Cervicovaginal fluid cytokines as predictive markers of preterm birth in symptomatic women.
Biomarkers
Cytokines
Interleukin-17A
Interleukin-6
Preterm birth
Journal
Obstetrics & gynecology science
ISSN: 2287-8572
Titre abrégé: Obstet Gynecol Sci
Pays: Korea (South)
ID NLM: 101602614
Informations de publication
Date de publication:
Jul 2020
Jul 2020
Historique:
received:
26
07
2019
accepted:
15
04
2020
pubmed:
20
6
2020
medline:
20
6
2020
entrez:
20
6
2020
Statut:
ppublish
Résumé
Here, we investigated whether cytokines in the cervicovaginal fluid (CVF) can be predictive markers of preterm birth (PTB). A multi-center prospective cohort study was conducted on 59 singleton pregnant women hospitalized for preterm labor (PTL) and/or preterm premature rupture of membranes (pPROM) between 22 weeks and 36 weeks 6 days of gestation from 2014 to 2015. The levels of 13 inflammatory cytokines (macrophage inflammatory protein [MIP]-1α, MIP-1β, tumor necrosis factor [TNF]-α, interleukin [IL]-1β, IL-6, IL-8, IL-17α, granulocyte colony stimulating factor [G-CSF], IL-7, IL-4, IL-5, IL-10, and IL-13) were measured using a multiplex bead-based immunoassay and that of fetal fibronectin (fFN) was measured using enzyme-linked immunosorbent assay (ELISA). Statistical analyses were performed using Student's t-test, Mann-Whitney U test, Pearson's correlation, and receiver operating characteristic (ROC) curve analysis in SPSS version 20.0. Among the 13 cytokines assessed, the levels of 3 cytokines (MIP-1α, IL-6, and IL-7) were negatively correlated with gestational age at delivery (P=0.028, P=0.002, and P=0.018, respectively). Sensitivities of MIP-1α, IL-6, and IL-17α were 70%, 80%, and 75%, respectively, and their specificities were 57%, 65%, and 69%, respectively. The sensitivity and specificity of fFN were 33% and 95%, respectively. In symptomatic women diagnosed with PTL and/or pPROM, cytokines from cervicovaginal fluid, especially IL-6 and IL-17α, could be better predictive markers of PTB than fFN.
Identifiants
pubmed: 32550740
pii: ogs.19131
doi: 10.5468/ogs.19131
pmc: PMC7393743
doi:
Types de publication
Journal Article
Langues
eng
Pagination
455-463Subventions
Organisme : Ministry of Health and Welfare
ID : HI18C0378
Organisme : Korea Health Industry Development Institute
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