Phosphoregulation of a Conserved Herpesvirus Tegument Protein by a Virally Encoded Protein Kinase in Viral Pathogenicity and Potential Linkage between Its Evolution and Viral Phylogeny.


Journal

Journal of virology
ISSN: 1098-5514
Titre abrégé: J Virol
Pays: United States
ID NLM: 0113724

Informations de publication

Date de publication:
31 08 2020
Historique:
received: 27 05 2020
accepted: 23 06 2020
pubmed: 3 7 2020
medline: 25 11 2020
entrez: 3 7 2020
Statut: epublish

Résumé

Us3 proteins of herpes simplex virus 1 (HSV-1) and HSV-2 are multifunctional serine-threonine protein kinases. Here, we identified an HSV-2 tegument protein, UL7, as a novel physiological substrate of HSV-2 Us3. Mutations in HSV-2 UL7, which precluded Us3 phosphorylation of the viral protein, significantly reduced mortality, viral replication in the vagina, and development of vaginal disease in mice following vaginal infection. These results indicated that Us3 phosphorylation of UL7 in HSV-2 was required for efficient viral replication and pathogenicity

Identifiants

pubmed: 32611749
pii: JVI.01055-20
doi: 10.1128/JVI.01055-20
pmc: PMC7459551
pii:
doi:

Substances chimiques

Protein Isoforms 0
UL7 protein, human herpesvirus 1 0
Viral Matrix Proteins 0
Viral Proteins 0
Viral Structural Proteins 0
Protein Serine-Threonine Kinases EC 2.7.11.1
US3 protein, Human herpesvirus 2 EC 2.7.11.1

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Informations de copyright

Copyright © 2020 American Society for Microbiology.

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Auteurs

Misato Shibazaki (M)

Division of Molecular Virology, Department of Microbiology and Immunology, Institute of Medical Science, University of Tokyo, Tokyo, Japan.
Department of Infectious Disease Control, International Research Center for Infectious Diseases, Institute of Medical Science, University of Tokyo, Tokyo, Japan.

Akihisa Kato (A)

Division of Molecular Virology, Department of Microbiology and Immunology, Institute of Medical Science, University of Tokyo, Tokyo, Japan.
Department of Infectious Disease Control, International Research Center for Infectious Diseases, Institute of Medical Science, University of Tokyo, Tokyo, Japan.
Research Center for Asian Infectious Diseases, Institute of Medical Science, University of Tokyo, Tokyo, Japan.

Kosuke Takeshima (K)

Division of Molecular Virology, Department of Microbiology and Immunology, Institute of Medical Science, University of Tokyo, Tokyo, Japan.
Department of Infectious Disease Control, International Research Center for Infectious Diseases, Institute of Medical Science, University of Tokyo, Tokyo, Japan.

Jumpei Ito (J)

Department of Infectious Disease Control, International Research Center for Infectious Diseases, Institute of Medical Science, University of Tokyo, Tokyo, Japan.

Mai Suganami (M)

Department of Infectious Disease Control, International Research Center for Infectious Diseases, Institute of Medical Science, University of Tokyo, Tokyo, Japan.

Naoto Koyanagi (N)

Division of Molecular Virology, Department of Microbiology and Immunology, Institute of Medical Science, University of Tokyo, Tokyo, Japan.
Department of Infectious Disease Control, International Research Center for Infectious Diseases, Institute of Medical Science, University of Tokyo, Tokyo, Japan.
Research Center for Asian Infectious Diseases, Institute of Medical Science, University of Tokyo, Tokyo, Japan.

Yuhei Maruzuru (Y)

Division of Molecular Virology, Department of Microbiology and Immunology, Institute of Medical Science, University of Tokyo, Tokyo, Japan.
Department of Infectious Disease Control, International Research Center for Infectious Diseases, Institute of Medical Science, University of Tokyo, Tokyo, Japan.
Research Center for Asian Infectious Diseases, Institute of Medical Science, University of Tokyo, Tokyo, Japan.

Kei Sato (K)

Department of Infectious Disease Control, International Research Center for Infectious Diseases, Institute of Medical Science, University of Tokyo, Tokyo, Japan.

Yasushi Kawaguchi (Y)

Division of Molecular Virology, Department of Microbiology and Immunology, Institute of Medical Science, University of Tokyo, Tokyo, Japan ykawagu@ims.u-tokyo.ac.jp.
Department of Infectious Disease Control, International Research Center for Infectious Diseases, Institute of Medical Science, University of Tokyo, Tokyo, Japan.
Research Center for Asian Infectious Diseases, Institute of Medical Science, University of Tokyo, Tokyo, Japan.

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Classifications MeSH