Retrospective study on the potential of albumin/globulin ratio as a prognostic biomarker for oral cavity cancer patients.
Albumin/globulin ratio
Multivariate prognostic model
Nomogram
Oral cavity squamous cell carcinoma
Overall survival
Journal
European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery
ISSN: 1434-4726
Titre abrégé: Eur Arch Otorhinolaryngol
Pays: Germany
ID NLM: 9002937
Informations de publication
Date de publication:
Jan 2021
Jan 2021
Historique:
received:
02
05
2020
accepted:
16
06
2020
pubmed:
26
6
2020
medline:
28
4
2021
entrez:
26
6
2020
Statut:
ppublish
Résumé
Although the serum albumin/globulin ratio (AGR) is recognized as a valuable prognostic biomarker in various cancers, its clinical value in oral cavity squamous cell carcinoma (OSCC) is still unclear. We aimed to probe the prognostic value of AGR in patients with OSCC undergoing curative surgery. This retrospective study analyzed 306 patients who were newly diagnosed as having OSCC and receiving curative surgery between 2008 and 2017. The correlation of AGR with survival outcomes was estimated using Cox proportional hazards models and Kaplan-Meier analysis. A nomogram based on AGR was established, and its accuracy was assessed according to the concordance index. The log rank test and Kaplan-Meier analysis indicated that patients who had low AGR had significantly shorter disease-free survival (DFS) as well as 5-year overall survival (OS) than those with high AGR. The multivariate Cox analysis revealed that low AGR was an independent predictor of poor OS and DFS (adjusted hazard ratio [aHR] = 2.812; 95% CI 1.729-4.573; p < 0.001, and aHR = 1.743; 95% CI 1.201-2.530; p = 0.003, respectively). The concordance index of the nomogram model based on TNM staging alone was 0.656 and could increase to 0.783 with the inclusion of AGR and other prognostic variables in the calculation. Preoperative AGR may represent an accessible, valuable prognostic biomarker in patients with OSCC. The nomogram model incorporating AGR and clinicopathological prognostic variables may improve the accuracy of prognostic predictions in these patients.
Identifiants
pubmed: 32583177
doi: 10.1007/s00405-020-06145-x
pii: 10.1007/s00405-020-06145-x
doi:
Substances chimiques
Biomarkers
0
Globulins
0
Serum Albumin
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
227-238Subventions
Organisme : Chiayi Chang Gung Memorial Hospital
ID : CMRPG6G0342
Références
Rivera C (2015) Essentials of oral cancer. Int J Clin Exp Pathol 8:11884–11894
pubmed: 26617944
pmcid: 4637760
Health Promotion Administration MOHaW, Taiwan (2016) Cancer Registry Annual Report 2016
Kao SY, Lim E (2015) An overview of detection and screening of oral cancer in Taiwan. Chin J Dent Res 18:7–12
pubmed: 25815378
Omura K (2014) Current status of oral cancer treatment strategies: surgical treatments for oral squamous cell carcinoma. Int J Clin Oncol 19:423–430
doi: 10.1007/s10147-014-0689-z
Ettinger KS, Ganry L, Fernandes RP (2019) Oral cavity cancer. Oral Maxillofac Surg Clin North Am 31:13–29
doi: 10.1016/j.coms.2018.08.002
Scully C, Moles DR (2008) Oral Cancer. In: Heggenhougen HK (ed) International encyclopedia of public health. Academic Press, Oxford, pp 668–677
doi: 10.1016/B978-012373960-5.00256-2
Liao C-T, Lin C-Y, Fan K-H et al (2015) The optimal treatment modality for taiwan oral cavity cancer patients-experience of a medical center. J Cancer Res Pract 2:103–116
Chinn SB, Myers JN (2015) Oral cavity carcinoma: current management, controversies, and future directions. J Clin Oncol 33:3269–3276
doi: 10.1200/JCO.2015.61.2929
Eltohami YI, Kao HK, Lao WW et al (2018) The prediction value of the systemic inflammation score for oral cavity squamous cell carcinoma. Otolaryngol Head Neck Surg 158:1042–1050
doi: 10.1177/0194599817751678
Sobin LH (2003) TNM: evolution and relation to other prognostic factors. Semin Surg Oncol 21:3–7
doi: 10.1002/ssu.10014
Rivera C, Oliveira AK, RaP C et al (2017) Prognostic biomarkers in oral squamous cell carcinoma: a systematic review. Oral Oncol 72:38–47
doi: 10.1016/j.oraloncology.2017.07.003
Lim WS, Roh JL, Kim SB et al (2017) Pretreatment albumin level predicts survival in head and neck squamous cell carcinoma. Laryngoscope 127:E437–E442
doi: 10.1002/lary.26691
Moon H, Roh JL, Lee SW et al (2016) Prognostic value of nutritional and hematologic markers in head and neck squamous cell carcinoma treated by chemoradiotherapy. Radiother Oncol 118:330–334
doi: 10.1016/j.radonc.2015.10.029
Tampa M, Mitran MI, Mitran CI et al (2018) Mediators of inflammation—a potential source of biomarkers in oral squamous cell carcinoma. J Immunol Res 2018:1061780
doi: 10.1155/2018/1061780
Deng T, Lyon CJ, Bergin S et al (2016) Obesity, inflammation, and cancer. Annu Rev Pathol 11:421–449
doi: 10.1146/annurev-pathol-012615-044359
Mcmillan DC (2009) Systemic inflammation, nutritional status and survival in patients with cancer. Curr Opin Clin Nutr Metab Care 12:223–226
doi: 10.1097/MCO.0b013e32832a7902
Zhou T, Yu ST, Chen WZ et al (2019) Pretreatment albumin globulin ratio has a superior prognostic value in laryngeal squamous cell carcinoma patients: a comparison study. J Cancer 10:594–601
doi: 10.7150/jca.28817
Mcmillan DC, Watson WS, O’gorman P et al (2001) Albumin concentrations are primarily determined by the body cell mass and the systemic inflammatory response in cancer patients with weight loss. Nutr Cancer 39:210–213
doi: 10.1207/S15327914nc392_8
Tsai MH, Chuang HC, Lin YT et al (2018) Clinical impact of albumin in advanced head and neck cancer patients with free flap reconstruction-a retrospective study. PeerJ 6:e4490
doi: 10.7717/peerj.4490
Oki S, Toiyama Y, Okugawa Y et al (2017) Clinical burden of preoperative albumin-globulin ratio in esophageal cancer patients. Am J Surg 214:891–898
doi: 10.1016/j.amjsurg.2017.04.007
Hachiya H, Ishizuka M, Takagi K et al (2018) Clinical significance of the globulin-to-albumin ratio for prediction of postoperative survival in patients with colorectal cancer. Ann Gastroenterol Surg 2:434–441
doi: 10.1002/ags3.12201
Zhou T, He X, Fang W et al (2016) Pretreatment albumin/globulin ratio predicts the prognosis for small-cell lung cancer. Medicine (Baltimore) 95:e3097
doi: 10.1097/MD.0000000000003097
Du XJ, Tang LL, Mao YP et al (2014) The pretreatment albumin to globulin ratio has predictive value for long-term mortality in nasopharyngeal carcinoma. PLoS ONE 9:e94473
doi: 10.1371/journal.pone.0094473
He X, Guo S, Chen D et al (2017) Preoperative albumin to globulin ratio (AGR) as prognostic factor in renal cell carcinoma. J Cancer 8:258–265
doi: 10.7150/jca.16525
Deng Y, Pang Q, Miao RC et al (2016) Prognostic significance of pretreatment albumin/globulin ratio in patients with hepatocellular carcinoma. Onco Targets Ther 9:5317–5328
doi: 10.2147/OTT.S109736
Azab BN, Bhatt VR, Vonfrolio S et al (2013) Value of the pretreatment albumin to globulin ratio in predicting long-term mortality in breast cancer patients. Am J Surg 206:764–770
doi: 10.1016/j.amjsurg.2013.03.007
Jariod-Ferrer UM, Arbones-Mainar JM, Gavin-Clavero MA et al (2019) Are comorbidities associated with overall survival in patients with oral squamous cell carcinoma? J Oral Maxillofac Surg 77:1906–1914
doi: 10.1016/j.joms.2019.03.007
Lazennec G, Richmond A (2010) Chemokines and chemokine receptors: new insights into cancer-related inflammation. Trends Mol Med 16:133–144
doi: 10.1016/j.molmed.2010.01.003
Toiyama Y, Yasuda H, Ohi M et al (2017) Clinical impact of preoperative albumin to globulin ratio in gastric cancer patients with curative intent. Am J Surg 213:120–126
doi: 10.1016/j.amjsurg.2016.05.012
Suh B, Park S, Shin DW et al (2014) Low albumin-to-globulin ratio associated with cancer incidence and mortality in generally healthy adults. Ann Oncol 25:2260–2266
doi: 10.1093/annonc/mdu274
Lv GY, An L, Sun XD et al (2018) Pretreatment albumin to globulin ratio can serve as a prognostic marker in human cancers: a meta-analysis. Clin Chim Acta 476:81–91
doi: 10.1016/j.cca.2017.11.019
Van Bokhorst-De Van Der S, Van Leeuwen PA, Kuik DJ et al (1999) The impact of nutritional status on the prognoses of patients with advanced head and neck cancer. Cancer 86:519–527
doi: 10.1002/(SICI)1097-0142(19990801)86:3<519::AID-CNCR22>3.0.CO;2-S
Liu J, Dai Y, Zhou F et al (2016) The prognostic role of preoperative serum albumin/globulin ratio in patients with bladder urothelial carcinoma undergoing radical cystectomy. Urol Oncol 34(484):e481–484 (e488)
Laky B, Janda M, Cleghorn G et al (2008) Comparison of different nutritional assessments and body-composition measurements in detecting malnutrition among gynecologic cancer patients. Am J Clin Nutr 87:1678–1685
doi: 10.1093/ajcn/87.6.1678
Chen WZ, Yu ST, Xie R et al (2017) Preoperative albumin/globulin ratio has predictive value for patients with laryngeal squamous cell carcinoma. Oncotarget 8:48240–48247
doi: 10.18632/oncotarget.18443
Gabay C, Kushner I (1999) Acute-phase proteins and other systemic responses to inflammation. N Engl J Med 340:448–454
doi: 10.1056/NEJM199902113400607
Vinzenz K, Pavelka R, Schonthal E et al (1986) Serum immunoglobulin levels in patients with head and neck cancer (IgE, IgA, IgM, IgG). Oncology 43:316–322
doi: 10.1159/000226390
Chi J, Xie Q, Jia J et al (2018) Prognostic value of albumin/globulin ratio in survival and lymph node metastasis in patients with cancer: a systematic review and meta-analysis. J Cancer 9:2341–2348
doi: 10.7150/jca.24889
Gundog M, Basaran H (2019) Pretreatment low prognostic nutritional index and low albumin-globulin ratio are predictive for overall survival in nasopharyngeal cancer. Eur Arch Otorhinolaryngol 276:3221–3230
doi: 10.1007/s00405-019-05595-2
Montero PH, Yu C, Palmer FL et al (2014) Nomograms for preoperative prediction of prognosis in patients with oral cavity squamous cell carcinoma. Cancer 120:214–221
doi: 10.1002/cncr.28407