Cofactor-enabled functional expression of fruit fly, honeybee, and bumblebee nicotinic receptors reveals picomolar neonicotinoid actions.
Acetylcholine
/ pharmacology
Animals
Bees
/ metabolism
Dose-Response Relationship, Drug
Drosophila melanogaster
/ metabolism
Insect Proteins
/ agonists
Insecticides
/ pharmacology
Neonicotinoids
/ pharmacology
Nicotinic Agonists
/ pharmacology
Oocytes
/ metabolism
Protein Subunits
/ antagonists & inhibitors
Receptors, Nicotinic
/ genetics
Thioredoxins
/ genetics
Xenopus laevis
bumblebee
fruit fly
honeybee
neonicotinoids
nicotinic acetylcholine receptors
Journal
Proceedings of the National Academy of Sciences of the United States of America
ISSN: 1091-6490
Titre abrégé: Proc Natl Acad Sci U S A
Pays: United States
ID NLM: 7505876
Informations de publication
Date de publication:
14 07 2020
14 07 2020
Historique:
pubmed:
3
7
2020
medline:
24
9
2020
entrez:
3
7
2020
Statut:
ppublish
Résumé
The difficulty of achieving robust functional expression of insect nicotinic acetylcholine receptors (nAChRs) has hampered our understanding of these important molecular targets of globally deployed neonicotinoid insecticides at a time when concerns have grown regarding the toxicity of this chemotype to insect pollinators. We show that thioredoxin-related transmembrane protein 3 (TMX3) is essential to enable robust expression in
Identifiants
pubmed: 32611810
pii: 2003667117
doi: 10.1073/pnas.2003667117
pmc: PMC7368294
doi:
Substances chimiques
Insect Proteins
0
Insecticides
0
Neonicotinoids
0
Nicotinic Agonists
0
Protein Subunits
0
Receptors, Nicotinic
0
Thioredoxins
52500-60-4
Acetylcholine
N9YNS0M02X
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
16283-16291Informations de copyright
Copyright © 2020 the Author(s). Published by PNAS.
Déclaration de conflit d'intérêts
The authors declare no competing interest.
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