A
Administration, Oral
Animals
Animals, Genetically Modified
Antineoplastic Agents
/ administration & dosage
Cell Proliferation
/ drug effects
DNA-Binding Proteins
/ administration & dosage
Disease Models, Animal
Drosophila Proteins
/ genetics
Drosophila melanogaster
/ drug effects
Drug Development
Drug Screening Assays, Antitumor
Female
Gene Expression Regulation, Neoplastic
Humans
Intestinal Neoplasms
/ drug therapy
Neoplastic Stem Cells
/ drug effects
Nuclear Proteins
/ genetics
PC-3 Cells
Peptide Fragments
/ administration & dosage
Signal Transduction
Trans-Activators
/ genetics
Transcription Factors
/ administration & dosage
YAP-Signaling Proteins
Drosophila
Integrin signaling
Intestinal stem cells
Peptide therapeutic
Yki
Journal
Disease models & mechanisms
ISSN: 1754-8411
Titre abrégé: Dis Model Mech
Pays: England
ID NLM: 101483332
Informations de publication
Date de publication:
23 07 2020
23 07 2020
Historique:
received:
17
02
2020
accepted:
27
05
2020
pubmed:
17
6
2020
medline:
24
8
2021
entrez:
17
6
2020
Statut:
epublish
Résumé
Peptide therapeutics, unlike small-molecule drugs, display crucial advantages of target specificity and the ability to block large interacting interfaces, such as those of transcription factors. The transcription co-factor of the Hippo pathway, YAP/Yorkie (Yki), has been implicated in many cancers, and is dependent on its interaction with the DNA-binding TEAD/Sd proteins via a large Ω-loop. In addition, the mammalian vestigial-like (VGLL) proteins, specifically their TONDU domain, competitively inhibit YAP-TEAD interaction, resulting in arrest of tumor growth. Here, we show that overexpression of the TONDU peptide or its oral uptake leads to suppression of Yki-driven intestinal stem cell tumors in the adult
Identifiants
pubmed: 32540914
pii: dmm.044420
doi: 10.1242/dmm.044420
pmc: PMC7390633
pii:
doi:
Substances chimiques
Antineoplastic Agents
0
DNA-Binding Proteins
0
Drosophila Proteins
0
Nuclear Proteins
0
Peptide Fragments
0
Trans-Activators
0
Transcription Factors
0
VGLL1 protein, human
0
YAP-Signaling Proteins
0
Yki protein, Drosophila
0
esg protein, Drosophila
0
sd protein, Drosophila
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Wellcome Trust DBT India Alliance
ID : IA/E/13/1/501271
Pays : International
Organisme : Howard Hughes Medical Institute
Pays : United States
Informations de copyright
© 2020. Published by The Company of Biologists Ltd.
Déclaration de conflit d'intérêts
Competing interestsThe authors declare no competing or financial interests.
Références
Cancers (Basel). 2018 Mar 20;10(3):
pubmed: 29558384
Cell Stem Cell. 2020 May 7;26(5):675-692.e8
pubmed: 32259481
Dev Cell. 2015 Apr 6;33(1):36-46
pubmed: 25850671
Proc Natl Acad Sci U S A. 2014 Mar 25;111(12):4530-5
pubmed: 24616500
Recent Pat Anticancer Drug Discov. 2017;12(2):148-168
pubmed: 28164756
Cell Metab. 2018 May 01;27(5):1040-1054.e8
pubmed: 29606597
Trends Cancer. 2015 Sep 1;1(1):53-65
pubmed: 26645049
Cell Rep. 2013 Feb 21;3(2):309-18
pubmed: 23395637
Proc Natl Acad Sci U S A. 2013 Sep 3;110(36):E3445-54
pubmed: 23946421
Cell Res. 2014 Mar;24(3):331-43
pubmed: 24458094
Cancer Cell. 2019 Mar 18;35(3):347-367
pubmed: 30889378
J Med Chem. 2018 Jun 28;61(12):5057-5072
pubmed: 29251924
Int J Pharm. 2013 Apr 15;447(1-2):75-93
pubmed: 23428883
Cell. 1986 Aug 15;46(4):575-82
pubmed: 3015419
Proc Natl Acad Sci U S A. 2011 Dec 6;108(49):E1312-20
pubmed: 22042863
Cancer Biol Ther. 2013 May;14(5):390-8
pubmed: 23380592
J Biol Chem. 2000 Oct 6;275(40):30801-5
pubmed: 10934189
Cancer Cell. 2017 Apr 10;31(4):532-548.e7
pubmed: 28344039
Nat Genet. 2002 Apr;30(4):367-76
pubmed: 11925563
J Cell Sci. 2009 Jul 15;122(Pt 14):2543-53
pubmed: 19549687
Genes Dev. 2012 Sep 15;26(18):2027-37
pubmed: 22925885
Nature. 2009 Jan 29;457(7229):608-11
pubmed: 19092804
Structure. 2012 Jul 3;20(7):1135-40
pubmed: 22632831
Proc Natl Acad Sci U S A. 2013 Jun 11;110(24):E2163-72
pubmed: 23708122
Cell Rep. 2016 Sep 13;16(11):3062-3074
pubmed: 27626673
Proc Natl Acad Sci U S A. 2012 Jan 10;109(2):370-7
pubmed: 22203956
Bioorg Med Chem. 2018 Jun 1;26(10):2700-2707
pubmed: 28720325
J Biol Chem. 1997 Jun 20;272(25):16010-7
pubmed: 9188504
Nature. 2013 Jan 3;493(7430):106-10
pubmed: 23178811
Molecules. 2018 Jun 19;23(6):
pubmed: 29921764
Cancer Cell. 2014 Feb 10;25(2):166-80
pubmed: 24525233
PLoS Biol. 2018 Oct 19;16(10):e3000041
pubmed: 30339698
Bioorg Med Chem Lett. 2019 Aug 15;29(16):2316-2319
pubmed: 31235263
Dev Biol. 2013 May 1;377(1):177-87
pubmed: 23410794
Br J Cancer. 2020 Jan;122(1):4-22
pubmed: 31819192
J Biol Chem. 2007 Mar 23;282(12):8969-77
pubmed: 17227774
Cell Rep. 2012 Jan 26;1(1):13-20
pubmed: 22832104
Theranostics. 2020 Feb 18;10(8):3622-3635
pubmed: 32206112
Development. 1999 Nov;126(22):5161-9
pubmed: 10529432
Dev Biol. 2020 Jan 1;457(1):1-8
pubmed: 31557471
Nat Commun. 2016 Nov 29;7:13615
pubmed: 27897178
Dis Model Mech. 2013 May;6(3):661-78
pubmed: 23324326
Dev Cell. 2019 Jan 28;48(2):277-286.e6
pubmed: 30639055
Cancer Metastasis Rev. 2012 Dec;31(3-4):689-98
pubmed: 22706846
Oncogene. 2009 Apr 30;28(17):1916-27
pubmed: 19330023
Dev Cell. 2008 Mar;14(3):388-98
pubmed: 18258486
Nat Med. 2013 May;19(5):619-25
pubmed: 23584089
Elife. 2014 Apr 22;3:e02181
pubmed: 24755291
Nucleic Acids Res. 2019 Jan 8;47(D1):D607-D613
pubmed: 30476243
Cancer Cell. 2016 Jun 13;29(6):783-803
pubmed: 27300434
Am J Cancer Res. 2018 Jun 01;8(6):932-943
pubmed: 30034932
Mol Ther. 2007 Feb;15(2):303-9
pubmed: 17235308
Curr Opin Genet Dev. 2016 Oct;40:81-86
pubmed: 27392294
Nat Rev Drug Discov. 2016 Mar;15(3):173-83
pubmed: 26822833
Science. 2013 Nov 8;342(6159):737-40
pubmed: 24114784
Nucleic Acids Res. 2007 Jan;35(Database issue):D247-52
pubmed: 17130144
Nat Rev Drug Discov. 2020 Apr;19(4):277-289
pubmed: 31848464
Development. 1993 Jun;118(2):401-15
pubmed: 8223268
Cell Res. 2013 Oct;23(10):1201-14
pubmed: 23999857
Nature. 2012 Jun 06;486(7401):80-4
pubmed: 22678283
Elife. 2013 Oct 15;2:e00999
pubmed: 24137538
Adv Drug Deliv Rev. 2005 Feb 28;57(4):579-96
pubmed: 15722165
Curr Biol. 2007 Dec 4;17(23):2054-60
pubmed: 17980593
Cells. 2019 Jun 17;8(6):
pubmed: 31212916
Chem Biol. 2011 Aug 26;18(8):1000-10
pubmed: 21867915
Dev Cell. 2013 May 28;25(4):388-401
pubmed: 23725764
Anal Bioanal Chem. 2007 Oct;389(4):1017-31
pubmed: 17668192