Prevention of age-associated neuronal hyperexcitability with improved learning and attention upon knockout or antagonism of LPAR2.

Aging Animals Brain / metabolism Calcium-Binding Proteins / deficiency Chromatography, High Pressure Liquid Dentate Gyrus / metabolism Discriminant Analysis EGF Family of Proteins / deficiency Female Liver / metabolism Long-Term Potentiation Male Maze Learning / drug effects Memory / drug effects Mice Mice, Inbred C57BL Mice, Knockout Neurons / metabolism Principal Component Analysis Receptors, Lysophosphatidic Acid / antagonists & inhibitors Tandem Mass Spectrometry
Cognition Hippocampal excitability IntelliCage Long-term potentiation Lysophosphatidic acids Touchscreen

Journal

Cellular and molecular life sciences : CMLS
ISSN: 1420-9071
Titre abrégé: Cell Mol Life Sci
Pays: Switzerland
ID NLM: 9705402

Informations de publication

Date de publication:
Feb 2021
Historique:
received: 13 11 2019
accepted: 13 05 2020
revised: 16 04 2020
pubmed: 30 5 2020
medline: 2 3 2021
entrez: 30 5 2020
Statut: ppublish

Résumé

Recent studies suggest that synaptic lysophosphatidic acids (LPAs) augment glutamate-dependent cortical excitability and sensory information processing in mice and humans via presynaptic LPAR2 activation. Here, we studied the consequences of LPAR2 deletion or antagonism on various aspects of cognition using a set of behavioral and electrophysiological analyses. Hippocampal neuronal network activity was decreased in middle-aged LPAR2

Identifiants

DOI: 10.1007/s00018-020-03553-4 PMID: 32468095 PMC: PMC7897625
pubmed: 32468095
doi: 10.1007/s00018-020-03553-4
pii: 10.1007/s00018-020-03553-4
pmc: PMC7897625
doi:

Substances chimiques

Calcium-Binding Proteins 0
EGF Family of Proteins 0
Egfl7 protein, mouse 0
Receptors, Lysophosphatidic Acid 0

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

1029-1050

Subventions

Organisme : Deutsche Forschungsgemeinschaft
ID : CRC1039 A03
Organisme : Deutsche Forschungsgemeinschaft
ID : CRC1080 A03
Organisme : Deutsche Forschungsgemeinschaft
ID : CRC1080 B05
Organisme : Deutsche Forschungsgemeinschaft
ID : SFB1193 A05

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Auteurs

Caroline Fischer (C)

Institute of Clinical Pharmacology, Goethe-University Frankfurt, Faculty of Medicine, Frankfurt, Germany.

Heiko Endle (H)

Institute for Microscopic Anatomy and Neurobiology, University Medical Center of the Johannes Gutenberg University, Mainz, Germany.
Department of Neurology, University Medical Center of the Johannes Gutenberg University, Mainz, Germany.

Lana Schumann (L)

Institute of Clinical Pharmacology, Goethe-University Frankfurt, Faculty of Medicine, Frankfurt, Germany.

Annett Wilken-Schmitz (A)

Institute of Clinical Pharmacology, Goethe-University Frankfurt, Faculty of Medicine, Frankfurt, Germany.

Julia Kaiser (J)

Institute for Human Genetics, University Medical Center, Johannes Gutenberg University, Mainz, Germany.

Susanne Gerber (S)

Institute for Human Genetics, University Medical Center, Johannes Gutenberg University, Mainz, Germany.

Christina F Vogelaar (CF)

Department of Neurology, University Medical Center of the Johannes Gutenberg University, Mainz, Germany.

Mirko H H Schmidt (MHH)

Institute of Anatomy, Medical Faculty Carl Gustav Carus Technische Universität, School of Medicine, Dresden, Germany.

Robert Nitsch (R)

Institute for Translational Neuroscience, Westfälische Wilhelms Universität, Münster, Germany.

Isabel Snodgrass (I)

Institute of Clinical Pharmacology, Goethe-University Frankfurt, Faculty of Medicine, Frankfurt, Germany.

Dominique Thomas (D)

Institute of Clinical Pharmacology, Goethe-University Frankfurt, Faculty of Medicine, Frankfurt, Germany.

Johannes Vogt (J)

Center of Anatomy, University of Cologne, Cologne, Germany.

Irmgard Tegeder (I)

Institute of Clinical Pharmacology, Goethe-University Frankfurt, Faculty of Medicine, Frankfurt, Germany. itegeder@hotmail.com.
ORCID: 0000-0001-7524-8025

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Classifications MeSH

Recherchemedicale.com › Phénomènes physiologiques › Croissance et développement › Vieillissement › Prevention of age-associated neuronal...
Recherchemedicale.com › Eucaryotes › Animaux › Prevention of age-associated neuronal...
Recherchemedicale.com › Système nerveux › Système nerveux central › Encéphale › Prevention of age-associated neuronal...
Recherchemedicale.com › Acides aminés, peptides et protéines › Protéines › Protéines de transport › Protéines de liaison au calcium › Prevention of age-associated neuronal...
Recherchemedicale.com › Techniques d'investigation › Techniques de chimie analytique › Chromatographie › Chromatographie en phase liquide › Chromatographie en phase liquide à haute performance › Prevention of age-associated neuronal...
Recherchemedicale.com › Système nerveux › Système nerveux central › Encéphale › Prosencéphale › Télencéphale › Cerveau › Cortex cérébral › Hippocampe › Gyrus denté › Prevention of age-associated neuronal...
Recherchemedicale.com › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Statistiques comme sujet › Analyse discriminante › Prevention of age-associated neuronal...
Recherchemedicale.com › Facteurs biologiques › Protéines et peptides de signalisation intercellulaire › Protéines de la famille de l'EGF › Prevention of age-associated neuronal...
Recherchemedicale.com › Système digestif › Foie › Prevention of age-associated neuronal...
Recherchemedicale.com › Phénomènes physiologiques de l'appareil locomoteur et du système nerveux › Phénomènes physiologiques du système nerveux › Plasticité neuronale › Potentialisation à long terme › Prevention of age-associated neuronal...
Recherchemedicale.com › Phénomènes psychologiques › Processus mentaux › Apprentissage du labyrinthe › Prevention of age-associated neuronal...
Recherchemedicale.com › Phénomènes psychologiques › Processus mentaux › Mémoire › Prevention of age-associated neuronal...
Recherchemedicale.com › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Prevention of age-associated neuronal...
Recherchemedicale.com › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Lignées consanguines de souris › Souris de lignée C57BL › Prevention of age-associated neuronal...
Recherchemedicale.com › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Souris transgéniques › Souris knockout › Prevention of age-associated neuronal...
Recherchemedicale.com › Cellules › Neurones › Prevention of age-associated neuronal...
Recherchemedicale.com › Techniques d'investigation › Analyse en composantes principales › Prevention of age-associated neuronal...
Recherchemedicale.com › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Récepteurs de surface cellulaire › Récepteurs couplés aux protéines G › Récepteurs aux lysophospholipides › Récepteurs à l'acide phosphatidique › Prevention of age-associated neuronal...
Recherchemedicale.com › Techniques d'investigation › Techniques de chimie analytique › Spectrométrie de masse › Spectrométrie de masse en tandem › Prevention of age-associated neuronal...