ENIGMA MDD: seven years of global neuroimaging studies of major depression through worldwide data sharing.

Brain / diagnostic imaging Depression Depressive Disorder, Major / diagnostic imaging Humans Information Dissemination Neuroimaging

Journal

Translational psychiatry
ISSN: 2158-3188
Titre abrégé: Transl Psychiatry
Pays: United States
ID NLM: 101562664

Informations de publication

Date de publication:
29 05 2020
Historique:
received: 11 10 2019
accepted: 07 05 2020
revised: 09 04 2020
entrez: 31 5 2020
pubmed: 31 5 2020
medline: 22 6 2021
Statut: epublish

Résumé

A key objective in the field of translational psychiatry over the past few decades has been to identify the brain correlates of major depressive disorder (MDD). Identifying measurable indicators of brain processes associated with MDD could facilitate the detection of individuals at risk, and the development of novel treatments, the monitoring of treatment effects, and predicting who might benefit most from treatments that target specific brain mechanisms. However, despite intensive neuroimaging research towards this effort, underpowered studies and a lack of reproducible findings have hindered progress. Here, we discuss the work of the ENIGMA Major Depressive Disorder (MDD) Consortium, which was established to address issues of poor replication, unreliable results, and overestimation of effect sizes in previous studies. The ENIGMA MDD Consortium currently includes data from 45 MDD study cohorts from 14 countries across six continents. The primary aim of ENIGMA MDD is to identify structural and functional brain alterations associated with MDD that can be reliably detected and replicated across cohorts worldwide. A secondary goal is to investigate how demographic, genetic, clinical, psychological, and environmental factors affect these associations. In this review, we summarize findings of the ENIGMA MDD disease working group to date and discuss future directions. We also highlight the challenges and benefits of large-scale data sharing for mental health research.

Identifiants

DOI: 10.1038/s41398-020-0842-6 PMID: 32472038 PMC: PMC7260219
pubmed: 32472038
doi: 10.1038/s41398-020-0842-6
pii: 10.1038/s41398-020-0842-6
pmc: PMC7260219
doi:

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Review

Langues

eng

Sous-ensembles de citation

IM

Pagination

172

Subventions

Organisme : NIMH NIH HHS
ID : R37 MH101495
Pays : United States
Organisme : NCRR NIH HHS
ID : P41 RR008079
Pays : United States
Organisme : Medical Research Council
ID : MR/L010305/1
Pays : United Kingdom
Organisme : NIMH NIH HHS
ID : R01 MH116147
Pays : United States
Organisme : Wellcome Trust
Pays : United Kingdom
Organisme : NCCIH NIH HHS
ID : R61 AT009864
Pays : United States
Organisme : NIMH NIH HHS
ID : K01 MH117442
Pays : United States
Organisme : NIMH NIH HHS
ID : R01 MH085734
Pays : United States
Organisme : NIBIB NIH HHS
ID : U54 EB020403
Pays : United States
Organisme : NIMH NIH HHS
ID : R01 MH117601
Pays : United States
Organisme : NIMH NIH HHS
ID : K23 MH090421
Pays : United States
Organisme : Department of Health | National Health and Medical Research Council (NHMRC)
ID : 1140764
Pays : International

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Auteurs

Lianne Schmaal (L)

Orygen, The National Centre of Excellence in Youth Mental Health, Parkville, VIC, Australia. lianne.schmaal@unimelb.edu.au.
Centre for Youth Mental Health, The University of Melbourne, Parkville, VIC, Australia. lianne.schmaal@unimelb.edu.au.
ORCID: 0000-0001-9822-048X

Elena Pozzi (E)

Orygen, The National Centre of Excellence in Youth Mental Health, Parkville, VIC, Australia.
Centre for Youth Mental Health, The University of Melbourne, Parkville, VIC, Australia.

Tiffany C Ho (T)

Department of Psychology, Stanford University, Stanford, CA, USA.
Department of Psychiatry & Behavioral Sciences, Stanford University, Stanford, CA, USA.
Department of Psychiatry & Weill Institute for Neurosciences, University of California, San Francisco, CA, USA.

Laura S van Velzen (LS)

Orygen, The National Centre of Excellence in Youth Mental Health, Parkville, VIC, Australia.
Centre for Youth Mental Health, The University of Melbourne, Parkville, VIC, Australia.

Ilya M Veer (IM)

Division of Mind and Brain Research, Department of Psychiatry and Psychotherapy CCM, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin, Germany.

Nils Opel (N)

Department of Psychiatry, University of Münster, Münster, Germany.

Eus J W Van Someren (EJW)

Department of Sleep and Cognition, Netherlands Institute for Neuroscience (NIN), an institute of the Royal Netherlands Academy of Arts and Sciences, Amsterdam, Netherlands.
Department of Integrative Neurophysiology, Center for Neurogenomics and Cognitive Research (CNCR), Amsterdam Neuroscience, VU University Amsterdam, Amsterdam, The Netherlands.
Department of Psychiatry, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam Neuroscience, Amsterdam Public Health Research Institute, Amsterdam, The Netherlands.

Laura K M Han (LKM)

Department of Psychiatry, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam Neuroscience, Amsterdam Public Health Research Institute, Amsterdam, The Netherlands.
ORCID: 0000-0001-9647-3723

Lybomir Aftanas (L)

FSSBI Scientific Research Institute of Physiology & Basic Medicine, Laboratory of Affective, Cognitive & Translational Neuroscience, Novosibirsk, Russia.
Department of Neuroscience, Novosibirsk State University, Novosibirsk, Russia.

André Aleman (A)

Department of Biomedical Sciences of Cells and Systems, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.

Bernhard T Baune (BT)

Department of Psychiatry, University of Münster, Münster, Germany.
Department of Psychiatry, University of Melbourne, Melbourne, VIC, Australia.
The Florey Institute of Neuroscience and Mental Health, University of Melbourne, Melbourne, VIC, Australia.

Klaus Berger (K)

Institute of Epidemiology and Social Medicine, University of Münster, Münster, Germany.

Tessa F Blanken (TF)

Department of Sleep and Cognition, Netherlands Institute for Neuroscience (NIN), an institute of the Royal Netherlands Academy of Arts and Sciences, Amsterdam, Netherlands.
Department of Integrative Neurophysiology, Center for Neurogenomics and Cognitive Research (CNCR), Amsterdam Neuroscience, VU University Amsterdam, Amsterdam, The Netherlands.

Liliana Capitão (L)

Department of Psychiatry, Oxford University, Oxford, UK.
Oxford Health NHS Foundation Trust, Oxford, UK.
ORCID: 0000-0003-3117-5156

Baptiste Couvy-Duchesne (B)

Institute for Molecular Bioscience, the University of Queensland, Brisbane, QLD, Australia.

Kathryn R Cullen (K)

Department of Psychology, University of Minnesota, Minneapolis, MN, USA.

Udo Dannlowski (U)

Department of Psychiatry, University of Münster, Münster, Germany.

Christopher Davey (C)

Department of Psychiatry, University of Melbourne, Melbourne, VIC, Australia.
ORCID: 0000-0003-1431-3852

Tracy Erwin-Grabner (T)

Laboratory of Systems Neuroscience and Imaging in Psychiatry (SNIP-Lab), University Medical Center Göttingen, Göttingen, Germany.

Jennifer Evans (J)

Experimental Therapeutics Branch, NIMH, NIH, Bethesda, MD, USA.

Thomas Frodl (T)

Department of Psychiatry and Psychotherapy, Jena University Hospital, Jena, Germany.

Cynthia H Y Fu (CHY)

School of Psychology, University of East London, London, UK.
Centre for Affective Disorders, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.

Beata Godlewska (B)

Department of Psychiatry, Oxford University, Oxford, UK.

Ian H Gotlib (IH)

Department of Psychology, Stanford University, Stanford, CA, USA.

Roberto Goya-Maldonado (R)

Laboratory of Systems Neuroscience and Imaging in Psychiatry (SNIP-Lab), University Medical Center Göttingen, Göttingen, Germany.

Hans J Grabe (HJ)

Department of Psychiatry and Psychotherapy, University Medicine Greifswald, Greifswald, Germany.
German Center for Neurodegenerative Diseases (DZNE), Site Rostock/Greifswald, Germany.
ORCID: 0000-0003-3684-4208

Nynke A Groenewold (NA)

Department of Psychiatry & Mental Health, University of Cape Town, Cape Town, South Africa.

Dominik Grotegerd (D)

Department of Psychiatry, University of Münster, Münster, Germany.

Oliver Gruber (O)

Section for Experimental Psychopathology and Neuroimaging, Department of General Psychiatry, Heidelberg University Hospital, Heidelberg, Germany.

Boris A Gutman (BA)

Illinois Institute of Technology, Chicago, IL, USA.

Geoffrey B Hall (GB)

Department of Psychology, Neuroscience & Behaviour, McMaster University, Hamilton, ON, Canada.

Ben J Harrison (BJ)

Melbourne Neuropsychiatry Centre, Department of Psychiatry, The University of Melbourne & Melbourne Health, Melbourne, VIC, Australia.

Sean N Hatton (SN)

Brain and Mind Centre, University of Sydney, Camperdown, NSW, Australia.
ORCID: 0000-0002-9149-8726

Marco Hermesdorf (M)

Institute of Epidemiology and Social Medicine, University of Münster, Münster, Germany.

Ian B Hickie (IB)

Brain and Mind Centre, University of Sydney, Camperdown, NSW, Australia.

Eva Hilland (E)

Clinical Neuroscience Research Group, Department of Psychology, University of Oslo, Oslo, Norway.
Department of Psychiatry, Diakonhjemmet Hospital, Oslo, Norway.
Norwegian Centre for Mental Disorders Research (NORMENT), Institute of Clinical Medicine, University of Oslo, Oslo, Norway.

Benson Irungu (B)

Department of Psychiatry & Behavioral Sciences, The University of Texas Health Science Center at Houston, Houston, TX, USA.

Rune Jonassen (R)

Faculty of Health Sciences, Oslo Metropolitan University, Oslo, Norway.

Sinead Kelly (S)

Beth Israel Deaconess Medical Centre, Harvard Medical School, Boston, MA, USA.

Tilo Kircher (T)

Department of Psychiatry and Psychotherapy, University of Marburg, Marburg, Germany.

Bonnie Klimes-Dougan (B)

Department of Psychology, University of Minnesota, Minneapolis, MN, USA.

Axel Krug (A)

Department of Psychiatry and Psychotherapy, University of Marburg, Marburg, Germany.
ORCID: 0000-0002-0564-2497

Nils Inge Landrø (NI)

Clinical Neuroscience Research Group, Department of Psychology, University of Oslo, Oslo, Norway.
Department of Psychiatry, Diakonhjemmet Hospital, Oslo, Norway.

Jim Lagopoulos (J)

Sunshine Coast Mind and Neuroscience Thompson Institute, University of the Sunshine Coast, Birtinya, QLD, Australia.

Jeanne Leerssen (J)

Department of Sleep and Cognition, Netherlands Institute for Neuroscience (NIN), an institute of the Royal Netherlands Academy of Arts and Sciences, Amsterdam, Netherlands.
Department of Integrative Neurophysiology, Center for Neurogenomics and Cognitive Research (CNCR), Amsterdam Neuroscience, VU University Amsterdam, Amsterdam, The Netherlands.

Meng Li (M)

Department of Psychiatry and Psychotherapy, Jena University Hospital, Jena, Germany.

David E J Linden (DEJ)

Division of Psychological Medicine and Clinical Neurosciences, Cardiff University, Cardiff, UK.
MRC Center for Neuropsychiatric Genetics and Genomics, Cardiff University, Cardiff, UK.
Cardiff University Brain Research Imaging Center, Cardiff University, Cardiff, UK.
ORCID: 0000-0002-5638-9292

Frank P MacMaster (FP)

Psychiatry and Pediatrics, University of Calgary, Addictions and Mental Health Strategic Clinical Network, Calgary, AB, Canada.

Andrew M McIntosh (A)

Centre for Clinical Brain Science, University of Edinburgh, Edinburgh, UK.
ORCID: 0000-0002-0198-4588

David M A Mehler (DMA)

Department of Psychiatry, University of Münster, Münster, Germany.
MRC Center for Neuropsychiatric Genetics and Genomics, Cardiff University, Cardiff, UK.
Cardiff University Brain Research Imaging Center, Cardiff University, Cardiff, UK.

Igor Nenadić (I)

Department of Psychiatry and Psychotherapy, University of Marburg, Marburg, Germany.
Marburg University Hospital UKGM, Marburg, Germany.

Brenda W J H Penninx (BWJH)

Department of Psychiatry, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam Neuroscience, Amsterdam Public Health Research Institute, Amsterdam, The Netherlands.

Maria J Portella (MJ)

Institut d'Investigació Biomèdica-Sant Pau, Barcelona, Spain.
CIBERSAM, Madrid, Spain.
Universitat Autònoma de Barcelona, Barcelona, Spain.

Liesbeth Reneman (L)

Department of Radiology and Nuclear Medicine, location AMC, Amsterdam UMC, Amsterdam, The Netherlands.

Miguel E Rentería (ME)

Department of Genetics & Computational Biology, QIMR Berghofer Medical Research Institute, Brisbane, QLD, Australia.
ORCID: 0000-0003-4626-7248

Matthew D Sacchet (MD)

Center for Depression, Anxiety, and Stress Research, McLean Hospital, Harvard Medical School, Belmont, MA, USA.

Philipp G Sämann (P)

Max Planck Institute of Psychiatry, Munich, Germany.

Anouk Schrantee (A)

Department of Radiology and Nuclear Medicine, location AMC, Amsterdam UMC, Amsterdam, The Netherlands.

Kang Sim (K)

West Region/Institute of Mental Health, Singapore, Singapore.
Yong Loo Lin School of Medicine/National University of Singapore, Singapore, Singapore.
ORCID: 0000-0003-3209-9626

Jair C Soares (JC)

Department of Psychiatry & Behavioral Sciences, The University of Texas Health Science Center at Houston, Houston, TX, USA.

Dan J Stein (DJ)

SA MRC Research Unit on Risk & Resilience in Mental Disorders, Department of Psychiatry & Neuroscience Institute, University of Cape Town, Cape Town, South Africa.
ORCID: 0000-0001-7218-7810

Leonardo Tozzi (L)

Department of Psychiatry & Behavioral Sciences, Stanford University, Stanford, CA, USA.
ORCID: 0000-0002-9429-6476

Nic J A van Der Wee (NJA)

Department of Psychiatry, Leiden University Medical Center, Leiden, The Netherlands.
Leiden Institute for Brain and Cognition, Leiden University Medical Center, Leiden, The Netherlands.

Marie-José van Tol (MJ)

Department of Biomedical Sciences of Cells and Systems, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.
ORCID: 0000-0002-9260-5490

Robert Vermeiren (R)

Curium-LUMC, Leiden University Medical Center, Leiden, The Netherlands.

Yolanda Vives-Gilabert (Y)

Instituto ITACA, Universitat Politècnica de València, Valencia, Spain.

Henrik Walter (H)

Division of Mind and Brain Research, Department of Psychiatry and Psychotherapy CCM, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin, Germany.
ORCID: 0000-0002-9403-6121

Martin Walter (M)

Department of Psychiatry and Psychotherapy, Jena, Germany.
Clinical Affective Neuroimaging Laboratory, Leibniz Institute for Neurobiology, Magdeburg, Germany.

Heather C Whalley (HC)

Centre for Clinical Brain Science, University of Edinburgh, Edinburgh, UK.
ORCID: 0000-0002-4505-8869

Katharina Wittfeld (K)

Department of Psychiatry and Psychotherapy, University Medicine Greifswald, Greifswald, Germany.
German Center for Neurodegenerative Diseases (DZNE), Site Rostock/Greifswald, Germany.
ORCID: 0000-0003-4383-5043

Sarah Whittle (S)

Melbourne Neuropsychiatry Centre, Department of Psychiatry, The University of Melbourne & Melbourne Health, Melbourne, VIC, Australia.

Margaret J Wright (MJ)

Queensland Brain Institute, The University of Queensland, Brisbane, QLD, Australia.
Centre for Advanced Imaging, The University of Queensland, Brisbane, QLD, Australia.
ORCID: 0000-0001-7133-4970

Tony T Yang (TT)

Department of Psychiatry & Weill Institute for Neurosciences, University of California, San Francisco, CA, USA.

Carlos Zarate (C)

Section on the Neurobiology and Treatment of Mood Disorders, National Institute of Mental Health, Bethesda, MD, USA.

Sophia I Thomopoulos (SI)

Imaging Genetics Center, Mark and Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine, University of Southern California, Marina del Rey, CA, USA.

Neda Jahanshad (N)

Imaging Genetics Center, Mark and Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine, University of Southern California, Marina del Rey, CA, USA.
ORCID: 0000-0003-4401-8950

Paul M Thompson (PM)

Imaging Genetics Center, Mark and Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine, University of Southern California, Marina del Rey, CA, USA.

Dick J Veltman (DJ)

Department of Psychiatry, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam Neuroscience, Amsterdam Public Health Research Institute, Amsterdam, The Netherlands.

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Recherchemedicale.com › Système nerveux › Système nerveux central › Encéphale › ENIGMA MDD: seven years of global neuroimaging...
Recherchemedicale.com › Comportement et mécanismes comportementaux › Émotions › Dépression › ENIGMA MDD: seven years of global neuroimaging...
Recherchemedicale.com › Troubles mentaux › Troubles de l'humeur › Trouble dépressif › Trouble dépressif majeur › ENIGMA MDD: seven years of global neuroimaging...
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Recherchemedicale.com › Sciences de l'information › Communication › Diffusion de l'information › ENIGMA MDD: seven years of global neuroimaging...
Recherchemedicale.com › Techniques d'investigation › Neuroimagerie › ENIGMA MDD: seven years of global neuroimaging...