic taxonomy and...
Recherchemedicale.com › Composés polycycliques › Hydrocarbures aromatiques polycycliques › Naphtalènes › Terbinafine › Canine sporotrichosis: polyphasic taxonomy and...