A Longitudinal Skin Biopsy Study of Phosphorylated Alpha-Synuclein in a Patient With Parkinson Disease and Orthostatic Hypotension.
Multiple system atrophy
Orthostatic hypotension
Parkinson disease
Skin biopsy
α-Synuclein
Journal
Journal of neuropathology and experimental neurology
ISSN: 1554-6578
Titre abrégé: J Neuropathol Exp Neurol
Pays: England
ID NLM: 2985192R
Informations de publication
Date de publication:
01 07 2020
01 07 2020
Historique:
received:
26
06
2019
revised:
24
07
2019
accepted:
12
05
2020
pubmed:
13
6
2020
medline:
1
12
2020
entrez:
13
6
2020
Statut:
ppublish
Résumé
The aim of our study was to assess the distribution of phosphorylated α-synuclein (p-syn) deposits in a patient affected by early stage Parkinson disease and orthostatic hypotension through a longitudinal skin biopsy study. We found widespread p-syn spatial diffusion from deep autonomic dermis nerve bundles to autonomic terminals, suggesting a centrifugal spread of p-syn from ganglia to the innervation target structures. Furthermore, the case suggests the possibility of discriminating synucleinopathies at an early stage of disease by means of skin biopsy. If confirmed, these data support skin biopsy as a useful and promising tool for the diagnosis, longitudinal evaluation, and pathological understanding of Parkinson disease.
Identifiants
pubmed: 32529258
pii: 5856234
doi: 10.1093/jnen/nlaa048
doi:
Substances chimiques
alpha-Synuclein
0
Types de publication
Case Reports
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
813-816Informations de copyright
© 2020 American Association of Neuropathologists, Inc. All rights reserved.