Draft genome sequence of antimicrobial producing Paenibacillus alvei strain MP1 reveals putative novel antimicrobials.
Antimicrobial-producing strain
NRPS
Paenibacillus alvei
Whole genome sequencing
Journal
BMC research notes
ISSN: 1756-0500
Titre abrégé: BMC Res Notes
Pays: England
ID NLM: 101462768
Informations de publication
Date de publication:
09 Jun 2020
09 Jun 2020
Historique:
received:
16
02
2020
accepted:
04
06
2020
entrez:
11
6
2020
pubmed:
11
6
2020
medline:
6
3
2021
Statut:
epublish
Résumé
A Paenibacillus strain isolated in previous research exhibited antimicrobial activity against relevant human pathogens including Staphylococcus aureus and Listeria monocytogenes. In this study, the genome of the aforementioned strain, designated as MP1, was shotgun sequenced. The draft genome of strain MP1 was subject to multiple genomic analyses to taxonomically characterize it and identify the genes potentially responsible for its antimicrobial activity. Here we report the draft genome sequence of an antimicrobial producing Paenibacillus strain, MP1. Average Nucleotide Identity (ANI) analysis established strain MP1 as a new strain of the previously characterized Paenibacillus alvei. The genomic analysis identified several putative secondary metabolite clusters including seven Nonribosomal Peptide Synthetase clusters (NRPS) (> 10,000 nt), one bacteriocin or other unspecified Ribosomally Synthesized and Post-Translationally modified Peptide Product (RiPP), one lanthipeptide, and six hybrid clusters (NRPS-Type I Polyketide synthase (T1PKS) and NRPS-trans Amino Transferase Polyketide Synthase (AT-PKS)).
Identifiants
pubmed: 32517793
doi: 10.1186/s13104-020-05124-z
pii: 10.1186/s13104-020-05124-z
pmc: PMC7285544
doi:
Substances chimiques
Anti-Infective Agents
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
280Subventions
Organisme : Narodowe Centrum Nauki
ID : 2015/18/E/NZ6/00700
Organisme : College of Agriculture and Life Sciences, Cornell University
ID : S1077 Multi-state grant
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