Molecular mechanisms of thalidomide and its derivatives.
cereblon
immunomodulatory imide drugs (IMiDs)
lenalidomide
proteolysis targeting chimeras (PROTACs)
thalidomide
ubiquitin
Journal
Proceedings of the Japan Academy. Series B, Physical and biological sciences
ISSN: 1349-2896
Titre abrégé: Proc Jpn Acad Ser B Phys Biol Sci
Pays: Japan
ID NLM: 9318162
Informations de publication
Date de publication:
2020
2020
Historique:
entrez:
12
6
2020
pubmed:
12
6
2020
medline:
7
4
2021
Statut:
ppublish
Résumé
Thalidomide, originally developed as a sedative drug, causes multiple defects due to severe teratogenicity, but it has been re-purposed for treating multiple myeloma, and derivatives such as lenalidomide and pomalidomide have been developed for treating blood cancers. Although the molecular mechanisms of thalidomide and its derivatives remained poorly understood until recently, we identified cereblon (CRBN), a primary direct target of thalidomide, using ferrite glycidyl methacrylate (FG) beads. CRBN is a ligand-dependent substrate receptor of the E3 ubiquitin ligase complex cullin-RING ligase 4 (CRL4
Identifiants
pubmed: 32522938
doi: 10.2183/pjab.96.016
pmc: PMC7298168
doi:
Substances chimiques
Thalidomide
4Z8R6ORS6L
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
189-203Références
Mol Cell. 2006 Sep 1;23(5):709-21
pubmed: 16949367
N Engl J Med. 1992 Apr 16;326(16):1055-8
pubmed: 1549151
EMBO J. 1988 Apr;7(4):1175-82
pubmed: 2841115
N Engl J Med. 2005 Feb 10;352(6):549-57
pubmed: 15703420
Nat Chem Biol. 2019 Nov;15(11):1077-1084
pubmed: 31591562
Mol Pharmacol. 2008 Mar;73(3):987-94
pubmed: 18089836
J Biol Chem. 1995 May 26;270(21):12335-8
pubmed: 7759473
Genes Dev. 2009 May 1;23(9):1106-18
pubmed: 19417105
Nature. 2014 Aug 7;512(7512):49-53
pubmed: 25043012
Hum Mol Genet. 2002 Nov 1;11(23):2979-87
pubmed: 12393809
ACS Omega. 2018 Sep 14;3(9):11163-11171
pubmed: 31459225
Cell. 2006 Jan 13;124(1):105-17
pubmed: 16413485
Birth Defects Res C Embryo Today. 2015 Jun;105(2):140-56
pubmed: 26043938
Annu Rev Plant Biol. 2008;59:467-89
pubmed: 18444905
Nat Commun. 2016 Mar 18;7:11030
pubmed: 26988023
Cell. 1999 Apr 2;97(1):41-51
pubmed: 10199401
Neurology. 2004 Nov 23;63(10):1927-31
pubmed: 15557513
Arthritis Rheum. 1984 Oct;27(10):1118-21
pubmed: 6237660
Br J Haematol. 2011 Aug;154(3):325-36
pubmed: 21707574
Proc Natl Acad Sci U S A. 1994 Apr 26;91(9):4082-5
pubmed: 7513432
Lancet. 2004 May 29;363(9423):1802-11
pubmed: 15172781
J Exp Med. 1993 Jun 1;177(6):1675-80
pubmed: 8496685
N Engl J Med. 2007 Nov 22;357(21):2123-32
pubmed: 18032762
Development. 2007 Jan;134(2):295-305
pubmed: 17166920
Science. 1986 Oct 3;234(4772):47-52
pubmed: 3529394
Nat Rev Drug Discov. 2017 Feb;16(2):101-114
pubmed: 27885283
J Med Genet. 2017 Apr;54(4):236-240
pubmed: 28143899
Toxicol Sci. 2009 May;109(1):143-51
pubmed: 19240039
Blood. 2015 Aug 6;126(6):779-89
pubmed: 26002965
Bone Marrow Transplant. 1988 Sep;3(5):393-8
pubmed: 3056547
Mol Cell. 2017 Jul 6;67(1):5-18.e19
pubmed: 28673542
Genes Cells. 2010 Apr 1;15(4):339-49
pubmed: 20298436
Bioorg Med Chem Lett. 1999 Jun 7;9(11):1625-30
pubmed: 10386948
Mol Cell. 2007 Jun 22;26(6):775-80
pubmed: 17588513
Cell. 2005 May 6;121(3):387-400
pubmed: 15882621
Nat Rev Genet. 2007 May;8(5):353-67
pubmed: 17440532
Nature. 1999 Apr 22;398(6729):708-13
pubmed: 10227293
Mol Pharmacol. 2013 Mar;83(3):613-20
pubmed: 23229512
Proc Natl Acad Sci U S A. 2013 Apr 30;110(18):7300-5
pubmed: 23589895
Expert Rev Clin Immunol. 2017 Aug;13(8):799-814
pubmed: 28471259
Chem Commun (Camb). 2017 Jul 4;53(54):7577-7580
pubmed: 28636052
N Engl J Med. 2018 Sep 6;379(10):934-947
pubmed: 30184451
Leukemia. 2012 Nov;26(11):2326-35
pubmed: 22552008
DNA Repair (Amst). 2003 Sep 18;2(9):1065-9
pubmed: 12967661
Int J Biochem Cell Biol. 2007;39(7-8):1489-99
pubmed: 17369076
Blood. 2020 Mar 26;135(13):996-1007
pubmed: 31977002
Clin Ther. 1999 Feb;21(2):319-30
pubmed: 10211535
Blood. 2009 Nov 19;114(21):4713-20
pubmed: 19786615
Cell. 2004 Jan 23;116(2):181-90
pubmed: 14744430
J Biol Chem. 2006 Oct 20;281(42):31729-35
pubmed: 16920706
Science. 2014 Jan 17;343(6168):301-5
pubmed: 24292625
Nat Biotechnol. 2000 Aug;18(8):877-81
pubmed: 10932159
Am J Hum Genet. 2002 Nov;71(5):1195-9
pubmed: 12395297
Int J Biochem Cell Biol. 2011 Dec;43(12):1664-7
pubmed: 21959250
Angew Chem Int Ed Engl. 2016 Jan 11;55(2):807-10
pubmed: 26593377
Nat Genet. 2000 Dec;26(4):460-3
pubmed: 11101846
Stem Cells. 2011 Nov;29(11):1672-83
pubmed: 21898690
Leuk Lymphoma. 2017 Aug;58(8):1999-2001
pubmed: 28093007
Cell Chem Biol. 2020 Jan 16;27(1):19-31.e6
pubmed: 31883964
Br J Haematol. 2014 Mar;164(6):811-21
pubmed: 24328678
ACS Chem Biol. 2018 Mar 16;13(3):553-560
pubmed: 29356495
Nat Rev Cancer. 2004 Apr;4(4):314-22
pubmed: 15057291
Blood. 2011 Nov 3;118(18):4771-9
pubmed: 21860026
Dev Dyn. 2002 Oct;225(2):186-94
pubmed: 12242718
J Exp Med. 1991 Mar 1;173(3):699-703
pubmed: 1997652
Nature. 2016 Jun 22;535(7611):252-7
pubmed: 27338790
PLoS One. 2012;7(12):e50481
pubmed: 23227178
Bioessays. 2009 Dec;31(12):1327-36
pubmed: 19921660
Nat Med. 2016 Jul;22(7):735-43
pubmed: 27294876
Nat Chem Biol. 2019 Oct;15(10):937-944
pubmed: 31527835
Nature. 2006 Oct 5;443(7111):590-3
pubmed: 16964240
Blood. 2018 Sep 20;132(12):1293-1303
pubmed: 30042095
Elife. 2018 Aug 01;7:
pubmed: 30067223
Nat Commun. 2019 Aug 1;10(1):3468
pubmed: 31371704
Trends Genet. 2002 Feb;18(2):90-5
pubmed: 11818141
Cell. 2003 May 2;113(3):357-67
pubmed: 12732143
N Engl J Med. 2006 Oct 5;355(14):1456-65
pubmed: 17021321
Nat Rev Genet. 2012 Oct;13(10):720-31
pubmed: 22986266
Proc Natl Acad Sci U S A. 2001 Jul 17;98(15):8554-9
pubmed: 11438690
Nat Chem Biol. 2018 Feb;14(2):163-170
pubmed: 29251720
Blood. 2018 Oct 4;132(14):1535-1544
pubmed: 30064974
Drug Discov Today Technol. 2019 Apr;31:29-34
pubmed: 31200856
Genes Dev. 1998 Feb 1;12(3):343-56
pubmed: 9450929
Nature. 2015 Jul 9;523(7559):183-188
pubmed: 26131937
Nat Chem Biol. 2015 Sep;11(9):634-5
pubmed: 26284668
Nature. 2015 Jul 9;523(7559):167-8
pubmed: 26131932
N Engl J Med. 1999 Nov 18;341(21):1565-71
pubmed: 10564685
Sci Rep. 2018 Jan 22;8(1):1294
pubmed: 29358579
Cell. 2008 Dec 26;135(7):1213-23
pubmed: 19109893
Nat Genet. 2000 Dec;26(4):455-9
pubmed: 11101845
Clin Cancer Res. 2019 Jan 1;25(1):90-98
pubmed: 30201761
Nature. 2016 Apr 7;532(7597):127-30
pubmed: 26909574
Bioorg Med Chem. 2012 Mar 15;20(6):1990-2001
pubmed: 22264760
Birth Defects Res A Clin Mol Teratol. 2004 Aug;70(8):550-1
pubmed: 15329836
Mol Cell. 2006 Jan 20;21(2):227-37
pubmed: 16427012
Cell Host Microbe. 2007 Dec 13;2(6):383-92
pubmed: 18078690
Proc Natl Acad Sci U S A. 2018 Nov 13;115(46):11802-11807
pubmed: 30373817
Mol Pharmacol. 2006 Nov;70(5):1832-9
pubmed: 16936229
Ann Rheum Dis. 2018 Oct;77(10):1516-1523
pubmed: 29945920
ACS Med Chem Lett. 2019 Nov 12;10(12):1592-1602
pubmed: 31857833
Drug Saf. 2010 Jan 1;33(1):35-45
pubmed: 20000865
Chem Pharm Bull (Tokyo). 1994 May;42(5):1157-9
pubmed: 8069968
Elife. 2018 Sep 20;7:
pubmed: 30234487
Am J Med Genet A. 2006 Jul 1;140(13):1396-406
pubmed: 16691622
Mol Cell Biol. 2013 Jun;33(12):2497-507
pubmed: 23589332
Teratology. 1977 Aug;16(1):79-82
pubmed: 331548
Colloids Surf B Biointerfaces. 2008 Jul 15;64(2):162-9
pubmed: 18313904
Ann Oncol. 2015 Sep;26 Suppl 5:v116-25
pubmed: 26314773
PLoS One. 2008 Aug 27;3(8):e3070
pubmed: 18728780
J Med Chem. 2018 Jan 25;61(2):535-542
pubmed: 28425720
Science. 2014 Jan 17;343(6168):305-9
pubmed: 24292623
Pharmacol Ther. 2019 Oct;202:132-139
pubmed: 31202702
Nat Struct Mol Biol. 2014 Sep;21(9):803-9
pubmed: 25108355
Nat Rev Mol Cell Biol. 2005 Jan;6(1):9-20
pubmed: 15688063
Genes Dev. 1995 Mar 1;9(5):559-72
pubmed: 7698646
J Med Chem. 2018 Jan 25;61(2):482-491
pubmed: 28379698
Clin Pharmacol Ther. 1965 May-Jun;6:303-6
pubmed: 14296027
Nat Chem Biol. 2018 Oct;14(10):981-987
pubmed: 30190590
Br J Haematol. 2009 May;145(3):344-9
pubmed: 19245430
Elife. 2019 Mar 25;8:
pubmed: 30907729
J Med Chem. 2018 Jan 25;61(2):492-503
pubmed: 28358507
Science. 2015 Jun 19;348(6241):1376-81
pubmed: 25999370
Science. 2010 Mar 12;327(5971):1345-50
pubmed: 20223979
N Engl J Med. 2015 Nov 5;373(19):1835-44
pubmed: 26535512
Biochim Biophys Acta Proteins Proteom. 2019 Jan;1867(1):22-27
pubmed: 30392561
Leukemia. 2020 Apr;34(4):1197-1201
pubmed: 31719682
J Struct Biol. 2014 Dec;188(3):225-32
pubmed: 25448889
Science. 2018 Nov 2;362(6414):
pubmed: 30385546
Nat Commun. 2017 May 22;8:15398
pubmed: 28530236