Aggressive multiple sclerosis (2): Treatment.
Aggressive
disability
highly active
multiple sclerosis
relapsing–remitting
treatment response
Journal
Multiple sclerosis (Houndmills, Basingstoke, England)
ISSN: 1477-0970
Titre abrégé: Mult Scler
Pays: England
ID NLM: 9509185
Informations de publication
Date de publication:
12 06 2020
12 06 2020
Historique:
entrez:
13
6
2020
pubmed:
13
6
2020
medline:
13
6
2020
Statut:
aheadofprint
Résumé
The natural history of multiple sclerosis (MS) is highly heterogeneous. A subgroup of patients has what might be termed aggressive MS. These patients may have frequent, severe relapses with incomplete recovery and are at risk of developing greater and permanent disability at the earlier stages of the disease. Their therapeutic window of opportunity may be narrow, and while it is generally considered that they will benefit from starting early with a highly efficacious treatment, a unified definition of aggressive MS does not exist and data on its treatment are largely lacking. Based on discussions at an international focused workshop sponsored by the European Committee for Treatment and Research in Multiple Sclerosis (ECTRIMS), we review our current knowledge about treatment of individuals with aggressive MS. We analyse the available evidence, identify gaps in knowledge and suggest future research needed to fill those gaps. A companion paper details the difficulties in developing a consensus about what defines aggressive MS.
Identifiants
pubmed: 32530366
doi: 10.1177/1352458520924595
pmc: PMC7412878
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
1352458520924595Investigateurs
Maria Pia Amato
(MP)
Georgina Arrambide
(G)
Joseph Berger
(J)
Alexey Boyko
(A)
Vesna Brinar
(V)
Wallace Brownlee
(W)
Lou Brundin
(L)
Olga Ciccarelli
(O)
Alasdair Coles
(A)
Jorge Correale
(J)
Gary Cutter
(G)
Tobias Derfuss
(T)
Gilles Edan
(G)
Nikolaos Evangelou
(N)
Oscar Fernandez
(O)
Jette Frederiksen
(J)
Ralf Gold
(R)
Yael Hacohen
(Y)
Hans-Peter Hartung
(HP)
Kerstin Hellwig
(K)
Bernhard Hemmer
(B)
Jan Hillert
(J)
Ellen Iacobaeus
(E)
Jaime Imitola
(J)
Tomas Kalincik
(T)
Ludwig Kappos
(L)
Samia Khoury
(S)
Ho Jin Kim
(HJ)
Eva Kubala Havrdová
(E)
Roland Liblau
(R)
Jan Lycke
(J)
Xavier Montalban
(X)
Paolo Muraro
(P)
Stephen Reingold
(S)
Klaus Schmierer
(K)
Finn Sellebjerg
(F)
Per Soelberg Sørensen
(P)
Alessandra Solari
(A)
Maria Pia Sormani
(MP)
Alan Thompson
(A)
Mar Tintore
(M)
Bruce Trapp
(B)
Helen Tremlett
(H)
Maria Trojano
(M)
Carmen Tur
(C)
Antonio Uccelli
(A)
Vincent van Pesch
(V)
Sandra Vukusic
(S)
Emmanuelle Waubant
(E)
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