Rodent Model of Muscular Atrophy for Sarcopenia Study.

Aging Muscle, skeletal Muscular atrophy Rodentia Sarcopenia

Journal

Journal of bone metabolism
ISSN: 2287-6375
Titre abrégé: J Bone Metab
Pays: Korea (South)
ID NLM: 101599927

Informations de publication

Date de publication:
May 2020
Historique:
received: 22 04 2020
revised: 15 05 2020
accepted: 16 05 2020
entrez: 24 6 2020
pubmed: 24 6 2020
medline: 24 6 2020
Statut: ppublish

Résumé

The hallmark symptom of sarcopenia is the loss of muscle mass and strength without the loss of overall body weight. Sarcopenia patients are likely to have worse clinical outcomes and higher mortality than do healthy individuals. The sarcopenia population shows an annual increase of ~0.8% in the population after age 50, and the prevalence rate is rapidly increasing with the recent worldwide aging trend. Based on International Classification of Diseases, Tenth Revision, a global classification of disease published by the World Health Organization, issued the disease code (M62.84) given to sarcopenia in 2016. Therefore, it is expected that the study of sarcopenia will be further activated based on the classification of disease codes in the aging society. Several epidemiological studies and meta-analyses have looked at the correlation between the prevalence of sarcopenia and several environmental factors. In addition, studies using cell lines and rodents have been done to understand the biological mechanism of sarcopenia. Laboratory rodent models are widely applicable in sarcopenia studies because of the advantages of time savings, cost saving, and various analytical applications that could not be used for human subjects. The rodent models that can be applied to the sarcopenia research are diverse, but a simple and fast method that can cause atrophy or aging is preferred. Therefore, we will introduce various methods of inducing muscular atrophy in rodent models to be applied to the study of sarcopenia.

Identifiants

pubmed: 32572370
doi: 10.11005/jbm.2020.27.2.97
pmc: PMC7297619
doi:

Types de publication

Journal Article Review

Langues

eng

Pagination

97-110

Informations de copyright

Copyright © 2020 The Korean Society for Bone and Mineral Research.

Déclaration de conflit d'intérêts

Conflict of interest: No potential conflict of interest relevant to this article was reported.

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Auteurs

Kyung-Wan Baek (KW)

Department of Physical Education, Gyeongsang National University, Jinju, Korea.
Department of Orthopaedic Surgery, Gyoengsang National University Hospital, Gyeongsang National University, Jinju, Korea.

Youn-Kwan Jung (YK)

Biomedical Research Institute, Gyoengsang National University Hospital, Gyeongsang National University, Jinju, Korea.

Ji-Seok Kim (JS)

Department of Physical Education, Gyeongsang National University, Jinju, Korea.

Jin Sung Park (JS)

Department of Orthopaedic Surgery, Gyoengsang National University Hospital, Gyeongsang National University, Jinju, Korea.

Young-Sool Hah (YS)

Biomedical Research Institute, Gyoengsang National University Hospital, Gyeongsang National University, Jinju, Korea.

So-Jeong Kim (SJ)

Department of Convergence of Medical Sciences, Gyeongsang National University, Jinju, Korea.

Jun-Il Yoo (JI)

Department of Orthopaedic Surgery, Gyoengsang National University Hospital, Gyeongsang National University, Jinju, Korea.

Classifications MeSH