Eosinophilic Esophagitis: Existing and Upcoming Therapies in an Age of Emerging Molecular and Personalized Medicine.
Diagnosis
Endotype
Eosinophilic esophagitis
Treatment
Journal
Current allergy and asthma reports
ISSN: 1534-6315
Titre abrégé: Curr Allergy Asthma Rep
Pays: United States
ID NLM: 101096440
Informations de publication
Date de publication:
06 06 2020
06 06 2020
Historique:
entrez:
8
6
2020
pubmed:
9
6
2020
medline:
9
2
2021
Statut:
epublish
Résumé
Recent research efforts have spurred great progress in the diagnosis and management of eosinophilic esophagitis (EoE). Nonetheless, challenges remain in addressing disease burden and impairment in the growing EoE population. We highlight work from the Cincinnati Center for Eosinophilic Disorders, the Consortium of Eosinophilic Gastrointestinal Disease Researchers, and others that address these ongoing challenges. New tools for characterizing EoE disease activity include the EoE Histology Scoring System (EoEHSS), endoscopic alternatives, validated patient-reported outcome (PRO) questionnaires, and investigational biomarkers. These diagnostic and monitoring strategies have been complemented by advances in EoE therapy. Treatment modalities have refined the traditional approaches of dietary elimination, swallowed steroids, and proton pump inhibitors (PPI), and biologics offer promise for future treatment. This review summarizes EoE advances in disease management and newly defined EoE endotypes that may serve as the foundation for EoE-personalized medicine.
Identifiants
pubmed: 32506181
doi: 10.1007/s11882-020-00928-2
pii: 10.1007/s11882-020-00928-2
pmc: PMC8034809
mid: NIHMS1685915
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
30Subventions
Organisme : NIAID NIH HHS
ID : U54 AI117804
Pays : United States
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