Saliva Pepsin Concentration of Laryngopharyngeal Reflux Patients Is Influenced by Meals Consumed Before the Samples.
Adult
Aged
Diet
/ adverse effects
Diet Surveys
Electric Impedance
Esophageal pH Monitoring
Female
Humans
Laryngopharyngeal Reflux
/ drug therapy
Male
Meals
/ physiology
Middle Aged
Pepsin A
/ metabolism
Prospective Studies
Proton Pump Inhibitors
/ therapeutic use
Saliva
/ chemistry
Severity of Illness Index
Young Adult
Reflux
beverages
diet
foods
laryngitis
laryngopharyngeal
pepsin
saliva
Journal
The Laryngoscope
ISSN: 1531-4995
Titre abrégé: Laryngoscope
Pays: United States
ID NLM: 8607378
Informations de publication
Date de publication:
02 2021
02 2021
Historique:
received:
11
02
2020
revised:
06
04
2020
accepted:
28
04
2020
pubmed:
9
6
2020
medline:
20
1
2021
entrez:
9
6
2020
Statut:
ppublish
Résumé
To assess the impact of diet on the saliva pepsin concentration of patients with laryngopharyngeal reflux (LPR). Non-controlled Prospective Study. Patients with positive LPR regarding hypopharyngeal-esophageal impedance-pH monitoring (HEMII-pH) were enrolled from three European Hospitals. Patients collected three saliva samples, respectively, in the morning (fasting), and 1 to 2 hour after lunch and dinner. Patients carefully detailed foods and beverages consumed during meals and before the pepsin samples. The 3-month treatment was based on the association of diet, proton pump inhibitors, alginate, or magaldrate regarding the HEMII-pH characteristics. Reflux Symptom Score (RSS) and Reflux Sign Assessment (RSA) were used for assessing the pre- to posttreatment clinical evolution. The Refluxogenic Diet Score and the Refluxogenic Score of a Dish (RESDI) were used to assess the refluxogenic potential of foods and beverages. The relationship between saliva pepsin concentration, HEMII-pH, RESDI, RSS, and RSA was investigated through multiple linear regression. Forty-two patients were included. The saliva pepsin concentration of the 24-hour period of testing was significantly associated with foods and beverages consumed during the testing period and the evening dinner (r Foods and beverages may significantly impact the saliva pepsin concentration of patients with LPR. Patients with high-level saliva pepsin in the morning had lower therapeutic response compared with those with low-level saliva pepsin. 4 Laryngoscope, 131:350-359, 2021.
Substances chimiques
Proton Pump Inhibitors
0
Pepsin A
EC 3.4.23.1
Types de publication
Evaluation Study
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
350-359Subventions
Organisme : IRIS Grant
ID : 2018
Pays : International
Organisme : VESALE GRANT 2017
ID : 2017
Pays : International
Informations de copyright
© 2020 The American Laryngological, Rhinological and Otological Society, Inc.
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