False Rifampicin Resistance in Xpert Ultra Applied to Lymph Node Aspirate: A Case Report.

Xpert Ultra extrapulmonary tuberculosis false mutant melting temperature false rifampicin resistance lymph node

Journal

Open forum infectious diseases
ISSN: 2328-8957
Titre abrégé: Open Forum Infect Dis
Pays: United States
ID NLM: 101637045

Informations de publication

Date de publication:
Jun 2020
Historique:
received: 14 02 2020
accepted: 29 05 2020
entrez: 2 7 2020
pubmed: 2 7 2020
medline: 2 7 2020
Statut: epublish

Résumé

A 36-year-old male patient was diagnosed with tuberculosis in Antwerp, Belgium, in May 2018. His lymph node aspirate initially tested rifampicin resistant in Xpert MTB/RIF Ultra, but tested susceptible in all other tests including targeted deep sequencing due to a rare matrix effect in the Xpert MTB/RIF Ultra reaction tube.

Identifiants

pubmed: 32607388
doi: 10.1093/ofid/ofaa204
pii: ofaa204
pmc: PMC7307434
doi:

Types de publication

Journal Article

Langues

eng

Pagination

ofaa204

Informations de copyright

© The Author(s) 2020. Published by Oxford University Press on behalf of Infectious Diseases Society of America.

Références

J Clin Microbiol. 2018 Aug 27;56(9):
pubmed: 29950333
J Clin Microbiol. 2018 Aug 27;56(9):
pubmed: 29925643
Int J Infect Dis. 2019 Apr;81:91-96
pubmed: 30738907
J Clin Microbiol. 2019 Oct 23;57(11):
pubmed: 31413081
mBio. 2017 Aug 29;8(4):
pubmed: 28851844

Auteurs

Kamela C S Ng (KCS)

Mycobacteriology Unit, Department of Biomedical Sciences, Institute of Tropical Medicine, Antwerp, Belgium.
Department of Global Health and Social Medicine, Harvard Medical School, Boston, Massachusetts, United States.

Leen Rigouts (L)

Mycobacteriology Unit, Department of Biomedical Sciences, Institute of Tropical Medicine, Antwerp, Belgium.

Bouke C de Jong (BC)

Mycobacteriology Unit, Department of Biomedical Sciences, Institute of Tropical Medicine, Antwerp, Belgium.

Lutgarde Lynen (L)

HIV/TB Unit, Department of Clinical Sciences, Institute of Tropical Medicine, Antwerp, Belgium.

Classifications MeSH