Using a developmental perspective to examine the moderating effects of marriage on heavy episodic drinking in a young adult sample enriched for risk.
alcohol
development
genetics
marital status
young adults
Journal
Development and psychopathology
ISSN: 1469-2198
Titre abrégé: Dev Psychopathol
Pays: United States
ID NLM: 8910645
Informations de publication
Date de publication:
08 2021
08 2021
Historique:
pubmed:
3
7
2020
medline:
24
8
2021
entrez:
3
7
2020
Statut:
ppublish
Résumé
Many studies demonstrate that marriage protects against risky alcohol use and moderates genetic influences on alcohol outcomes; however, previous work has not considered these effects from a developmental perspective or in high-risk individuals. These represent important gaps, as it cannot be assumed that marriage has uniform effects across development or in high-risk samples. We took a longitudinal developmental approach to examine whether marital status was associated with heavy episodic drinking (HED), and whether marital status moderated polygenic influences on HED. Our sample included 937 individuals (53.25% female) from the Collaborative Study on the Genetics of Alcoholism who reported their HED and marital status biennially between the ages of 21 and 25. Polygenic risk scores (PRS) were derived from a genome-wide association study of alcohol consumption. Marital status was not associated with HED; however, we observed pathogenic gene-by-environment effects that changed across young adulthood. Among those who married young (age 21), individuals with higher PRS reported more HED; however, these effects decayed over time. The same pattern was found in supplementary analyses using parental history of alcohol use disorder as the index of genetic liability. Our findings indicate that early marriage may exacerbate risk for those with higher polygenic load.
Identifiants
pubmed: 32611468
doi: 10.1017/S0954579420000371
pii: S0954579420000371
pmc: PMC7775899
mid: NIHMS1577623
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1097-1106Subventions
Organisme : NHGRI NIH HHS
ID : U01 HG004438
Pays : United States
Organisme : NCRR NIH HHS
ID : UL1 RR024992
Pays : United States
Organisme : NHGRI NIH HHS
ID : HHSN268200782096C
Pays : United States
Organisme : NIAAA NIH HHS
ID : K01 AA024152
Pays : United States
Organisme : NIAAA NIH HHS
ID : U10 AA008401
Pays : United States
Organisme : NCATS NIH HHS
ID : UL1 TR002345
Pays : United States
Organisme : NIAAA NIH HHS
ID : K02 AA018755
Pays : United States
Organisme : NCI NIH HHS
ID : P30 CA091842
Pays : United States
Commentaires et corrections
Type : ErratumIn
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