Acute Effect of a Protein Supplement on Targeted Plasma Amino Acid Profile among Healthy Asian Indians: A Randomized Controlled Trial.
Journal
Journal of nutrition and metabolism
ISSN: 2090-0724
Titre abrégé: J Nutr Metab
Pays: United States
ID NLM: 101526296
Informations de publication
Date de publication:
2020
2020
Historique:
received:
30
11
2019
revised:
06
03
2020
accepted:
16
04
2020
entrez:
23
6
2020
pubmed:
23
6
2020
medline:
23
6
2020
Statut:
epublish
Résumé
Indians have a poor protein intake in terms of quantity as well as quality because of their predominantly cereal-based diet. However, there is limited information on circulatory amino acid levels in healthy Indians. Herein, we evaluated the acute effect of a protein supplement on the plasma levels of essential amino acids (EAAs) in healthy Indian adults, using targeted EAA analysis. In this double-blind, randomized, crossover study, 20 healthy Indian adults were randomized to receive the test protein supplement (treatment arm, At baseline, mean plasma levels did not differ significantly between the two arms for any of the EAAs. In the treatment arm, the mean levels of all EAAs increased significantly from baseline to 60 min ( Compared to placebo, protein supplement increased circulatory amino acid levels in healthy Indians. The observed increase in EAA levels and its role in conjunction with exercise in both healthy and diseased states need to be further evaluated. This is the first dataset exploring targeted EAA profiles and the effect of a protein supplement among healthy Indians. The clinical trial is registered with CTRI/2018/12/016777.
Sections du résumé
BACKGROUND
BACKGROUND
Indians have a poor protein intake in terms of quantity as well as quality because of their predominantly cereal-based diet. However, there is limited information on circulatory amino acid levels in healthy Indians. Herein, we evaluated the acute effect of a protein supplement on the plasma levels of essential amino acids (EAAs) in healthy Indian adults, using targeted EAA analysis.
METHODS
METHODS
In this double-blind, randomized, crossover study, 20 healthy Indian adults were randomized to receive the test protein supplement (treatment arm,
RESULTS
RESULTS
At baseline, mean plasma levels did not differ significantly between the two arms for any of the EAAs. In the treatment arm, the mean levels of all EAAs increased significantly from baseline to 60 min (
CONCLUSION
CONCLUSIONS
Compared to placebo, protein supplement increased circulatory amino acid levels in healthy Indians. The observed increase in EAA levels and its role in conjunction with exercise in both healthy and diseased states need to be further evaluated. This is the first dataset exploring targeted EAA profiles and the effect of a protein supplement among healthy Indians. The clinical trial is registered with CTRI/2018/12/016777.
Identifiants
pubmed: 32566281
doi: 10.1155/2020/8946820
pmc: PMC7285395
doi:
Types de publication
Journal Article
Langues
eng
Pagination
8946820Informations de copyright
Copyright © 2020 Ammu Kurien et al.
Déclaration de conflit d'intérêts
The coauthors Madhavi Marathe and Nandan Joshi are employees of Nutricia International Private Limited, a subsidiary of Danone. None of the other authors have any conflicts of interest to declare.
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