Pleiotropy complicates a trade-off between phage resistance and antibiotic resistance.
Anti-Bacterial Agents
/ pharmacology
Bacterial Outer Membrane Proteins
/ genetics
Coliphages
/ physiology
Drug Resistance, Bacterial
/ physiology
Escherichia coli
/ drug effects
Escherichia coli Proteins
/ genetics
Gene Library
Genes, Bacterial
Genetic Pleiotropy
Host Specificity
Lipopolysaccharides
/ genetics
Membrane Transport Proteins
/ genetics
Mutation
Escherichia coli
bacteriophage
efflux pump
trade-off
virus
Journal
Proceedings of the National Academy of Sciences of the United States of America
ISSN: 1091-6490
Titre abrégé: Proc Natl Acad Sci U S A
Pays: United States
ID NLM: 7505876
Informations de publication
Date de publication:
26 05 2020
26 05 2020
Historique:
pubmed:
20
5
2020
medline:
25
8
2020
entrez:
20
5
2020
Statut:
ppublish
Résumé
Bacteria frequently encounter selection by both antibiotics and lytic bacteriophages. However, the evolutionary interactions between antibiotics and phages remain unclear, in particular, whether and when phages can drive evolutionary trade-offs with antibiotic resistance. Here, we describe
Identifiants
pubmed: 32424102
pii: 1919888117
doi: 10.1073/pnas.1919888117
pmc: PMC7260982
doi:
Substances chimiques
Anti-Bacterial Agents
0
Bacterial Outer Membrane Proteins
0
Escherichia coli Proteins
0
Lipopolysaccharides
0
Membrane Transport Proteins
0
tolC protein, E coli
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.
Langues
eng
Sous-ensembles de citation
IM
Pagination
11207-11216Subventions
Organisme : NCATS NIH HHS
ID : UL1 TR001863
Pays : United States
Organisme : Howard Hughes Medical Institute
Pays : United States
Organisme : NIAID NIH HHS
ID : R21 AI144345
Pays : United States
Informations de copyright
Copyright © 2020 the Author(s). Published by PNAS.
Déclaration de conflit d'intérêts
Competing interest statement: P.E.T. discloses a financial interest in Felix Biotechnology Inc., a company that seeks to commercially develop phages for use as therapeutics, with certain rights to license any patents resulting from this work. A.R.B., B.K.C., and P.E.T. disclose a provisional patent application involving phage therapy.
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