Steady-state cerebral autoregulation in older adults with amnestic mild cognitive impairment: linear mixed model analysis.

Aged Blood Pressure Cerebrovascular Circulation Cognitive Dysfunction Homeostasis Humans Nitroprusside
Alzheimer disease cerebral autoregulation cerebral blood flow linear mixed model mild cognitive impairment

Journal

Journal of applied physiology (Bethesda, Md. : 1985)
ISSN: 1522-1601
Titre abrégé: J Appl Physiol (1985)
Pays: United States
ID NLM: 8502536

Informations de publication

Date de publication:
01 08 2020
Historique:
pubmed: 3 7 2020
medline: 24 6 2021
entrez: 3 7 2020
Statut: ppublish

Résumé

We examined whether the efficacy of steady-state cerebral autoregulation (CA) is reduced in older adults with amnestic mild cognitive impairment (aMCI), a prodromal stage of clinical Alzheimer disease (AD). Forty-two patients with aMCI and 24 cognitively normal older adults (NC) of similar age, sex, and education underwent stepwise decreases and increases in mean arterial pressure (MAP) induced by intravenous infusion of sodium nitroprusside and phenylephrine, respectively. Changes in cerebral blood flow (CBF) were measured repeatedly in the internal carotid and vertebral artery. Linear mixed modeling, including random effects of both individual intercept and regression slope, was used to quantify the MAP-CBF relationship accounting for nonindependent, repeated CBF measures. Changes in end-tidal CO

Identifiants

DOI: 10.1152/japplphysiol.00193.2020 PMID: 32614686 PMC: PMC7473943
pubmed: 32614686
doi: 10.1152/japplphysiol.00193.2020
pmc: PMC7473943
doi:

Substances chimiques

Nitroprusside 169D1260KM

Types de publication

Journal Article Research Support, N.I.H., Extramural

Langues

eng

Sous-ensembles de citation

IM

Pagination

377-385

Subventions

Organisme : NHLBI NIH HHS
ID : R01 HL102457
Pays : United States
Organisme : NIH HHS
ID : R01AG033106
Pays : United States
Organisme : NIH HHS
ID : R01HL102457
Pays : United States

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Auteurs

Li Zhang (L)

Institute for Exercise and Environmental Medicine, Texas Health Presbyterian Hospital, Dallas, Texas.
Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas.
Department of Ultrasound Diagnostics, Tangdu Hospital, Xi'an, China.

Evan P Pasha (EP)

Institute for Exercise and Environmental Medicine, Texas Health Presbyterian Hospital, Dallas, Texas.
Department of Neurology and Neurotherapeutics, University of Texas Southwestern Medical Center, Dallas, Texas.

Jie Liu (J)

Institute for Exercise and Environmental Medicine, Texas Health Presbyterian Hospital, Dallas, Texas.
Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas.
ORCID: 0000-0002-7441-2417

Chang-Yang Xing (CY)

Institute for Exercise and Environmental Medicine, Texas Health Presbyterian Hospital, Dallas, Texas.
Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas.
Department of Ultrasound Diagnostics, Tangdu Hospital, Xi'an, China.

Danilo Cardim (D)

Institute for Exercise and Environmental Medicine, Texas Health Presbyterian Hospital, Dallas, Texas.
Department of Neurology and Neurotherapeutics, University of Texas Southwestern Medical Center, Dallas, Texas.

Takashi Tarumi (T)

Institute for Exercise and Environmental Medicine, Texas Health Presbyterian Hospital, Dallas, Texas.
Department of Neurology and Neurotherapeutics, University of Texas Southwestern Medical Center, Dallas, Texas.

Kyle Womack (K)

Department of Neurology and Neurotherapeutics, University of Texas Southwestern Medical Center, Dallas, Texas.

Linda S Hynan (LS)

Department of Population and Data Sciences, University of Texas Southwestern Medical Center, Dallas, Texas.
Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas, Texas.

C Munro Cullum (CM)

Department of Neurology and Neurotherapeutics, University of Texas Southwestern Medical Center, Dallas, Texas.
Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas, Texas.
Department of Neurological Surgery, University of Texas Southwestern Medical Center, Dallas, Texas.

Rong Zhang (R)

Institute for Exercise and Environmental Medicine, Texas Health Presbyterian Hospital, Dallas, Texas.
Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas.
Department of Neurology and Neurotherapeutics, University of Texas Southwestern Medical Center, Dallas, Texas.

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Classifications MeSH

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