Confounding and effect measure modification in reproductive medicine research.
Journal
Human reproduction (Oxford, England)
ISSN: 1460-2350
Titre abrégé: Hum Reprod
Pays: England
ID NLM: 8701199
Informations de publication
Date de publication:
01 05 2020
01 05 2020
Historique:
received:
18
12
2019
revised:
17
02
2020
pubmed:
20
5
2020
medline:
28
4
2021
entrez:
20
5
2020
Statut:
ppublish
Résumé
The majority of research within reproductive and gynecologic health, or investigating ART, is observational in design. One of the most critical challenges for observational studies is confounding, while one of the most important for discovery and inference is effect modification. In this commentary, we explain what confounding and effect modification are and why they matter. We present examples illustrating how failing to adjust for a confounder leads to invalid conclusions, as well as examples where adjusting for a factor that is not a confounder also leads to invalid or imprecise conclusions. Careful consideration of which factors may act as confounders or modifiers of the association of interest is critical to conducting sound research, particularly with complex observational studies in reproductive medicine.
Identifiants
pubmed: 32424412
pii: 5839890
doi: 10.1093/humrep/deaa051
pmc: PMC8453425
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
1013-1018Subventions
Organisme : NICHD NIH HHS
ID : L50 HD085412
Pays : United States
Informations de copyright
© The Author(s) 2020. Published by Oxford University Press on behalf of the European Society of Human Reproduction and Embryology. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.
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