Fractional iron absorption from enteric-coated ferrous sulphate tablet.
Anaemia
enteric-coated tablets
ferrous sulphate
iron deficiency
iron deficiency anaemia
iron supplementation
Journal
The Indian journal of medical research
ISSN: 0971-5916
Titre abrégé: Indian J Med Res
Pays: India
ID NLM: 0374701
Informations de publication
Date de publication:
04 2020
04 2020
Historique:
entrez:
29
5
2020
pubmed:
29
5
2020
medline:
4
3
2021
Statut:
ppublish
Résumé
Iron supplementation is widely used public health measure to manage iron deficiency anaemia. In India, enteric-coated iron tablets are administered to adolescent boys and girls to avoid adverse effects such as gastritis, which reduces compliance, but this may result in poor iron absorption. Data on the absorption of iron from enteric-coated ferrous sulphate tablets are lacking. The present study using stable isotopic approach was aimed to measure iron absorption in iron deficient women. Iron absorption was measured from stable isotope-labelled enteric-coated ferrous sulphate ( Eight women completed the iron absorption study. Iron absorption was found to be significantly lower in ECFS compared to UCFS (3.5 vs. 12%, P <0.05) consumption. Our study showed poor iron bioavailability from ECFS, and supplementation programmes may consider UCFS tablets for better haematological outcomes.
Sections du résumé
Background & objectives
Iron supplementation is widely used public health measure to manage iron deficiency anaemia. In India, enteric-coated iron tablets are administered to adolescent boys and girls to avoid adverse effects such as gastritis, which reduces compliance, but this may result in poor iron absorption. Data on the absorption of iron from enteric-coated ferrous sulphate tablets are lacking. The present study using stable isotopic approach was aimed to measure iron absorption in iron deficient women.
Methods
Iron absorption was measured from stable isotope-labelled enteric-coated ferrous sulphate (
Results
Eight women completed the iron absorption study. Iron absorption was found to be significantly lower in ECFS compared to UCFS (3.5 vs. 12%, P <0.05) consumption.
Interpretation & conclusions
Our study showed poor iron bioavailability from ECFS, and supplementation programmes may consider UCFS tablets for better haematological outcomes.
Identifiants
pubmed: 32461401
pii: IndianJMedRes_2020_151_4_371_284207
doi: 10.4103/ijmr.IJMR_1464_18
pmc: PMC7371052
doi:
Substances chimiques
Ferrous Compounds
0
Tablets
0
ferrous sulfate
39R4TAN1VT
Iron
E1UOL152H7
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
371-374Subventions
Organisme : Wellcome Trust
Pays : United Kingdom
Déclaration de conflit d'intérêts
None
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